ENDOPLASMICRETICULUM

作品数：6被引量：58H指数：3
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相关领域：医药卫生更多>>
相关作者：黄海山更多>>
相关机构：温州医科大学更多>>
相关期刊：《Current Medical Science》《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Novel Role of ER Stress and Mitochondria Stress in Serum-deprivation Induced Apoptosis of Rat Mesenchymal Stem Cells被引量：3
《Current Medical Science》2018年第2期229-235,共7页Tong QIU Yan-yan HE Xiao ZHANG Xiao-lin MA 
This study was supported by grants from the National Natural Science Foundation of China （No. NSC31300791） and the Opening Project of Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients （No. HLPAI 2014006）.
The poor survival of mesenchymal stem cells （MSCs） compromises the efficacy of stem cell therapy. Growth factor deprivation is one of the important factors that have challenged the survival of donor MSCs in cell the...
关键词：mesenchymal stem cells serum deprivation mitochondria pathway endoplasmicreticulum stress synergistic effects 
Modulation of valosin-containing protein by Kyoto University Substances(KUS) as a novel therapeutic strategy for ischemic neuronal diseases被引量：1
《Neural Regeneration Research》2017年第8期1252-1255,共4页Masayuki Hata Hanako Ohashi Ikeda 
supported in part by research grants from the Astellas Foundation for Research on Metabolic Disorders,the Japan Foundation for Applied Enzymology,the Uehara Memorial Foundation,Mochida Memorial Foundation for Medical and Pharmaceutical Research,YOKOYAMA Foundation for Clinical Pharmacology(YRY1308);Japan Intractable Diseases Research Foundation,Japan Research Foundation for Clinical Pharmacology,ONO Medical Research Foundation,Takeda Science Foundation,Japan National Society for the Prevention of Blindness,a Grant-in-Aid for Young Scientists(24791850,to IHO;15K20255,to HM);the Ministry of Education,Culture,Sports,Science,and Technology of Japan(to IHO);the Ministry of Health,Labour and Welfare of Japan(to IHO)
Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate（ATP） depletion and subsequent i...
关键词：adenosine triphosphatase C/EBP homologous protein central retinal artery occlusion endoplasmicreticulum stress neuroprotective therapy retinal ganglion cell 
Seipin mutation at glycosylation sites activates autophagy in transfected cells via abnormal large lipid droplets generation被引量：2
《Acta Pharmacologica Sinica》2015年第4期497-506,共10页Hua-dong FAN Shao-peng CHEN Yu-xiang SUN Shao-hai XU Li-jun WU 
This work was supported by the National Basic Research Pro- gram of China （No 2014CB932002）, the CAS Strategic Priority Research Program （No XDB14030502）, the CAS/SAFEA Inter- national Partnership Program for Creative Research Teams, and the National Natural Science Foundation of China （No 81273004, 31470829, 20977093, and 10935009）. We thank Prof Daisuke ITO from Keio University （Japan） for providing the seipin plasmids.
Aim： Seipin is a protein that resides in endoplasmic reticulum, and involved in both lipid metabolic disorders and motor neuropathy. The aim of this study was to investigate the effects of mutant seipin on autopha~ s...
关键词：seipin LIPODYSTROPHY motor neuron disease GLYCOSYLATION lipid droplets AUTOPHAGY 3-MA TUNICAMYCIN ENDOPLASMICRETICULUM 
Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis被引量：14
《Acta Biochimica et Biophysica Sinica》2014年第10期902-910,共9页Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang 
This work was supported in part by grants from the National Natural Science Foundation of China （81360073, 81260063, 81360027）, and the Provincial Natural Science Foundation of Ningxia （NZ 13054, NZ 12174）.
Endoplasmic reticulum （ER） stress is emerging as an import- ant modulator of different pathological process and as a mechanism contributing to homocysteine （Hcy）-induced hepar injury. However, the molecular event ...
关键词：endoplasmic reticulum stress endoplasmicreticulum oxidoreductin loL HOMOCYSTEINE ATHEROSCLEROSIS 
The protective roles of autophagy in ischemic preconditioning被引量：27
《Acta Pharmacologica Sinica》2013年第5期636-643,共8页Wen-jun YAN Hai-long DONG Li-ze XIONG 
Acknowledgements This work was supported by the National Science Foundation for Distinguished Young Scholars （Grant 30725039） and the key project for the National Natural Science Foundation of China （Grant 30930091）.
a process for the degradation of protein aggregates and dysfunctional organelles, is required for cellular homeostasis and cell survival in response to stress and is implicated in endogenous protection. Ischemic preco...
关键词：AUTOPHAGY ischemia-reperfusion injury ischemic preconditioning AMPK MTOR BECLINL P13K MITOCHONDRIA endoplasmicreticulum stress reactive oxygen species （ROS） apoptosis 
Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes被引量：11
《Acta Biochimica et Biophysica Sinica》2013年第5期359-367,共9页Yujie Yang Yue Zhang Xiaoyu Liu Ji Zuo Keqiang Wang Junbo Ge 
Taurine, a conditionally essential amino acid, plays a critical role in cardiovascular function. Here we examined the effect of taurine on mitochondria and endoplasmic reticulum in rat cardiomyocytes during glucose de...
关键词：TAURINE taurine transporter glucosedeprivation mitochondrial oxidative stress endoplasmicreticulum stress 
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