CELL-TYPE

作品数：37被引量：33H指数：3
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相关机构：中山大学陕西省人民医院中国科学院数学与系统科学研究院更多>>
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Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics
《Journal of Genetics and Genomics》2024年第11期1237-1251,共15页Lei Fan Boxin Liu Ru Yao Xia Gao Hongjuan Wang Sanjie Jiang Xiaomin Zheng Huan Chen Hongwei Hou Yong Liu Qingyuan Hu 
supported by the Major Project of Tobacco Biological Effects(552022AK0070,110202102014)。
Nicotine is widely recognized as the primary contributor to tobacco dependence.Previous studies have indicated that molecular and behavioral responses to nicotine are primarily mediated by ventral tegmental area(VTA)n...
关键词：Single-nucleus transcriptomics Ventral tegmental area Nicotine addiction Cell-type-specific alteration Mitochondrial dysfunction 
Single cell whole-genome sequencing of brain cells:age-and cell-type specific mutational profiles
《Signal Transduction and Targeted Therapy》2024年第9期3544-3545,共2页Melania Capasso N.Ahmad Aziz 
supported by DZNE core funding,the Helmholtz-Gemeinschaft Innovation Pool,Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy XC2151-390873048;CANTAR.The project“CANTAR”is receiving funding from the program“Netzwerke 2021,”an initiative of the Ministry of Culture and Science of the State of North Rhine-Westphalia.The sole responsibility for the content of this publication lies with the authors;funding from the European Union’s Horizon Europe research and innovation program under the MSCA Doctoral Networks 2021,No.101072759(FuEl ThE bRaiN In healtThY aging and age-related diseases,ETERNITY);supported by DZNE core funding,a European Research Council Starting Grant(#101041677);Alzheimer’s Association Research Grant(AARG-19-616534);the project“InVirtuo 4.0”by the Ministry of Culture and Science of the State of North Rhine-Westphalia.
In a recent study published in Cell,Ganz et al.shed new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome s...
关键词：LANDSCAPE cytes 
Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration
《Neural Regeneration Research》2024年第7期1411-1413,共3页Caleb A.Wood Nicholas M.Tran 
funded by the National Eye Institute(NIH) EY029360;the Whitehall Foundation;the TIRR Foundation;the Levy-Longenbaugh Research Award to NMT National Institute on Aging (NIH) F31AG067676 to CAW。
A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may pos...
关键词：selective TARGETED 
A review of cell-type specific circuit mechanisms underlying epilepsy被引量：1
《Acta Epileptologica》2024年第2期75-86,共12页Peilin Zhao Xiaomi Ding Lini Li Guohui Jiang 
supported by the NSFC project(No.81971220,82301647);the Science and Technology Department of Sichuan Province(No.2022NSFSC0724).
Epilepsy is a prevalent neurological disorder,yet its underlying mechanisms remain incompletely understood.Accu-mulated studies have indicated that epilepsy is characterized by abnormal neural circuits.Understanding t...
关键词：EPILEPSY Circuit mechanisms Cell-type specific Neuromodulatory 
The proteome landscape of the root cap reveals a role for the jacalin-associated lectin JAL10 in the salt-induced endoplasmic reticulum stress pathway被引量：1
《Plant Communications》2023年第6期179-196,共18页Krishna Kodappully Das Ankita Mohapatra Abin Panackal George Sreenivas Chavali Katja Witzel Eswarayya Ramireddy 
supported by IISER Tirupati and by an Early Career Research award from the Science and Engineering Research Board,Department of Science and Technology,Govt.of India(ECR/2016/001071)to E.R.K.K.D.acknowledges the CSIR-JRF fellowship and Bi-nationally supervised doctoral degree scholarship from DAAD(91730390)for her PhD.A.M.and A.P.G.acknowledge funding from IISER Tirupati for graduate studies.S.C.acknowledges funding from IISER Tirupati and the Ramalingaswami Re-entry Fellowship(BT/RLF/Re-entry/05/2018)Department of Biotechnology,Government of India.
Rapid climate change has led to enhanced soil salinity,one of the major determinants of land degradation,resulting in low agricultural productivity.This has a strong negative impact on food security and environmental ...
