云南高校图书馆联盟文献共享服务平台- O-METHYLTRANSFERASE

O-METHYLTRANSFERASE: 作品数：26被引量：71H指数：5; 导出分析报告; 相关领域：生物学更多>>; 相关作者：王台魏建华赵华燕宋艳茹马庆虎更多>>; 相关机构：中国科学院植物研究所天津市安定医院东北农业大学国家工程研究中心更多>>; 相关期刊：《Journal of Animal Science and Biotechnology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家自然科学基金天津市卫生局科技基金江苏省农业科技自主创新基金国家科技支撑计划更多>>

Structural and functional insights into the 20-O-methyltransferase of SARS-CoV-2: 《Virologica Sinica》2024年第4期619-631,共13页Jikai Deng Feiyu Gong Yingjian Li Xue Tan Xuemei Liu Shimin Yang Xianying Chen Hongyun Wang Qianyun Liu Chao Shen Li Zhou Yu Chen; supported by grants from the National Natural Science Foundation of China(82372223 and 82172243);the National Key R&D Program of China(2021YFF0702004);the Fundamental Research Funds for the Central Universities of China(2042022dx0003).; A unique feature of coronaviruses is their utilization of self-encoded nonstructural protein 16(nsp16),20-Omethyltransferase(20-O-MTase),to cap their RNAs through ribose 20-O-methylation modification.This process is c...; 关键词：SARS-CoV-2 nsp16/nsp10 20-O-Methyltransferase 3-Dimensional structure Molecular mechanism INHIBITORS

O-methyltransferase CbzMT catalyzes iterative 3,4-dimethylations for carbazomycin biosynthesis: 《Engineering Microbiology》2024年第2期51-61,共11页Baixin Lin Dashan Zhang Junbo Wang Yongjian Qiao Jinjin Wang Zixin Deng Lingxin Kong Delin You; supported by a grant from the National Key research and development Program of China (2021YFA0909500,2021YFC2100100);National Natural Science Foundation of China (32170077,32170075).; Carbazomycins(1-8)are a subgroup of carbazole derivatives that contain oxygen at the C3 and C4 positions and an unusual asymmetric substitution pattern.Several of these compounds exhibit antifungal and antioxidant act...; 关键词：One-strain-many-compounds(OSMAC) CARBAZOLE Carbazomycins O-METHYLTRANSFERASE Iterative methylation

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding被引量：1: 《Signal Transduction and Targeted Therapy》2024年第6期2819-2834,共16页Jikai Deng Shimin Yang Yingjian Li Xue Tan Jiejie Liu Yanying Yu Qiang Ding Chengpeng Fan Hongyun Wang Xianyin Chen Qianyun Liu Xiao Guo Feiyu Gong Li Zhou Yu Chen; partially sponsored by contributions from the National Key R&D Program of China(2021YFA1300800);the China NSFC projects(82172243,82341061,and 82372223);the Fundamental Research Funds for Central Universities(2042023kf1028 and 2042022dx0003).; Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion.However,the K-D-K-E catalytic motif of 2′-O-M...; 关键词：PATHOGENESIS IMPAIRED alterations

Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development被引量：1: 《Science China(Life Sciences)》2024年第3期565-578,共14页Zesen Lai Jianzheng Wang Ying Fu Menghan Wang Hong Ma Shiqing Peng Fang Chang; supported by the Ministry of Science and Technology,People’s Republic of China(2021YFA0909303);the National Natural Science Foundation of China(32270347,31822005,31870294)。; The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen development.The transcription factors (TFs) bHLH010/089/091 redundantly facilitat...; 关键词：anther development nuclear localization BHLH O-METHYLTRANSFERASE transcription factor homeostasis

Methylation in hangtaimycin biosynthesis and its antibacterial activities: 《Synthetic and Systems Biotechnology》2023年第4期682-687,共6页Minghe Luo Yulu Dong Zixin Deng Yuhui Sun; supported by National Key R&D Program of China(2018YFA0903200);General Program of National Natural Science Foundation of China(32370083);Natural Science Foundation of Chongqing CSTB(CSTB2022NSCQ-MSX0995);Graduate Innovation Program(GZLCX20232114)。; About two-thirds of small molecule drugs contain methyl group and it plays a very important role in the drug development.So,methyltransferases catalyzing the methylation have always attracted great attention.Hangtaimy...; 关键词：Hangtaimycin METHYLATION S-Adenosylmethionine-dependent METHYLTRANSFERASES FK506 methyltransferase type O-methyltransferase Antibacterial BIOSYNTHESIS

