TUNICAMYCIN

作品数：14被引量：54H指数：5
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相关领域：医药卫生更多>>
相关机构：空军军医大学（第四军医大学）解放军医学院复旦大学武汉大学更多>>
相关期刊：《Journal of Biomedical Research》《Neural Regeneration Research》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金上海市教育委员会重点学科基金更多>>
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Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro被引量：6
《Acta Pharmacologica Sinica》2016年第12期1525-1533,共9页Zheng MOU Yu-he YUAN Yu-xia LOU Yang HENG Ju-yang HUANG Cong-yuan XIA Yan GAO Cheng-gen ZHU Shi-feng CHU Piao LUO Jian-gong SHI Nai-hong CHEN 
This work was supported by the National Natural Science Foundation of China （No 81274122, 81373997, 81273629, 81473376, U1402221, and 81573640）, the National Mega-project for Innovative Drugs （No 2012ZX09301002-004）, the Program for Changjiang Scholars and Innovative Research Team in University （PCSIRT） （No IRT1007）, Beijing Natural Science Foundation （No 7131013 and 7161011）, and the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study （No BZ0150）.
Aim： Accumulation of α-synuclein （a-syn） in the brain is a characteristic of Parkinson＇s disease （PD）. In this study, we investigated whether treatment with tunicamycin, an endoplasmic reticulum （ER） stress i...
关键词：Gastrodia elata bibenzyl compound 20c PC12 cells TUNICAMYCIN Α-SYNUCLEIN ER stress Parkinson＇s disease NEUROPROTECTION 
Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generation被引量：2
《Acta Pharmacologica Sinica》2015年第4期497-506,共10页Hua-dong FAN Shao-peng CHEN Yu-xiang SUN Shao-hai XU Li-jun WU 
This work was supported by the National Basic Research Pro- gram of China （No 2014CB932002）, the CAS Strategic Priority Research Program （No XDB14030502）, the CAS/SAFEA Inter- national Partnership Program for Creative Research Teams, and the National Natural Science Foundation of China （No 81273004, 31470829, 20977093, and 10935009）. We thank Prof Daisuke ITO from Keio University （Japan） for providing the seipin plasmids.
Aim： Seipin is a protein that resides in endoplasmic reticulum, and involved in both lipid metabolic disorders and motor neuropathy. The aim of this study was to investigate the effects of mutant seipin on autopha~ s...
关键词：seipin LIPODYSTROPHY motor neuron disease GLYCOSYLATION lipid droplets AUTOPHAGY 3-MA TUNICAMYCIN ENDOPLASMICRETICULUM 
Inhibition of KL-6/MUC1 glycosylation limits aggressive progression of pancreatic cancer被引量：5
《World Journal of Gastroenterology》2014年第34期12171-12181,共11页Huan-Li Xu Xin Zhao Ke-Ming Zhang Wei Tang Norihiro Kokudo 
Supported by Grants from the National Natural Science Foundation of China,No.81302906;Beijing Natural Science Foundation,No.7144190;New Teacher Fund for Doctor Stations of Ministry of Education of China,No.20131107120019
AIM: To evaluate the significance of KL-6/MUC1 (a type of MUC1) glycosylation in pancreatic cancer progression.
关键词：Benzyl-N-acetyl-alpha-galactosaminide GLYCOSYLATION KL-6/MUC1 Pancreatic carcinoma TUNICAMYCIN 
IRE1α knockdown rescues tunicamycin-induced developmental defects and apoptosis in Xenopus laevis
《The Journal of Biomedical Research》2014年第4期275-281,共7页Li Yuan Jin Yu Xinxin Li Jiaojiao Feng Chenyang Yin Xinru Wang 
Inositol requiring enzyme-1 （IRE1） is highly conserved from yeasts to humans. Upon endoplasmic reticulum （ER） stress, IRE1 activates X-box-binding protein 1 （XBP1） by unconventional splicing of XBP1 mRNA, which ...
关键词：IRE1α Xenopus laevis TUNICAMYCIN developmental defects 
Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation被引量：6
《World Journal of Gastroenterology》2013年第11期1736-1748,共13页Xue-Li Pang Gang He Yang-Bo Liu Yan Wang Bo Zhang 
Supported by A Grant from the National Natural Science Foundation of China,No. 30870746
AIM:To investigate the role of endoplasmic reticulum(ER) stress in cancer radiotherapy and its molecular mechanism.METHODS:Tunicamycin(TM) was applied to induce ER stress in human esophageal cancer cell line EC109,and...
