HETEROCYCLIC

作品数：164被引量：182H指数：6
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相关机构：厦门大学兰州大学云南烟草科学研究院江苏师范大学更多>>
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New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
《Open Journal of Medicinal Chemistry》2022年第1期1-13,共13页Edward C. Lisic Sarah N. Grossarth Sarah B. Bowman Jessica L. Hill Michael W. Beck Joseph E. Deweese Xiaohua Jiang 
The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion...
关键词：TOPOISOMERASE Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones 
Induction of Lung Injury by Cooking Oil Fumes in Mice and the Protective Effects of Vitamin C
《Biomedical and Environmental Sciences》2021年第11期916-919,共4页LI Xiao Hong YU Xiao Li ZHOU Jian SHAN Hui OUYANG Chuan KE Hong Yang WU Tao Jin LI Wan Wei 
supported by Shandong Natural Science Foundation ZR2020MH336;Shandong medical and health development plan project 2019WS592;Shandong traditional Chinese medicine health plan project 2020M077;Shandong Sino US sports economy and Health Engineering Cooperation Research Center Project SDCA20191017;Weifang Medical College student innovation project science 2020011。
Cooking oil fumes(COF)are one of the most common air pollutants in indoor living environments in China.When oil is heated above 250°C,at least220 types of products are produced in the lampblack,including carcinogenic...
关键词：COOK HEATED HETEROCYCLIC 
Pharmacological characterization of JWX-A0108 as a novel type Ⅰ positive allosteric modulator of a7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model
《Acta Pharmacologica Sinica》2019年第6期737-745,共9页Li-lan Sun Tao-yi Yang Ning-ning Wei Wei Lu Wen-xuan Jiao Qi-qi Zhou Yong-zhen Miao Qin Gao Xin-tong Wang Qi Sun KeWei Wang 
research grants to KWW and Q S from the National Natural Science Foundation of China (NSFC 81573410,31370741, and 21572011);Ministry of Science and Technology of China (2013CB531302).
The a7 nicotinic acetylcholine receptor (a7 nAChR) is a ligand-gated Ca^2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Pharmacological enhancement of a7 nAChR function ...
关键词：a7 NACHR positive ALLOSTERIC modulator thiazolyl HETEROCYCLIC derivative JWX-A0108 electrophysiology PREPULSE inhibition of ACOUSTIC STARTLE spatial working memory cognitive deficits 
The biological potentials of substituted 1,2-diazines: a review on versatile pyridazine derivatives
《Journal of Chinese Pharmaceutical Sciences》2016年第10期707-725,共19页Mohammad Asif 
Many studies have been performed on the pyridazine(1,2-diazine) derivatives in the past decade. This heterocyclic nucleus possesses almost all types of pharmacological activities. This small and simple pyridazine nucl...
关键词：PYRIDAZINES HETEROCYCLIC Pharmacological activities 
Comparison of the Ability of Myricetin and Quercetin to Modulate the Oxidative DNA Damage Induced by Heterocyclic Amines被引量：2
《Food and Nutrition Sciences》2011年第4期356-365,共10页Ana Isabel Haza Angel Lui Coto Paloma Morales 
The aim of the present study was to compare the ability of the myricetin and quercetin to modulate the oxidative DNA damage induced by 2-amino-3, 8- dimethylimidazo [4,5-f] quinoxaline (8-MeIQx), 2-amino- 3, 4, 8- tri...
关键词：MYRICETIN QUERCETIN COMET Assay OXIDATIVE DNA Damage HETEROCYCLIC AMINES 
Malaria parasite carbonic anhydrase:inhibition of aromatic/heterocyclic sulfonamides and its therapeutic potential被引量：10
《Asian Pacific Journal of Tropical Biomedicine》2011年第3期233-242,共10页Sudaratana R Krungkrai Jerapan Krungkrai 
Supported by a grant from UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases(No.900142,930143,960103,970074,990490);the National Science and Technology Development Agency of Thailand(Career Development Award ID no.01-38-007);the Thailand Research Fund(BasicResearch Grants ID No.BRG/13/2543.BRG4580020.BRG 4880006)
Plasmodium falciparum(P.falciparum) is responsible for the majority of life-threatening cases of human malaria,causing 1.5-2.7 million annual deaths.The global emergence of drug-resistant malaria parasites necessitate...
关键词：Malaria PLASMODIUM FALCIPARUM Carbonic ANHYDRASE Carbonic ANHYDRASE inhibitor Aromalic/heterocyclic SULFONAMIDES ANTIMALARIAL agents Drug target Parasitic disease 
Antitumor Comparison of Three α-N-Heterocyclic Thiosemicarbazone Derivatives' Crystal Structures of Bis(2-acetylpyridine)thiocarbonohydrazone and Bis(imidazole-2-carboxaldehyde)thiocarbonohydrazone
《Chinese Journal of Structural Chemistry》2010年第9期1380-1386,共7页陈春玲 陈丹云 李明雪 牛景杨 
supported by the Natural Science Foundation of Henan Province,the Natural Science Foundation of Educational Department of Henan Province (2010B150003);China Postdoctoral Science Foundation (20090460847)
A series of ligands,HL1（2-acetylpyridine thiosemicarbazone）,H2L2（bis（2-acetyl-pyridine） thiocarbonohydrazone） and H2L3（bis（imidazole-2-carboxaldehyde） thiocarbonohydrazone） was synthesized.H2L2 and H2L3 were...
关键词：THIOSEMICARBAZONE thiocarbonohydrazone crystal structure cytotoxic activity 
Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins
《Chinese Chemical Letters》2007年第11期1335-1338,共4页Di Zao Li Yan Li Xiao Guang Chen Chen Gen Zhu Jing Yang Hong Yan Liu Xian Dao Pan 
A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 poss...
关键词：CAMPTOTHECIN SYNTHESIS Heterocyclic acid Antitumor activity 
A novel small molecule inhibitor targeted at Bcl-2被引量：1
《Science China(Life Sciences)》2007年第5期624-629,共6页JIN LiJi1, ZHANG ZhiChao2,3, WANG YuanYuan2, WEI MeiJiao1 & XU Qin2 1 School of Environmental & Biological Science & Technology, Dalian University of Technology, Dalian 116024, China 2 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China 3 State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjing, China 
Supported by the National Natural Science Foundation of China (Grant No. 30400106)
Recently, the heterocyclic compound 8-oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carboni-trile (S1) was synthesized and shown to induce apoptosis in both (H22) hematoma and (MCF-7) ade-nocarcinoma cells. The I...
关键词：apoptosis  Bcl-2  small molecule  HETEROCYCLIC COMPOUND 
Chem oprevention of 2-amino-1-methyl-6-phenyli-midazo[4,5-b]pyridine-induced carcinogen-DNA adducts by Chinese cabbage in rats被引量：2
《World Journal of Gastroenterology》1999年第2期50-54,共5页TAN Wen 1, LIN Dong Xin 1, XIAO Ying 2,FF Kadlubar 3 and CHEN Jun Shi 4 
Supported by the National Natural Science Foundation of China,No.39570627.
AIM The food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces colon and mammary gland tumors in rats and has been implicated in the etiology of human colorectal cancer. This study was co...
关键词：HETEROCYCLIC amine DNA ADDUCT Brassica vegetable COLONIC neoplasms CYTOCHROME P450 
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