Functional characterization and key residues engineering of a regiopromiscuity O-methyltransferase involved in benzylisoquinoline alkaloid biosynthesis in Nelumbo nucifera被引量：3: 《Horticulture Research》2023年第2期241-251,共11页Yuetong Yu Yan Liu Gangqiang Dong JinZhu Jiang Liang Leng XianJu Liu Jun Zhang An Liu Sha Chen; supported by the National Natural Science Foundation of China(32170388);the Scientific and Technological Innovation project of China Academy of Chinese Medical Sciences(CACMS Innovation Fund CI2021A04108,CI2021A04515);the Fundamental Research Funds for the Central Public Welfare Research Institutes of China(ZZ13-YQ-057,ZXKT21006)。; Lotus(Nelumbo nucifera),an ancient aquatic plant,possesses a unique pharmacological activity that is primarily contributed by benzylisoquinoline alkaloids(BIAs).However,only few genes and enzymes involved in BIA biosy...; 关键词：BENZYL RESIDUES SKELETON

Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned,ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer被引量：1: 《Journal of Animal Science and Biotechnology》2023年第1期98-113,共16页Hao Wu Wendi Zhou Haijun Liu Xudai Cui Wenkui Ma Haixin Wu Guangdong Li Likai Wang Jinlong Zhang Xiaosheng Zhang Pengyun Ji Zhengxing Lian Guoshi Liu; Key Research and Development Project of Hainan Province(ZDYF2021XDNY174);Science and Technology Major Project of Inner Mongolia(2021ZD0023–1);National Transgenic Key Project of the Ministry of Agriculture of China(2018ZX0800801B)。; Background:SCNT(somatic cell nuclear transfer)is of great significance to biological research and also to the livestock breeding.However,the survival rate of the SCNT cloned animals is relatively low compared to other...; 关键词：Acetylserotonin-O-methyltransferase Dairy goat DNA methylation Gene editing Somatic cell nuclear transfer

OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila被引量：3: 《Journal of Integrative Plant Biology》2023年第1期133-149,共17页Xiaolong Hao Can Wang Wei Zhou Qingyan Ruan Chenhong Xie Yinkai Yang Chengyu Xiao Yan Cai Jingyi Wang Yao Wang Xuebin Zhang Itay Maoz Guoyin Kai; supported by the Major Science and Technology Projects of Breeding New Varieties of Agriculture in Zhejiang Province (2021C02074);National Natural Science Foundation of China (82003889, 31571735, 82073963, 81522049);National Key Research and Development Program of China (2018YFC1706203);Zhejiang Provincial Natural Science Foundation of China (LQ21H280004, LY20H280008);Zhejiang Provincial Ten Thousands Program for Leading Talents of Science and Technology Innovation (2018R52050);Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents;Research Project of Zhejiang Chinese Medical University (2021JKZDZC06);Opening Project of Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine (2021E10013)。; Camptothecin(CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. O...; 关键词：camptothecin biosynthesis metabolic engineering strategies Ophiorrhiza pumila plant secondary metabolism transcriptional regulation

过表达OsOMTL1(O-Methyltransferaselike 1)增强水稻苗期耐冷性: 《江西农业大学学报》2022年第4期807-812,共6页熊文涛罗世友沈雨民熊焕金吴小燕肖叶青陈明亮; 国家自然科学基金项目(31860367)。; 【目的】发现水稻中新的耐冷性基因,进一步解析水稻耐冷机制和培育耐冷水稻材料。【方法】在籼稻材料赣香B中过表达东乡野生稻中冷胁迫响应基因OsOMTL1,进行苗期耐冷性分析,并进行该基因的表达模式研究和基因型分析。【结果】过表达OsOM...; 关键词：水稻 OsOMTL1 过表达增强耐冷性耐冷性基因

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals被引量：3: 《Cellular & Molecular Immunology》2022年第5期588-601,共14页Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin; supported by the Hong Kong Health and Medical Research Fund grants COVID190121 to JF-WC and COVID190114 to D-YJ;the Hong Kong Research Grants Council grants C7142-20GF and T11-709/21-N to D-YJ.; Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated v...; 关键词：Live attenuated vaccine NSP16 2'-O-methyltransferase T-cell response Mucosal immunity Sterilizing immunity

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