financially supported by the National Natural Science Foundation of China (Nos. 22001034 and 21804019);the Open Fund of the Jiangxi Province Key Laboratory of Synthetic Chemistry (No. JXSC202008);the Research Found of East China University of Technology (Nos. DHBK2019264, DHBK2019265 and DHBK2019267)。
A simple and efficient method for the synthesis of pyrazoles through a silicotungstic acid (H_(4)SiW_(12)O_(40))-catalyzed cyclization of epoxides/aldehydes and sulfonyl hydrazides has been developed. Various epoxides...
We gratefully acknowledge the National Natural Science Foundation of China(Nos.21801040,22008028,22102022);the Natural Science Foundation of Jiangxi Province(Nos.20192BAB213006,20181BBH80007);the Opening Project of Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices(Nos.PMND202001,PMND202003);East China University of Technology Research Foundation for Advanced Talents(No.DHBK2017168)provides financial support.
An efficient palladium-catalyzed sulfonylative coupling for the synthesis of benzyl(allyl)sulfones from sulfonyl hydrazides and carbonates was developed.The novel methodology employs easily accessible chemical feedsto...
The authors are grateful for financial support from the Beijing Natural Science Foundation(No.JQ18024);the National Natural Science Foundation of China(Nos.21822701,91953111,21672012);the Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910001001);State Key Laboratory of Natural and Biomimetic Drugs.
An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prep...
Financial support for this work was gratefully received from the National Natural Science Foundation of China(Nos.22077080,21907064 and 91753102);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ14).
Main observation and conclusion Selenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans-thio/selenoesterification reaction.However,existin...
Fund of Luzhou Government and Southwest Medical University(Nos.2019LZXNYDJ28,2018LZXNYD-ZK33,2018LZXNYD-ZK39);the Open Project of Central Nervous System Drug Key Laboratory of Sichuan Province(No.200023-01SZ);the research fund of Southwest Medical University(Nos.2017-ZRZD-020 and 2017-ZRQN-031).
Main observation and conclusion Alkoxy radical-mediated carbon-carbon bond cleavages have emerged as a powerful strategy to complement traditional ionic-type transformations.However,carbon-carbon cleavage reaction tri...
the FAPESP(Fundacao de Amparo a Pesquisa de Sao Paulo)(2017/11764-2)。
New lanthanide(Eu3+ and Gd3+) complexes were successfully synthesized and the effect of the p-phe nyl substituent on the Eu3+luminescent properties was evaluated.In this sense,benzhydrazide,p-toluic hydrazide,4-hydrox...
A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been devel- oped. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino...
An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed o...
A novel and efficient approach to sulfonamides has been developed. Using TBHP as the oxidant and NH4I (20 mol%) as the catalyst, arylsulfonyl hydrazides reacted with amines to provide sulfonamides in moderate to goo...
National Basic Research Program of China (973 program, 2013CB932800);the National Natural Science Foundation of China (NSFC, 31100524 to M.Z., 31170817 for C.T., and 20972148 to L.L.)
The C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin (Ub-AMC) is an important probe for fluorescencebased analysis of deubiquitinating enzyme (DUB) activity. It is important to develop more efficien...