云南高校图书馆联盟文献共享服务平台- FIBROGENESIS

FIBROGENESIS: 作品数：46被引量：605H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陈志南边惠洁李浩吴佼更多>>; 相关机构：第四军医大学同济大学上海中医药大学更多>>; 相关期刊：《Journal of Bio-X Research》《World Journal of Gastroenterology》《肝脏》《Current Medical Science》更多>>; 相关基金：国家自然科学基金河北省自然科学基金上海市教育委员会重点学科基金广西壮族自治区自然科学基金更多>>

TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway: 《Current Medical Science》2024年第3期519-528,共10页Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG; supported by grants from the National Natural Science Foundation of China(No.82270545 and No.81870381);Natural Science Foundation of Hebei Province(No.H2014206446)。; Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium ...; 关键词：tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease MYOFIBROBLASTS transforming growth factor-β1

Gut microbiota controls the development of chronic pancreatitis:A critical role of short-chain fatty acids-producing Gram-positive bacteria被引量：7: 《Acta Pharmaceutica Sinica B》2023年第10期4202-4216,共15页Li-Long Pan Zheng-Nan Ren Jun Yang Bin-Bin Li Yi-Wen Huang Dong-Xiao Song Xuan Li Jia-Jia Xu Madhav Bhatia Duo-Wu Zou Chun-Hua Zhou Jia Sun; supported by funds from the National Natural Science Foundation of China(Grant Nos.82070666,82122068);the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province(Grant No.BK20200026,China);the Collaborative Innovation Center of Food Safety and Quality Control of Jiangsu Province,the Fundamental Research Funds for the Central Universities(Grant Nos.JUSRP221037,JUSRP22007,China);the China Postdoctoral Science Foundation(Grant No.2022M721366);the Excellent Postdoctoral Program of Jiangsu Province(Grant No.2023ZB168,China);Wuxi City’s first“double hundred”young and middle-aged medical and health talents(Grant No:BJ2020045,China);Wuxi Social Development Science and Technology Demonstration Project(Grant No:N20201003,China)。; Chronic pancreatitis(CP)is a progressive and irreversible fibroinflammatory disorder,accompanied by pancreatic exocrine insufficiency and dysregulated gut microbiota.Recently,accumulating evidence has supported a corr...; 关键词：Chronic pancreatitis Antibiotic exposure Gut microbiota Short-chain fatty acids-producing bacteria Pancreatic fibrogenesis Macrophage responses Toll-like receptor 4

Potential biomarkers for diagnosis and disease evaluation of idiopathic pulmonary fibrosis被引量：2: 《Chinese Medical Journal》2023年第11期1278-1290,共13页Qing Wang Zhaoliang Xie Nansheng Wan Lei Yang Zhixian Jin Fang Jin Zhaoming Huang Min Chen Huiming Wang Jing Feng; National Natural Science Foundation of China(Nos.81970083 and 82170097); Idiopathic pulmonary fibrosis(IPF)is a chronic progressive lung disease characterized by progressive lung fibrogenesis and histological features of usual interstitial pneumonia.IPF has a poor prognosis and presents a ...; 关键词：Alveolar epithelial cell dysfunction BIOMARKER DIAGNOSIS FIBROGENESIS Extracellular matrix remodeling Idiopathic pulmonary fibrosis Immune dysfunction

Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma被引量：5: 《World Journal of Gastroenterology》2022年第36期5250-5264,共15页Aswathy R Devan Keechilat Pavithran Bhagyalakshmi Nair Maneesha Murali Lekshmi R Nath; Supported by the Amrita Vishwa Vidyapeetham SEED grant (K-PHAR-22-662); Transforming growth factor-beta(TGF-β)is a multifunctional cytokine that performs a dual role as a tumor suppressor and tumor promoter during cancer progression.Among different ligands of the TGF-βfamily,TGF-β1 mod...; 关键词：Transforming growth factor-beta 1 Inflammation IMMUNOSUPPRESSION FIBROGENESIS Hepatocellular carcinoma Biomarker IMMUNOTHERAPY

Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients被引量：4: 《World Journal of Hepatology》2021年第2期218-232,共15页Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes; the National Council for Science and Technology,No.SALUD-2016-272579 and No.PAPIIT-UNAM TA200515.; BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few s...; 关键词：Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C FIBROGENESIS Fibrolysis

Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis被引量：1: 《Journal of Bio-X Research》2019年第1期16-24,共9页Zhipeng Liu Naga Chalasani Jingmei Lin Samer Gawrieh Yuan He Yan J.Tseng Wanqing Liu; supported in part by a NIH grant,No.R01 DK106540(to WL).; The genetic basis underlying liver fibrosis remains largely unknown.We conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level i...; 关键词：hepatic fibrosis GENOMICS macrophage migration inhibitory factor alpha-smooth muscle actin pathway enrichment analysis genetic susceptibility

Fibrogenesis in inflammatory bowel disease——A bright road ahead: 《中华炎性肠病杂志（中英文）》2018年第1期3-4,共2页Florian Rieder Claudio Fiocchi; Intestinal fibrosis is a frequent complication of inflammatory bowel diseases (IBD),and can lead to stricture formation and intestinal obstruction. Clinically apparent stenosis occurs in more than 30% of patients with...; 关键词：FIBROGENESIS AHEAD STENOSIS

Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium: 《Bone Research》2017年第2期123-136,共14页Melissa L Barron Mark S Rybchyn Sutharshani Ramesh Rebecca S Mason S Fiona Bonar Paul Stalley Sundeep Khosla Bernie Hudson Christopher Arthur Edward Kim Roderick J Clifton-Bligh Phillip B Clifton-Bligh; Fibrogenesis imperfecta ossium is a rare disorder of bone usually characterized by marked osteopenia and associated with variable osteoporosis and osteosclerosis, changing over time. Histological examination shows tha...; 关键词：ultrastructural CELLULAR CLINICAL

Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis被引量：2: 《Asian Pacific Journal of Tropical Medicine》2017年第5期423-432,共10页Naglaa M.El-Lakkany Walaa H.El-Maadawy Sayed H.Seif el-Din Olfat A.Hammam Salwa H.Mohamed Shahira M.Ezzat Marwa M.Safar Samira Saleh; supported by Theodore Bilharz Research Institute(grant number:ID-MS-99/A,2012,PI:Naglaa El-Lakkany); Objective:To investigate the antifibrotic role of rosmarinic acid(RA),a natural polyphenolic compound,on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods:The impact of RA on stellate cell line...; 关键词：Hepatic fibrosis Hepatic stellate cells Rosmarinic acid APOPTOSIS PROLIFERATION Profibrogenic markers

Silencing ofα-complex protein-2 reverses alcohol-and cytokine-induced fibrogenesis in hepatic stellate cells被引量：2: 《Liver Research》2017年第1期70-79,共10页Hao Liu Zhijin Chen Wei Jin Ashutosh Barve Yu-Jui Yvonne Wan Kun Cheng; This work was supported by an award(1R01AA021510)from the National Institutes of Health.; Background and aim:a-complex protein-2(aCP2)encoded by the poly(rC)binding protein 2(PCBP2)gene is responsible for the accumulation of type I collagen in fibrotic livers.In this study,we silenced the PCBP2 gene using ...; 关键词：Hepatic stellate cells Primary HSC MYOFIBROBLAST Liver fibrosis Poly(rC)binding protein(PCBP)2 Transforming growth factor(TGF)-b Platelet-derived growth factor(PDGF) Epidermal growth factor(EGF) LY2a09761 Migration

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