DIOXYGENASE

作品数：56被引量：135H指数：5
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相关机构：天津医科大学西北农林科技大学河南科技大学仲恺农业技术学院更多>>
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Discovery of 4-Hydroxyphenylpyruvate dioxygenase inhibitors with novel pharmacophores
《Advanced Agrochem》2024年第4期344-350,共7页Tai-Li Yang Jin Dong Xin-Long Wang Jiangqing Dong Hong-Yan Lin 
National Key Research and Development Program of China(No.2023YFD1700500);National Natural Science Foundation of China(22377031);Hubei Provincial Science and Technology Plan Project(2022BEC051);Knowledge Innovation Program of Wuhan-Basic Research(No.2022013301015174);Key Research and Development Program of Hubei Province(2022BBA001).
4-Hydroxyphenylpyruvate dioxygenase(HPPD)is pivotal in tyrosine metabolism and essential for plant survival.Its inhibition leads to leaf bleaching and plant death.While current HPPD inhibitors are effective,they pose ...
关键词：METABOLISM PRECISE traditionally 
AbnI:Anα-ketoglutarate-dependent dioxygenase involved in brassicicene C-H functionalization and ring system rearrangement
《Chinese Chemical Letters》2024年第5期213-217,共5页Wenling Yuan Fengli Li Zhe Chen Qiaoxin Xu Zhenhua Guan Nanyu Yao Zhengxi Hu Junjun Liu Yuan Zhou Ying Ye Yonghui Zhang 
financially supported by the National Key R&D Program of China(Nos.2021YFA0910500,2021YFA0910503);the National Natural Science Foundation of China(Nos.22277035,32000045 and 81973205);the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Fundamental Research Funds for the Central Universities(No.2020kfyXJJS043).
We reported the characterization of a novel brassicicene diterpene biosynthetic gene cluster,which contains a uniqueα-ketoglutarate-dependent dioxygenase(αKGD)enzyme,AbnI.Our findings revealed that AbnI demonstrates...
关键词：Fungal diterpenes α-Ketoglutarate-dependent dioxygenase C-H functionalization REARRANGEMENT Brassicicenes 
Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer
《Signal Transduction and Targeted Therapy》2024年第4期1706-1720,共15页Jian Zhang Kejia Zhao Wenjing Zhou Ran Kang Shiyou Wei Yueli Shu Cheng Yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu 
supported by the National Natural Science Foundation of China (Grants 31771549 to Y.C.,82103251 to J.Z.,82203153 to K.Z.,and 82203574 to S.W.);the 1.3.5 Project for Disciplines of Excellence (Grants ZYGD18021,ZYJC18009,ZYJC21002,and ZYJC21015);the China Postdoctoral Science Foundation (Grants 2020TQ0210 and 2021M692268 to J.Z.);Natural Science Foundation of Sichuan Province (Grant 2022NSFSC1438 to J.Z.).
Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiti...
关键词：TET2 TKI RESISTANCE 
Qiteng Xiaozhuo granules(芪藤消浊颗粒)medicated serum inhibits excessive proliferation and promotes apoptosis of human glomerular mesangial cells by targeting fat mass and obesity associated proteins
《Journal of Traditional Chinese Medicine》2023年第6期1072-1080,共9页ZHUANG Xingxing LIU Tao WEI Liangbing SONG Junmei GAO Jiarong 
National Natural Science Foundation of China:Lnc NONRATG001910.2 Competitively Binds miR-339 to Regulate the Mechanism of Syk Involvement in the Pathogenesis of Chronic Nephritis and the Intervention of Qiteng Xiaozhuo Particles (No.81973546);the Key Scientific Research Projects of Natural Science in Colleges and Universities in Anhui Province:Study on the Mechanism of FTO-Mediated FOXO6 mRNA m6A Modification Regulating the Proliferation and Apoptosis of Glomerular Mesangial Cells (No.2022AH050747);Natural General Projects of Chaohu University:Expression and Target Analysis of miR-155-5p in Kidney Tissue of CGN Rats (No.XLY-201912)
OBJECTIVE:To explore whether fat mass and obesity associated proteins(FTO) is an important target of Qiteng Xiaozhuo granules(QTXZG,芪藤消浊颗粒) medicated serum in regulating proliferation and apoptosis of glomerular...
关键词：Qiteng Xiaozhuo granules alpha-ketoglutaratedependent dioxygenase FTO medicated serum cell proliferation apoptosis 
Transcriptomic analysis of wheat reveals possible resistance mechanism mediated by Yr10 to stripe rust
《Stress Biology》2023年第1期477-494,共18页Zhongyi Wu Gaohua Zhang Ran Zhao Qi Gao Jinchen Zhao Xiaoxu Zhu Fangyan Wang Zhensheng Kang Xiaojing Wang 
supported by National Key R&D Program of China(2021YFD1401000);National Natural Science Foundation of China(32172424);the 111 Project from the Ministry of Education of China(BP0719026).
