This work was funded in part by the Natural Sciences and Engineering Research Council of Canada(Grant#2018-06338 to JFT);the Windsor Cancer Centre Foundation Seeds4Hope Seed Grant Funding Program(Grant#2017-03 to JFT);an Ontario Early Researcher Award(Grant#ER18-14-114 to JFT).
N-Alkyl ammonium resorcinarene chloride receptors,NARX_(4),have been shown to act as high-sensitivity detectors of pyrophosphate(PPi),a biomarker of disease,in aqueous media through the chloride-to-PPi exchange[NAR(Cl...
supported by the National Natural Science Foundation of China(21978144,21672208 and 21372218);the Support Plan on Science and Technology for Youth Innovation of Universities in Shandong Province(2019KJM002);the financial support from the Talents of High Level Scientific Research Foundation(6651118009 and 6631121010);the start-up fund for the Recruited Talent of Xihua University(Z201098).
The dearomative[5+1]annulation of 2-methylindoles with new five-membered synthons O-alkyl orthooxybenzaldehydes was developed unprecedentedly through cascade[1,5]-hydride transfer/dearomativecyclization in HFIP for th...
The authors gratefully acknowledge the financial support from the Council of Industrial Scientifc Research(CSIR),New Delhi,India,through an extramural research grant with the project number 02(0380)/19/EMR-II.D.C.;Priya thank the CSIR,New Delhi,for their senior research fellowships.
Easily accessible alkylbenzenes are highly valuable starting materials and solvents in synthetic organic chemistry for the production of pharmaceuticals,plastics,synthetic rubber,dyes,etc.
This work was supported by the National Natural Science Foundation of China(21702091);Science and Technology Innovation Development Plan of Yantai(2020MSGY114);Yantai“Double Hundred Plan”;The authors also thank the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province;The Graduate Innovation Foundation of Yantai University(YDYB2128)is gratefully acknowledged(for Y.-J.Hu).
An I_(2)-mediated[3+2]annulation of methyl-azaarenes with alkyl_(2)-isocyanoacetates or amino acid ester hydrochlorides has been demonstrated.This strategy involves CuN bond cleavage of isocyanides and can selectively...
We are grateful to the National Natural Science Foundation of China(U2004189);the Central Plains Science and Technology Innovation Leader Project(224200510009);the Program for Innovative Research Team in Science and Technology in Universities of Henan Province(20IRTSTHN005);the Natural Science Foundation of Henan Province(212300410364);the Henan Key Laboratory of Organic Functional Molecules and Drug Innovation;the 111 Project(D17007)for financial support.
A novel synthesis of spirocyclopropylpyrazole derivatives tethered with a trifluoromethyl unit through an unprecedented cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol(TFE)has bee...
Financial support from the National Natural Science Foundation of China(Grant No.22171143,21472096 and J1103306)is gratefully acknowledged.
Chiral 3-hydroxyoxindoles are biologically important molecular motifs which are frequently present in natural products and artificial compounds.Herein,we report an ultraviolet light-driven asymmetric vinylogous aldol ...
We thank the financial support from the Natural Science Foundation of Shandong Province(ZR2019MB049);the National Natural Science Foundation of China(No.21973055);The Taishan Scholar of Shandong Province(No.tsqn201812013);the Qilu Young Scholar of Shandong University are also acknowledged.
The mechanism and origins of regio-and stereoselectivities of Cu-catalyzed alkyne difunctionalization with CO_(2) and trialkyl boranes were computationally investigated.The results show that the vicinal addition to al...
supported by the Natural Science Foundation of Shandong Province(ZR2016JL012,ZR2020JQ07);the Scientific Research Foundation of Qingdao University of Science and Technology(1203043003457).
The development of new versatile alkylation reagents that can be transformed from diverse available chemical raw materials is highly desirable.Here,an efficient,metal-free organic photoredox-catalyzed direct alkylatio...
supported by the National Key Research and Development Program of China(2017YFA0503900);Shenzhen Government’s Plan of Science and Technology(JCYJ20170412110504956);the Shenzhen Fundamental Research Program(JCYJ20200109114225087);the National Science Fund for Distinguished Young Scholars(81525026);the Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products(2021B1212040015).
(±)-Cyclopeltains A and B(1 and 2),two pairs of unusual alkylated adenine derivatives,were isolated from the insect Cyclopelta parva and structurally characterized.1 and 2 both possess a 6/5/7/5 ring system arising f...
the National Natural Science Foundation of China(no.21672047 and 22101066);the State Key Laboratory of Urban Water Resource and Environment(no.2018DX02);the Science and Technology Plan of Shenzhen(JCYJ20210324133001004);the Natural Science Foundation of Guangdong(no.2020A1515010564);the Guangdong Province Covid-19 Pandemic Control Research Fund(no.2020KZDZX1218);supported by the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University.
An electrochemical defluorinative alkylation protocol ofα-trifluoromethyl alkenes is described.This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources includi...