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作品数：63被引量：318H指数：10
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相关领域：医药卫生更多>>
相关作者：陈敬玉王成黄河更多>>
相关机构：中山大学浙江理工大学淡江大学浙江大学医学院附属第一医院更多>>
相关期刊：《Signal Transduction and Targeted Therapy》《Neuroimmunology and Neuroinflammation》《Precision Clinical Medicine》《Asian Journal of Andrology》更多>>
相关基金：国家自然科学基金安徽省自然科学基金中国博士后科学基金湖北省自然科学基金更多>>
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基于AIGC技术的民族服饰设计研究——以畲族为例被引量：1
《丝绸》2025年第1期20-29,共10页吴海鸣 陈敬玉 
浙江省哲学社会科学年度课题项目(22NDJC077YB);浙江省大学生科技创新活动计划(新苗人才计划)项目(2024R406B073)。
民族服饰的当代创新需要在创作过程中寻求民族传统与现代审美的最佳平衡点,生成式人工智能(AIGC)技术的出现为民族服饰的当代设计应用提供了新的路径和方法。文章通过分析目前人工智能技术在民族服饰生成过程中遇到的问题,提出基于专属...
关键词：AIGC 民族服饰 辅助设计 畲族 Stable Diffusion Low-Rank Adaptation CHECKPOINTS 
Cytokine release syndrome induced by anti-programmed death-1 treatment in a psoriasis patient:A dark side of immune checkpoint inhibitors
《World Journal of Clinical Cases》2024年第35期6782-6790,共9页JoséLuis Maldonado-García Ana Fragozo Lenin Pavón 
Supported by Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz,No.NC23189.0.
In recent years,cancer immunotherapy has introduced novel treatments,such as monoclonal antibodies,which have facilitated targeted therapies against tumor cells.Programmed death-1(PD-1)is an immune checkpoint expresse...
关键词：Immune checkpoints inhibitors Programmed death-1 Cancer immunotherapy PSORIASIS Cytokine release syndrome Immune-related adverse events 
Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4+T cells
《Cellular & Molecular Immunology》2024年第11期1296-1308,共13页Shuai Wang Lijun Meng Nan Xu Huan Chen Zhaofeng Xiao Di Lu Xiaohui Fan Limin Xia Jun Chen Shusen Zheng Qiang Wei Xuyong Wei Xiao Xu 
supported by the Key Program,National Natural Science Foundation of China(No.81930016);National Key Research and Development Program of China(No.2021YFA1100500);Key Research&Development Plan of Zhejiang Province(No.2019C03050);Construction Fund of Key Medical Disciplines of Hangzhou(OO20200093);Key Research&Development Plan of Zhejiang Province(No.2021C03118),Projects of Medical and Health Technology Program in Zhejiang Province(WKJ-ZJ-2120);National Natural Science Foundation of China(No.82273177,No.12304256);Natural Science Foundation of Zhejiang Province(LY22H160046,LQ24C050005);Key Research and Development Plan of Zhejiang Province(2022C03108).Joint Funds of the National Natural Science Foundation of China(No.U23A20451).
Hepatocellular carcinoma(HCC)is a highly malignant tumor with significant global health implications.The role of CD4+T cells,particularly conventional CD4+T cells(Tconvs),in HCC progression remains unexplored.Furtherm...
关键词：MATR3 Tconv ARID1A TOX EXHAUSTION 
Intracellular checkpoints for NK cell cancer immunotherapy
《Frontiers of Medicine》2024年第5期763-777,共15页Yingying Huang Zhigang Tian Jiacheng Bi 
supported by the National Key R&D Program of China(No.2020YFA0710802 to Jiacheng Bi);Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110174 to Yingying Huang);the National Natural Science Foundation of China(No.82071768 to Jiacheng Bi).
Natural killer(NK)cells are key innate immune lymphocytes,which play important roles against tumors.However,tumor-infiltrating NK cells are always hypofunctional/exhaustive.On the one hand,this state is contributed by...