关键词：Arabidopsis root cap cell-type specific proteomics salt stress ER stress jacalin-associated lectin 
Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease被引量：1
《World Journal of Hepatology》2023年第12期1272-1283,共12页Sana Raza Sangam Rajak Rajani Singh Jin Zhou Rohit A Sinha Amit Goel 
Supported by Wellcome Trust/DBT India Alliance Fellowship,No.IA/I/16/2/502691;SERB,No.CRG/2022/002149;Young Scientist Grant,No.YSS/2020/000009/PRCYSS.
Autophagy,a cellular degradative process,has emerged as a key regulator of cellular energy production and stress mitigation.Dysregulated autophagy is a common phenomenon observed in several human diseases,and its rest...
关键词：AUTOPHAGY Non-alcoholic fatty liver disease HEPATOCYTES MACROPHAGES Hepatic stellate cells 
eQTL studies: from bulk tissues to single cells被引量：1
《Journal of Genetics and Genomics》2023年第12期925-933,共9页Jingfei Zhang Hongyu Zhao 
An expression quantitative trait locus (eQTL) is a chromosomal region where genetic variants are associated with the expression levels of specific genes that can be both nearby or distant. The identifications of eQTLs...
关键词：EQTL Bulk samples Single cell TISSUES Cell-type-specific Context-dependent 
Hidden in the parts:How the cell-type perspective reveals novel insights into plant-microbe interactions
《Molecular Plant》2023年第9期1359-1362,共4页Christian Froschel Wolfgang Droge-Laser 
The origin of multicellularity is considered an evolutionary milestone,as cellular differentiation and cooperation have allowed the emergence of specialized and unique functions.Some crucial biological processes invol...
关键词：FIGURE INSIGHT specialized 
Cell-type-specific transcriptomics reveals that root hairs and endodermal barriers play important roles in beneficial plant-rhizobacterium interactions
《Molecular Plant》2023年第7期1160-1177,共18页Eline H.Verbon Louisa M.Liberman Jiayu Zhou Jie Yin CornéM.J.Pieterse Philip N.Benfey loannis A.Stringlis Ronnie de Jonge 
the Netherlands Organization of Scientific Research through ALW Topsector Grant no.831.14.001(E.H.V.);a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research(L.M.L.);the NIH(5R01-GM-043778),the NSF(MCB-06-18304),the Gordon and Betty Moore Foundation and the Howard Hughes Medical Institute(P.N.B.);a postdoctoral fellowship from the Research Foundation Flanders(FWO 12B8116N)(R.d.J.);the NWO Green II Grant no.ALWGR.2017.002(R.d.J.);the Novo Nordisk Foundation Grant no.NNF19SA0059362(R.d.J.);the China Scholarship Council(CSC)scholarship no.201908320054(J.Z.);scholarship no.202006990074(J.Y.);the Technology Foundation Perspective Program Back2Roots grant no.14219(C.M.J.P.);the ERC Advanced Grant no.269072 of the European Research Council(C.M.J.P.);the NWO Gravitation Grant no.024.004.014(1.A.S.and C.M.J.).
Growth-and health-promoting bacteria can boost crop productivity in a sustainable way.Pseudomonas simiae WCS417is sucha bacterium that efficiently colonizes roots,modifiesthe architecture of the root systemto increase...
关键词：FACS cell-type-specific transcriptomics root immunity beneficial rhizobacteria SUBERIN root hair 
Comparative analysis of NovaSeq 6000 and MGISEQ 2000 single-cell RNA sequencing data
《Quantitative Biology》2022年第4期333-340,共8页Weiran Chen Md Wahiduzzaman Quan Li Yixue Li Guangyong Zheng Tao Huang 
This work was supported by Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB38050200 and XDA26040304).
Background:Single-cell RNA sequencing(scRNA-seq)technology is now becoming a widely applied method of transcriptome exploration that helps to reveal cell-type composition as well as cell-state heterogeneity for specif...
关键词：Single-cell RNA sequencing CELL-TYPE data processing PIPELINE PLATFORM 
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