Stripe rust,caused by Puccinia striiformis f.sp.tritici(Pst),is a catastrophic disease that threatens global wheat yield.Yr10 is a race-specific all-stage disease resistance gene in wheat.However,the resistance mechan...
关键词：TRANSCRIPTOME Yr10 Virus-induced gene silencing system (VIGS)system 4-hydroxyphenylpyruvate dioxygenase HPPD 
Discovery of tetrazolium nicotinamide derivatives as novel 4-Hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides被引量：2
《Advanced Agrochem》2023年第2期163-172,共10页Li-Jun Chen Guang-Yi Huang Jin Dong Zhuo-Mei Cai Bao-Qing Ye Qiong Chen Hong-Yan Lin 
the National Key Research and Development Program of China(No.2021YFD1700100);National Natural Science Foundation of China(No.22007035,21837001);Knowledge Innovation Program of Wuhan-Basic Research(No.2022013301015174);the Key Research and Development Program of Hubei Province(2022BBA001).
4-Hydroxyphenylpyruvate dioxygenase(EC 1.13.11.27,HPPD)is currently one of the popular targets of herbicide research,and herbicides targeting it have shown promising results in treating resistant weeds.However,the lon...
关键词：HPPD INHIBITOR PHARMACOPHORE Tetrazolium nicotinamide Herbicidal activity 
Regulation of A 9-cis-epoxycarotenoid Dioxygenase(NCED)Gene from Raspberry on High Salinity and Cold Tolerance
《Journal of Northeast Agricultural University(English Edition)》2023年第2期32-42,共11页Yang Guo-hui Li Bo-lin Wang Ze-min Yu Hang Wang Jia-ming Li Tie-mei 
Supported by the Postdoctoral Scientific Research Development Fund of Heilongjiang Province,China(LBH-Z21119);the Natural Science Fund Joint Guidance Project of Heilongjiang Province(LH2020C009);Young Talent Project of Northeast Agricultural University(19QC06)。
Abscisic acid(ABA)is a plant hormone that plays an important role in plant development and abiotic stress.The 9-cis-epoxycarotenoid dioxygenase(NCED)is a key rate-limiting enzyme in the ABA biosynthetic pathway.The ph...
关键词：9-cis-epoxycarotenoid dioxygenase RASPBERRY high salt cold 
QM/MM study on the O_(2)activation reaction of 4-hydroxylphenyl pyruvate dioxygenase reveals a common mechanism forα-ketoglutarate dependent dioxygenase
《Chinese Chemical Letters》2023年第5期461-465,共5页Linhui Li Suitian Lai Hongyan Lin Xinyun Zhao Xin Li Xi Chen Junjun Liu Guangfu Yang Changguo Zhan 
supported by the National Key R&D Program(No.2021YFD1700100);National Natural Science Foundation of China(Nos.21837001,21273089);the Open Project Fund of the Key Laboratory of the Pesticides and Chemical Biology of Central China Normal University(No.2018-A01);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the South-Central University for Nationalities(No.CZW20020)。
The dioxygen activation catalyzed by 4-hydorxylphenyl pyruvate dioxygenase(HPPD)were reinvestigated by using hybrid quantum mechanics/molecular mechanics(QM/MM)approaches at the B3LYP/6-311++G(d,p):AMBER level.These s...
关键词：4-Hydroxylphenyl pyruvate dioxygenase O_(2)activation QM/MM Mechanism Minimum energy crossing point 
A prodrug nanoplatform via esterification of STING agonist and IDO inhibitor for synergistic cancer immunotherapy
《Nano Research》2022年第10期9215-9222,共8页Madiha Zahra Syeda Tu Hong Min Zhang Yanfei Han Xiaoling Zhu Songmin Ying Longguang Tang 
supported by the National Natural Science Foundation of China(Nos.81920108001 and 81870007);Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents.
Cancer immunotherapy has made significant progress in the last few decades,revolutionizing oncology.However,low patient response rates and potential immune-related adverse events continue to be major clinical challeng...
关键词：PRODRUG esterase-responsive immunotherapy stimulator of interferon genes(STING) indoleamine 2 3 dioxygenase(IDO) 
Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer被引量：2
《World Journal of Gastroenterology》2022年第40期5845-5864,共20页Mohammad El-Harakeh Jessica Saliba Kawthar Sharaf Aldeen May Haidar Layal El Hajjar Mireille Kallassy Awad Jana G Hashash Margret Shirinian Marwan El-Sabban 
BACKGROUND Inflammatory bowel disease(IBD)constitutes a substantial risk factor for colorectal cancer.Connexin 43(Cx43)is a protein that forms gap junction(GJ)complexes involved in intercellular communication,and its ...
关键词：DEMETHYLATION Inflammation-induced carcinogenesis Ulcerative colitis Colorectal cancer CONNEXINS 
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