关键词：genomic editing NK cell exhaustion immune checkpoint inhibitory molecules immune tolerance 
Common endocrine system adverse events associated with immune checkpoint inhibitors
《Cancer Pathogenesis and Therapy》2024年第3期164-172,共9页Ying Li Junfeng Zhao Yue Wang Yali Xu Ruyue Li Ying Zhao Xue Dong Xiujing Yao Yintao Li 
supported by the National Natural Science Foundation of China(No.82373044);the Natural Science Foundation of Shandong Province(No.ZR2022LSW001).
Immune checkpoint inhibitors(ICIs),a novel anti-tumor therapeutic modality,are monoclonal antibodies targeting certain immune checkpoints(ICs)that reactivate T cells to achieve anti-tumor immunity by targeting,binding...
关键词：Immune checkpoint inhibitors Immune checkpoints Cytotoxic T-lymphocyte antigen 4 Programmed cell death-1 Programmed cell death-ligand 1 Endocrine autoimmune-related adverse reactions 
Energy-Efficient Driving Strategy for High-Speed Trains with Considering the Checkpoints
《Chinese Journal of Electronics》2024年第3期847-858,共12页Zixuan ZHANG Yuan CAO Shuai SU 
supported by the National Natural Science Foundation of China (Grant Nos.U22A2046,52172322,and U1934219);the Science and Technology Research Development Plan of China Railway Corporation (Grant Nos.L2021G003 and L2022G010);the State Key Laboratory of Rail Traffic Control and Safety (Grant No.RCS2022ZZ003);the Fundamental Research Funds for the Central Universities (Grant No.2022JBQY001);the National Science Fund for Excellent Young Scholars (Grant No.52022010)。
With rising energy prices and concerns about environmental issues,energy-efficient driving strategies(EEDS)for high-speed trains have received a substantial amount of attention.In particular,energy-saving schemes play...
关键词：ENERGY-EFFICIENCY High-speed trains CHECKPOINTS 
Development of small molecule drugs targeting immune checkpoints被引量：1
《Cancer Biology & Medicine》2024年第5期382-399,共18页Luoyi Chen Xinchen Zhao Xiaowei Liu Yujie Ouyang Chuan Xu Ying Shi 
supported by the National Natural Science Foundation of China(Grant Nos.82203539 and 92259102);Provincial Cooperation Project of Science and Technology Department of Sichuan Province(Grant No.2023YFSY0043);the National Key Research and Development Program of China(Grant No.2023YFC3402100).
Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune chec...
关键词：Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα 
Pembrolizumab autoimmune related diabetes:Moving forward,keep learning
《World Journal of Clinical Oncology》2024年第5期576-579,共4页Jose Angel Garcia Diego Alcaraz Esther Holgado Felipe Couñago 
Immune checkpoint inhibitors(and more specifically programmed cell death 1/programmed cell death ligand 1 inhibitors as Pembrolizumab)initiated a revolution in the field of melanoma and have now expanded to several tu...
关键词：Immune checkpoints Pembrolizumab IMMUNOTHERAPY Side effects Endocrine system Diabetes mellitus 
Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models被引量：1
《Chinese Journal of Integrative Medicine》2024年第4期348-358,共11页FU Yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han LIAO Kun-yu CHEN Ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien 
Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma model.M...
关键词：Pien Tze Huang METASTASIS anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine 
Small-molecule agents for cancer immunotherapy被引量：3
《Acta Pharmaceutica Sinica B》2024年第3期905-952,共48页Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu 
supported by the National Natural Science Foundation of China(Nos.U21A20421,82073882,82073317,81772540 and 82272996);the Key Project of Science Technology Program of Guangzhou(No.2023B03J0029,China);the National Key R&D Program of China(No.2022YFE0209700);the Science and Technology Program of Guangzhou(Nos.202201010819 and 202206010081,China)。
Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regress...
关键词：Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment 
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