NEUROSPHERE

作品数：12被引量：27H指数：4
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相关领域：医药卫生更多>>
相关机构：第三军医大学西南医院更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Translational Medicine》《Journal of Biomedical Research》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development被引量：1
《Neural Regeneration Research》2024年第2期447-457,共11页Michael W.Weible II Michael D.Lovelace Hamish D.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling 
supported by grants from the National Health and Medical Research Council(NHMRC)of Australia(Nos.571100 and 1048082);the Baxter Charitable Foundation(to TCL);Medical Research grants from the Rebecca L.Cooper Medical Research Foundation(to MWW,TCL,and MDL);supported by a Charles D.Kelman,M.D.Postdoctoral Award(2010)from the International Retinal Research Foundation(USA)。
Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not...
关键词：BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor NEUROSPHERE ORGANOTYPIC reaggregate sensory columns 
Essential tremor:A three-dimensional neurosphere in vitro model to assess the neurotoxicity of harmane
《Journal of Traditional Chinese Medical Sciences》2023年第1期19-34,共16页Rania Aro Amandine Nachtergael Laurence Ris Mario Manto Pierre Duez 
funded through a Fonds Medical pour la Recherche dans le Hainaut(FMRH)grant;a Kangaroo grant from the UMONS Health Institute.
Objectives: To use a novel in vitro model of three-dimensional(3D) neurosphere cultures to assess neurotoxic or neuroprotective effects with harmane as a model compound.Methods: A reproducible model of 3D spheroids wa...
关键词：3D spheroid TOXICITY NEUROTOXICITY HARMANE Essential tremor 
Valproic acid enhances neurosphere formation in cultured rat embryonic cortical cells through TGFβ1 signaling被引量：1
《The Journal of Biomedical Research》2022年第2期127-140,共14页Cui Qi Jiaqi Zhang Yuanyuan Wang Mingyan Lin Jun Gao Haiying Lu 
This work was supported by grants from the Key R&D Program of Jiangsu Province(Grant No.2017CX010);the National Natural Science Foundation of China(Grant No.81973308)to J.G.;the Nanjing Science and Technology Development Program(Grant No.201402021)to H.L.
This study aimed to investigate the effect and mechanism of valproic acid(VPA)on the neurosphere formation in rat embryonic cortical cells.We used free-floating neurosphere formation as a model system to evaluate the ...
关键词：valproic acid neural stem cells neurosphere formation PROLIFERATION transforming growth factorβ1 
The neurosphere assay:an effective in vitro technique to study neural stem cells被引量：1
《Neural Regeneration Research》2021年第11期2229-2231,共3页Rita Soares Filipa F.Ribeiro Diogo M.Lourenço Rui S.Rodrigues João B.Moreira Ana M.Sebastião Vanessa A.Morais Sara Xapelli 
supported by IF/01227/2015 and UID/BIM/50005/2019,projeto financiado pela Fundação para a Ciência e a Tecnologia(FCT)/Ministério da Ciência,Tecnologia e Ensino Superior(MCTES)através de Fundos do Orçamento de Estado.RS(SFRH/BD/128280/2017),FFR(IMM/CT/35-2018),DML(PD/BD/141784/2018);RSR(SFRH/BD/129710/2017)received a fellowship from FCT.
Neural stem cells(NSCs)are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal,astroglial,and oligodendroglial lineages,in defined processes termed neurogenesis,a...
关键词：walls NEURAL BECOMING 
Sphere-forming corneal cells repopulate dystrophic keratoconic stroma:Implications for potential therapy被引量：2
《World Journal of Stem Cells》2020年第1期35-54,共20页Himanshu Wadhwa Salim Ismail Jennifer J McGhee Bert Van der Werf Trevor Sherwin 
Supported by Save Sight Society of New Zealand,No.37116543;New Zealand Wound Care Society,No.3713325;John Hamel MacGregor Trust
BACKGROUND Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision loss.Cells extracted from peripheral corneas can form stem cell-enriched s...
关键词：KERATOCONUS Cell culture IMMUNOHISTOCHEMISTRY Quantitative PCR Digital PCR SPHEROID Holoclone NEUROSPHERE Regeneration 
Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells被引量：4
《Protein & Cell》2016年第9期624-637,共14页Jing-Peng Fu Wei-Chuan Mo Ying Liu Perry F. Bartlett Rong-Qiao He 
Living organisms are exposed to the geomagnetic field （GMF） throughout their lifespan. Elimination of the GMF, resulting in a hypogeomagnetic field （HMF）, leads to central nervous system dysfunction and abnormal d...
关键词：hypomagnetic field neural progenitor/stemcells NEUROSPHERE PROLIFERATION STERNNESS MULTIPOTENCY 
Nerve growth factor promotes in vitro proliferation of neural stem cells from tree shrews被引量：4
《Neural Regeneration Research》2016年第4期591-596,共6页Liu-lin Xiong Zhi-wei Chen Ting-hua Wang 
supported by a grant from the National Key Technology Research and Development Program of the Ministry of Science and Technology of China,No.2014BAI01B00
Neural stem cells promote neuronal regeneration and repair of brain tissue after injury,but have limited resources and proliferative ability in vivo.We hypothesized that nerve growth factor would promote in vitro prol...
关键词：nerve regeneration tree shrews hippocampus neural stem cells cell proliferation nerve growth factor neurosphere embryo cell number cell therapy in vitro neural regeneration 
Role of nestin in glioma invasion被引量：1
《World Journal of Translational Medicine》2015年第3期78-87,共10页Alex Lin Luigi Marchionni Jeffrey Sosnowski David Berman Charles G Eberhart Eli E Bar 
Supported by Brain Tumor Funders Collaborative
AIM: To determine the role for the intermediate filament protein nestin in glioma invasion. METHODS: We examined the expression and function of nestin in gliomas(Grades Ⅱ-Ⅳ as defined by the World Health Organizatio...
关键词：NESTIN STEM cells MIGRATION GLIOMA NEUROSPHERE 
Growth and differentiation of neural stem cells in a three-dimensional collagen gel scaffold被引量：5
《Neural Regeneration Research》2013年第4期313-319,共7页Fei Huang Qiang Shen Jitong Zhao 
Collagen protein is an ideal scaffold material for the transplantation of neural stem cells. In this study rat neural stern cells were seeded into a three-dimensional collagen gel scaffold, with suspension cultured ne...
关键词：neural regeneration stem cells neural stem cells collagen gel SCAFFOLD central nervous system proliferation DIFFERENTIATION NEUROSPHERE photographs-containing paper NEUROREGENERATION 
Comparative study on the stem cell phenotypes of C6 cells under different culture conditions被引量：3
《Chinese Medical Journal》2011年第19期3118-3126,共9页ZHANG Suo-jun YE Fei XIE Rui-fan HU Feng WANG Bao-feng WAN Feng GUO Dong-sheng LEI Ting 
This work is supported by grants from the National Natural Science Foundation of China （No. 30801177, No. 30901749, and No. 81001116）.
Background Glioma stem cell （GSC） hypothesis posits that a subpopulation of cells within gliomas have true clonogenic and tumorigenic potential. Significantly, a more controversial correlate to GSC is that cells in ...
关键词：C6 glioma stem cell NEUROSPHERE CD133 side population LAMININ 
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