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Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathway: 《Journal of Pharmaceutical Analysis》2024年第8期1205-1221,共17页Xuedan Han Jialei Liu Yidong Zhang Eric Tse Qiyi Yu Yu Lu Yi Ma Lufeng Zheng; supported by the National Natural Science Foundation of China(Grant No.:82173842);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,China.; Anlotinib has strong antiangiogenic effects and leads to vessel normalization.However,the“window period”characteristic in regulating vessel normalization by anlotinib cannot fully explain the long-term survival bene...; 关键词：Anlotinib Extracellular matrix Interstitial fluid pressures Tumour solid pressure RhoA/ROCK

Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review: 《Journal of Pharmaceutical Analysis》2024年第7期972-982,共11页Shuangmeng Jia Jieshen Huang Wuyan Lu Yongen Miao Kehua Huang Chenzhang Shi Shuaijun Li Jiefeng Huang; funded by the National Natural Science Foundation of China(Grant No.:82070533).; Skin flaps are frequently employed in plastic and reconstructive surgery to address tissue defects.However,their low survival rates remain a challenge,attributed to vascular crisis and necrosis.Despite numerous studie...; 关键词：Skin flap Drug therapy Bibliometric analysis Global trends

Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy: 《Journal of Pharmaceutical Analysis》2024年第7期1024-1034,共11页Fulin Jiang Jingyu Liu Yagang Li Zihan Lu Qian Liu Yunhui Xing Janshon Zhu Min Huang Guoping Zhong; support provided by the National Natural Science Foundation of China(Grant No.:82173776);Natural Science Foundation of Guangdong Province,China(Grant No.:2021A1515010574);Guangdong Basic and Applied Basic Research Foundation,China(Grant No.:2021A1515110346).; Liquid chromatography-electrospray ionization tandem mass spectrometry(LC-ESI-MS)is a widely utilized technique for in vivo pharmaceutical analysis.Ionization interference within electrospray ion source,occurring betw...; 关键词：Liquid chromatography-electrospray ionization tandem mass spectrometry(LCESI-MS) DRUGS METABOLITES Ionization interference Quantitative analysis

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus: 《Journal of Pharmaceutical Analysis》2024年第3期431-434,共4页Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo; the National Key Research and Development Program of China(Grant No.:2022YFC3501700);the Key-Area Research and Development Program of Guangdong Province,China(Grant No.:2020B1111110001);the Youth Program of the National Natural Science Foundation of China(Grant No.:82003939).; Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the ce...; 关键词：injection DRUGS GLUCOCORTICOID CHEMOTHERAPY

Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy: 《Journal of Pharmaceutical Analysis》2023年第11期1233-1234,共2页Yirui Feng Bin Wang; Mesenchymal stromal cells(MSCs),known for their therapeutic bioactivity,find widespread application as cellular drugs for treating various diseases.MSCs obtained from patients or donors require extensive large-scale e...; 关键词：RABBIT DRUGS BATCH

A chiral metal-organic framework{(HQA)(ZnCl_(2))(2.5H_(2)O)}n for the enantioseparation of chiral amino acids and drugs: 《Journal of Pharmaceutical Analysis》2023年第4期421-429,共9页Xiangtai Zheng Qi Zhang Qianjie Ma Xinyu Li Liang Zhao Xiaodong Sun; This study was funded by the National Natural Science Foundation of China(Grant No.:82003705);the Shanghai Science and Technology Innovation Foundation(Grant Nos.:23010500200 and 23ZR1422700).; Chiral metal-organic frameworks(CMOFs)with enantiomeric subunits have been employed in chiral chemistry.In this study,a CMOF formed from 6-methoxyl-(8S,9R)-cinchonan-9-ol-3-carboxylic acid(HQA)and ZnCl_(2),{(HQA)(ZnCl...; 关键词：Capillary electrochromatography Metal-organic framework ENANTIOSEPARATION Chiral stationary phase Open-tubular column Dansyl amino acids

Capillary electrophoresis methods for impurity profiling of drugs:A review of the past decade被引量：2: 《Journal of Pharmaceutical Analysis》2022年第1期15-28,共14页Mansi Shah Nrupesh Patel Nagja Tripathi Vivek K.Vyas; The authors would like to thank Institute of Pharmacy,Nirma University,Ahmedabad,India for providing the necessary facilities。; Capillary electrophoresis(CE)is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures,analysis of biomolecules,and characterization of biopharmaceuticals.Currently,CE ...; 关键词：Capillary electrophoresis IMPURITIES Impurity profiling DRUGS

Possible therapeutic targets and promising drugs based on unsymmetrical hetaryl-substituted porphyrins to combat SARS-CoV-2: 《Journal of Pharmaceutical Analysis》2021年第6期691-698,共8页Yury A.Gubarev Natalya Sh.Lebedeva Elena S.Yurina Sergey A.Syrbu Aleksey N.Kiselev Mikhail A.Lebedev; funded by RFBR (Project No.: 20-0460067)。; Coronavirus disease 2019 is a serious disease that causes acute respiratory syndrome and negatively affects the central nervous system.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crosses the blood-brain...; 关键词：PORPHYRINS SARS-CoV-2 Molecular docking PHOTOINACTIVATION

A living cell-based fluorescent reporter for high-throughput screening of anti-tumor drugs: 《Journal of Pharmaceutical Analysis》2021年第6期808-814,共7页Ningning Tang Ling Li Fei Xie Ying Lu Zifan Zuo Hao Shan Quan Zhang Lianwen Zhang; financial support from the National Natural Science Foundation of China(Grant No.:31470795);Tianjin Municipal Science and Technology Commission(Grant No.:15JCYBJC24100);the“Fundamental Research Funds for the Central Universities”,Nankai University(Grant No.:63191148)。; Suppression of cellular O-linkedβ-N-acetylglucosaminylation(O-Glc NAcylation)can repress proliferation and migration of various cancer cells,which opens a new avenue for cancer therapy.Based on the regulation of insu...; 关键词：Fluorescent reporter High-throughput screening O-linkedβ-N-acetylglucosaminylation Anti-tumor drug Gene transcriptional regulation

Visualization analysis of lecithin in drugs based on electrochemiluminescent single gold microbeads被引量：1: 《Journal of Pharmaceutical Analysis》2021年第4期515-522,共8页Gen Liu Pei-Long Wang Hui Gao; supported by Anhui Provincial Natural Science Foundation(Grant Nos.2008085QB68 and 1808085QB29);Key Project of Provincial Natural Science Research Foundation of Anhui Universities(Grant Nos.KJ2018A0675 and KJ2018A0389);Foundation of State Key Laboratory of Analytical Chemistry for Life Science(Grant No.SKLACLS2003);Foundation of Henan Key Laboratory of Biomolecular Recognition and Sensing(Grant No.HKLBRSK1905)。; Fast and high-throughput determination of drugs is a key trend in clinical medicine.Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications,and microscopic an...; 关键词：LECITHIN Single particle Visualization analysis ELECTROCHEMILUMINESCENCE

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