关键词：Endoplasmic reticulum stress TUNICAMYCIN ESOPHAGEAL cancer RADIOSENSITIVITY AUTOPHAGY APOPTOSIS 
Low levels of Bax inhibitor-1 gene expression increase tunicamycin-induced apoptosis in human neuroblastoma SY5Y cells被引量：1
《Neural Regeneration Research》2012年第17期1331-1337,共7页Dan Wu Peirong Wang Shiyao Wang 
supported by the National Natural Science Foundation of China,No. 30900802;the Research Fund for the Doctoral Program of Higher Education,No. 20070001801;the Leading Academic Discipline Project of Beijing Education Bureau;the Fund for Fostering Talents in Basic Science of the National Natural Science Foundation of China,No. J0630853/J0108
A human SH-SY5Y neuroblastoma cell line with a low level of Bax inhibitor-1 expression was established by lentivirus-mediated RNA interference and fluorescence-activated cell sorting. In control SH-SY5Y cells, tunicam...
关键词：Bax inhibitor-1 RNA interference SH-SY5Y endoplasmic reticulum stress TUNICAMYCIN apoptosis neural regeneration 
Ricinus communis agglutinin I functionalisation of poly(methyl methacrylate) (PMMA) as a substrate for microfluidic device
《Science China Chemistry》2012年第4期537-542,共6页ZHU DeRong LIU Xia WANG ZhenXin 
supported by National Basic Research Program of China (2011CB935800);the Jilin Provincial Science and Technology Department (20100701)
We report a functionalisation strategy which is able to generate Ricinus communis agglutinin 1 （RCA 120） modified PMMA microfluidic device for binding and culturing living cells. The functionalisation is achieved by...
关键词：poly(methyl methacrylate) (PMMA) microfluidic device Ricinus communis agglutinin I (RCA 120) TUNICAMYCIN PC 12 cell line 
Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2a signaling pathway被引量：8
《Journal of Geriatric Cardiology》2012年第3期258-268,共11页Chun-Lei Liu Xin Li Guo-Liang Hu Rui-Jun Li Yun-Yun He Wu Zhong Song Li Kun-Lun He Li-Li Wang 
This study was supported by the Ministry Science Foundation of the Chinese People's Liberation Army during the 12th Five-Year Plan Period
Objectives This study examined the protective effect of salubrinal and the mechanism underlying this protection against tunicamycin （TM）- and hypoxia-induced apoptosis in rat cardiomyocytes. Methods Neonatal rat car...
关键词：Endoplasmic reticulum stress Rat cardiomyocytes APOPTOSIS Salubrinal Cell protection 
Lectin Conjugated Gold Nanoparticle-based Colorimetric Assay for Studying the Interactions of Antibiotic with Living Cell被引量：1
《Chemical Research in Chinese Universities》2011年第2期193-197,共5页WANG Jin-e WANG Cheng-ke LIU Dian-jun WANG Zhen-xin 
Supported by the National Natural Science Foundation of China(No.20875087);the Fund of Chinese Academy of Sciences (No.KJCX2-YW-H11)
The interactions of antibiotic with living cells were studied by lectin conjugated gold nanoparticles（GNPs） based colorimetric assay. Because of the high affinity of lectin for saccharides, the lectin conjugated GNP...
关键词：Lectin-conjugated gold nanoparticle TUNICAMYCIN Colorimetric assay Living cell 
Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis被引量：1
《Protein & Cell》2010年第12期1093-1105,共13页Wenqing Chen Dongjing Qu Lipeng Zhai Meifeng Tao Yemin Wang Shuangjun Lin Neil P.J.Price Zixin Deng 
This work was supported by the National Basic Research Program(973 Program);the National Programs for High Technology Research Development Program(863 Program)from the Ministry of Science and Technology,the National Science Foundation of China,the Ministry of Education,the Science and Technology Commission of Shanghai Municipality,and Shanghai Leading Academic Discipline Project B203.
Tunicamycin,a potent reversible translocase I inhibitor,is produced by several Actinomycetes species.The tunicamycin structure is highly unusual,and contains an 11-carbon dialdose sugar and anα,β-1″,11′-glycosidic...
关键词：TUNICAMYCIN biosynthetic gene cluster high-throughput heterologous expression BIOASSAY combinatorial biosynthesis 
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