ORGANOTYPIC

作品数：20被引量：13H指数：2
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相关领域：医药卫生更多>>
相关作者：丁晔李良更多>>
相关机构：首都医科大学更多>>
相关期刊：《World Journal of Gastroenterology》《Journal of Pharmacy and Pharmacology》《International Journal of Extreme Manufacturing》《Biomedical Engineering Frontiers》更多>>
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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development
《Neural Regeneration Research》2025年第3期900-912,共13页Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang 
supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC);the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ);the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ);Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...
关键词：bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells 
Engineering vascularized organotypic tissues via module assembly
《International Journal of Extreme Manufacturing》2024年第1期155-175,共21页Zhenzhen Zhou Changru Liu Yuting Guo Yuan Pang Wei Sun 
Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular mat...
关键词：vascularized organotypic tissue module assembly regenerative medicine tissue engineering 
BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development被引量：1
《Neural Regeneration Research》2024年第2期447-457,共11页Michael W.Weible II Michael D.Lovelace Hamish D.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling 
supported by grants from the National Health and Medical Research Council(NHMRC)of Australia(Nos.571100 and 1048082);the Baxter Charitable Foundation(to TCL);Medical Research grants from the Rebecca L.Cooper Medical Research Foundation(to MWW,TCL,and MDL);supported by a Charles D.Kelman,M.D.Postdoctoral Award(2010)from the International Retinal Research Foundation(USA)。
Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not...
关键词：BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor NEUROSPHERE ORGANOTYPIC reaggregate sensory columns 
Organotypic Models for Functional Drug Testing of Human Cancers
《Biomedical Engineering Frontiers》2023年第1期103-112,共10页Yu Ling Huang Lindsay K.Dickerson Heidi Kenerson Xiuyun Jiang Venu Pillarisetty Qiang Tian Leroy Hood Taranjit S.Gujral Raymond S.Yeung 
This research was funded by the Department of Defense(DOD-AMRAA/W81XWH-19-1-0546 to V.P.,T.S.G.,and R.S.Y.);National Institutes of Health(R01 CA181445 to V.P.and T.S.G.);the Fibrolamellar Cancer Foundation(T.S.G.);the American Cancer Society(RSG-19-197-01-CDD to T.S.G.);the Climb to Fight Cancer Fellowship(Y.L.H.).L.K.D.is the recipient of a Cancer Research Institute/Fibrolamellar Cancer Foundation Postdoctoral Fellowship(CRI Award#4093).
In the era of personalized oncology,there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers.An ideal assay will serve as a diagnostic companion to ...
关键词：CANCER HORIZON HUMAN 
A benchtop brain injury model using resected donor tissue from patients with Chiari malformation
《Neural Regeneration Research》2023年第5期1057-1061,共5页Jacqueline A.Tickle Jon Sen Christopher Adams David N.Furness Rupert Price Viswapathi Kandula Nikolaos Tzerakis Divya M.Chari 
funded by a grant from the North Staffordshire Medical Institute,UK (to DMC and NT)。
The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability ...
关键词：biomaterial Chiari malformation cerebellar slice human tissue injury model NEUROREGENERATION ORGANOTYPIC traumatic brain injury 
Transplanted choroidal plexus epithelial cells can integrate with organotypic spinal cord slices into a new system
《BIOCELL》2022年第6期1537-1544,共8页JINGJIE LIU XIAOYAN DING LI XIANG SHENGLI HUANG 
This study was supported by National Natural Science Foundation of China(81471247).
This study aimed to evaluate the integration of transplanted choroidal plexus epithelial cells with organotypic spinal cord slices.Organotypic spinal cord slices,normally cultured for 6 days,were divided into control ...
关键词：Cell transplantation Choroidal plexus epithelial cells Integration Organotypic spinal cord slices 
Organotypic hippocampal slices,an emerging tool to model synucleinopathies
《Neural Regeneration Research》2021年第5期999-1000,共2页Sara Elfarrash Poul Henning Jensen 
Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s disease.PD has been traditionally considered a motoric disorder characterized by tremor,rigidity and bradykinesia,however ...
关键词：ALZHEIMER IMPAIRMENT settled 
Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds被引量：2
《Neuroscience Bulletin》2019年第2期244-252,共9页Xin-Rui Qi Ronald W.H.Verwer Ai-Min Bao Rawien A.Balesar Sabina Luchetti Jiang-Ning Zhou Dick F.Swaab 
supported by the National Natural Science Foundation of China (81501172);the China Exchange Programme of the Royal Netherlands Academy of Arts and Sciences (10CDP0037 and 05CD9027);the Shanghai Municipal Commission of Health and Family Planning (20154Y0016);an Innovation Project of the Chinese Academy of Sciences (KSCX2-SW-217);a National Basic Research Development Program of China (2006CB500705);the Internationale Stichting Alzheimer Onderzoek (05501)
Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary...
关键词：Alzheimer’s disease BRAIN bank Brain-derived neurotrophic factor Depression Electrical activity HUMAN BRAIN slice CULTURE NEUROPSYCHIATRIC disorders ORGANOTYPIC CULTURE Postmortem HUMAN BRAIN TISSUE Resected HUMAN BRAIN TISSUE 
Seeing the wood for the trees:towards improved quantification of glial cells in central nervous system tissue被引量：1
《Neural Regeneration Research》2018年第9期1520-1523,共4页Sinéad Healy Jill McMahon Una FitzGerald 
supported by a grant from Thomas Crawford Hayes Research Fund;the NUI Galway College of Science scholarship to SH;a grant from NUI Galway Foundation Office to JM
The following mini-review attempts to guide researchers in the quantification of fluorescently-labelled proteins within cultured thick or chromogenically-stained proteins within thin sections of brain tissue.It follow...
关键词：organotypic brain slice culture glial cell quantification thresholding algorithms Fiji Image J Bio Voxxel plug-in STEREOLOGY 
Regenerative Properties of Fetal n. Raphe Cells in Modeling Injuries of Serotonergic Neurite-Glial Fibers in Vitro
《Journal of Pharmacy and Pharmacology》2017年第8期515-520,共6页Vasylyeva I. G. Oleksenko N. P. Chopyk N. G. Galanta O. S. Shuba I. M., Tsyubko O. I. Snitsar N. D. 
It is considered that renewal of growth in serotoninergic caudal fibers their sprouting to injury site and formation ofoutgrowth net is factor for locomotion recovery. The aim of our work was to study the influence of...
关键词：FETAL rat nerve cells  serotonin  n. raphe  ORGANOTYPIC culture  suspension culture. 
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