SELF-EMULSIFYING

作品数：7被引量：53H指数：3
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相关领域：医药卫生更多>>
相关作者：张强吕娟丽张烜王坚成徐贵霞更多>>
相关机构：北京大学军事医学科学院更多>>
相关期刊：《Chinese Herbal Medicines》《Asian Journal of Pharmaceutical Sciences》《Journal of Chinese Pharmaceutical Sciences》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金泰国研究基金更多>>
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Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen
《Chinese Herbal Medicines》2019年第3期337-343,共7页Wan-jin Sun Peng Zhang Xiang-wei Qu Li-min Xu Chun-bao Yang Shi-ping Gu 
funded by general project on PLA (CBJ15J002)
Objective: To optimize a self-emulsifying drug delivery system(SEDDS) formulation for psoralen and isopsoralen(PSO and IPSO) isolated from Psoraleae Fructus.Methods: A D-optimal design was used to investigate the infl...
关键词：DESIRABILITY function D-optimal design ISOPSORALEN optimization PSORALEN SELF-EMULSIFYING DRUG delivery system 
Preparation and evaluation of alpha-mangostin solid self-emulsifying drug delivery system被引量：3
《Asian Journal of Pharmaceutical Sciences》2016年第1期225-226,共2页Kun Sodalee Pimchanok Sapsuphan Ratta Wongsirikul Satit Puttipipatkhachorn 
Alpha-mangostin(AMG),a natural xanthone extracted from Garcinia mangostana Linn,has a variety of pharmacological therapeutic effects such as antioxidant activity,antibacterial activity,anticancer,and anti-inflammatory...
关键词：Alpha-mangostin SOLID SELF-EMULSIFYING DRUG delivery system SOLUBILITY SOLID CARRIER 
Insoluble drug delivery strategies: review of recent advances and business prospects被引量：30
《Acta Pharmaceutica Sinica B》2015年第5期442-453,共12页Sandeep Kalepu Vijaykumar Nekkanti 
The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures i...
关键词：BIOAVAILABILITY COCRYSTALS SOLUBILITY Inclusion complexation Nanoparticles Self-emulsifying formulations PROLIPOSOMES 
A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution被引量：3
《Asian Journal of Pharmaceutical Sciences》2015年第2期121-127,共7页Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang 
Financial support from The Thailand Research Fund(grant number BRG5480013)is greatly acknowledged.
To enhance the dissolution of poorly soluble mefenamic acid,self-emulsifying formulation(SEF),composing of oil,surfactant and co-surfactant,was formulated.Among the oils and surfactants studied,Imwitor■ 742,Tween■ 6...
关键词：Self-emulsifying formulation Poorly water-soluble drug Mefenamic acid Drug dissolution 
Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin被引量：15
《Acta Pharmaceutica Sinica B》2014年第3期217-226,共10页Huiyi Wu Xiaoying Long Fei Yuan Li Chen Sujing Pan Yunjun Liu Yoshiko Stowell Xiaoling Li 
This work was supported by grants from the National Natural Science Foundation of China(No.30973953C1909)。
The aim of this study was to develop a formulation to improve the oral absorption of baicalin(BA)by combining a phospholipid complex(PC)and self-emulsifying microemulsion drug delivery system(SMEDDS),termed BA–PC–SM...
关键词：BAICALIN SMEDDS Phospholipid complex Caco-2 cell Single-pass intestinal per-fusion BIOAVAILABILITY 
Preparation and characterization of 9-nitrocamptothecin self-emulsifying microemulsion injection被引量：2
《Journal of Chinese Pharmaceutical Sciences》2007年第3期157-161,共5页吕娟丽 王坚成 张烜 张强 
National Natural Science Foundation of China (GrantNo.30430760);the 985 projects (Phase II) of the State Key Labo-ratory of Natural and Biomimetic Drugs (Peking University, China).
Aim To prepare a self-emulsifying microemulsion of 9-nitrocamptothecin （9-NC ME） for intravenous injection and investi- gation of its pharmacokinetic profiles in normal SD rats. Methods 9-NC ME was optimized in term...
关键词：9-NITROCAMPTOTHECIN Self-emulsifying microemulsion INJECTION PHARMACOKINETICS 
In vitro Dissolution and Pharmacokinetics in Beagle Dogs of a Self-Emulsifying Formulation of Tretinoin
《Journal of Chinese Pharmaceutical Sciences》2005年第2期105-109,共5页全东琴 徐贵霞 
Aim In vitro dissolution test and pharmacokinetics in beagle dogs wereconducted to assess the formulation of tretinoin in self-emulsifying systems. Methods Theconcentrations of tretinoin were determined by HPLC. A cro...
关键词：self-emulsifying systems TRETINOIN BIOAVAILABILITY DISSOLUTION 
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