EXCITATORY

作品数：95被引量：127H指数：5
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相关领域：医药卫生更多>>
相关作者：周华荣徐恩王云孔淑贞杨涛更多>>
相关机构：复旦大学广州医科大学伦敦大学学院山东中医药大学附属眼科医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression
《Neural Regeneration Research》2025年第11期3259-3272,共14页Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long 
supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY);the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL);the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...
关键词：basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission 
Graphene/F_(16)CuPc synaptic transistor for the emulation of multiplexed neurotransmission
《Journal of Semiconductors》2025年第1期215-223,共9页Zhipeng Xu Yao Ni Mingxin Sun Yiming Yuan Ning Wu Wentao Xu 
supported by the Shenzhen Science and Technology Program(No.JCYJ20210324121002008);the National Science Fund for Distinguished Young Scholars of China(No.T2125005);the National Key R&D Program of China(Nos.2022YFE0198200,2022YFA1204500,and 2022YFA1204504);the Natural Science Foundation of Tianjin(Nos.22JCYBJC01290 and 23JCQNJC01440);the Key Project of Natural Science Foundation of Tianjin(No.22JCZDJC00120);the Fundamental Research Funds for the Central Universities,Nankai University(Nos.BEG124901 and BEG124401);the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515110319);the Key Science and Technology Program of Henan Province(No.242102210171).
We demonstrate a bipolar graphene/F_(16)CuPc synaptic transistor(GFST)with matched p-type and n-type bipolar properties,which emulates multiplexed neurotransmission of the release of two excitatory neurotransmitters i...
关键词：synaptic transistor dual excitatory channels fast-switching plasticity multiplexed neurotransmission 
Non-coding RNAs in acute ischemic stroke:from brain to periphery
《Neural Regeneration Research》2025年第1期116-129,共14页Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng 
supported by the National Natural Science Foundation of China,Nos.82301486(to SL)and 82071325(to FY);Medjaden Academy&Research Foundation for Young Scientists,No.MJR202310040(to SL);Nanjing Medical University Science and Technique Development,No.NMUB20220060(to SL);Medical Scientific Research Project of Jiangsu Commission of Health,No.ZDA2020019(to JZ);Health China Buchang Zhiyuan Public Welfare Project for Heart and Brain Health,No.HIGHER202102(to QD).
Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic ...
关键词：acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs MICRORNAS NEUROINFLAMMATION non-coding RNAs oxidative stress 
Astrocyte chloride,excitatory-inhibitory balance and epilepsy
《Neural Regeneration Research》2024年第9期1887-1887,共1页Verena Untiet Maiken Nedergaard Alexei Verkhratsky 
Excitation and inhibition are at the core of brain function and malfunction.To sustain the activity of neuronal networks over time and space,glutamatergic excitation is balanced by GABAergic inhibition.The equipoise o...
关键词：EPILEPSY EXCITATORY excitation 
Neuroprotective effects of Shaoyao Gancao decoction against excitatory damage in PC12 cells based on the Src-NR2-nNOS pathway
《Journal of Traditional Chinese Medical Sciences》2024年第3期293-302,共10页Xiaoxu Fan Hongyan Ma Tiantian Zhou Min Fu Zhiyuan Qiao Yingtong Feng Zhen Wang Yiwei Shen Jingxia Wang 
supported by the National Natural Science Foundation of China(82074036).
Objective:To explore the neuroprotective effects of the Shaoyao Gancao decoction(SGD)against excitatory damage in PC12 cells and the role of the Src-NR2-nNOS pathway mediation by SGD in regulatingγ-aminobutyric acid(...
关键词：Shaoyao Gancao decoction PC12 N-Methyl-D-aspartic acid(NMDA) γ-aminobutyric acid(GABA) SRC NNOS 
Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory被引量：4
《Neural Regeneration Research》2024年第5期1133-1141,共9页Baicheng Zhao Hang Zhang Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You 
supported by the National Natural Science Foundation of China,No. 81771228;Shanghai Association of Science and Technology,Nos. 22WZ2501700 and 23WZ2504500 (all to LY)
Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/7.Brpf1,K...
关键词：behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current MRNA-SEQ 
A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response被引量：1
《Neuroscience Bulletin》2024年第3期310-324,共15页Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen 
supported by grants from the National Key R&D Program of China(2017YFE0103400);the National Nature Science Foundation of China(81470628).
Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various species.However,their role in transmitting visual information remains unclear.Here,we characterized PV+RGCs in the r...
关键词：Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway 
Transcriptional regulation in the development and dysfunction of neocortical projection neurons被引量：1
《Neural Regeneration Research》2024年第2期246-254,共9页Ningxin Wang Rong Wan Ke Tang 
supported by Guangdong Provincial Basic and Applied Basic Research Fund,No.2021A1515011299(to KT)。
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord...
关键词：autism spectrum disorders COGNITION DIFFERENTIATION excitatory circuits intellectual disability NEOCORTEX neurodevelopmental disorders projection neuron specification transcriptional regulation 
Core processing neuron-enabled circuit motifs for neuromorphic computing
《InfoMat》2023年第11期78-88,共11页Hanxi Li Jiayang Hu Anzhe Chen Yishu Zhang Chenhao Wang Beiduo Wang Yi Tong Jiachao Zhou Kian Ping Loh Yang Xu Tawfique Hasan Bin Yu 
National Natural Science Foundation of China,Grant/Award Numbers:92264106,U22A2076,62090034,DT23F0401,DT23F04008,DT23F04009;Young Scientists Fund of the National Natural Science Foundation of China,Grant/Award Number:62204219。
Based on brain-inspired computing frameworks,neuromorphic systems implement large-scale neural networks in hardware.Although rapid advances have been made in the development of artificial neurons and synapses in recen...
关键词：artificial intelligence hardware excitatory-inhibitory neurons neuronal circuit motifs speech separation spiking neural networks 
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits被引量：2
《Signal Transduction and Targeted Therapy》2023年第7期3427-3442,共16页Liying Chen Yingwei Xu Heming Cheng Zhongxia Li Nanxi Lai Menghan Li Yeping Ruan Yang Zheng Fan Fei Cenglin Xu Jiao Ma Shuang Wang Yan Gu Feng Han Zhong Chen Yi Wang 
This project was supported by grants from the National Natural Science Foundation of China(82022071,81973298 and 82204350);the National Key Research and Development Program of China(2020YFA0803902);the Natural Science Foundation of Zhejiang Province(LD22H310003).
Temporal lobe epilepsy(TLE),one common type of medically refractory epilepsy,is accompanied with altered adult-born dentate granule cells(abDGCs).However,the causal role of abDGCs in recurrent seizures of TLE is not f...
关键词：EPILEPSY seizures MAINTAIN 
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