TIPPING

作品数：60被引量：75H指数：5
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  • 学科=医药卫生—临床医学x
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Disease prediction by network information gain on a single sample basis
《Fundamental Research》2025年第1期215-227,共13页Jinling Yan Peiluan Li Ying Li Rong Gao Cheng Bi Luonan Chen 
supported by the National Natural Science Foundation of China(31930022,12131020,T2341007,T2350003);National Key R&D Program of China(2022YFA1004800);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040400);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004,2021B0909060002);Key-Area Research and Development Program of Guangdong Province(2021B0909060002);MajorKey Project of PCL(PCL2021A12),and JST Moonshot R&D(JPMJMS2021).
There are critical transition phenomena during the progression of many diseases.Such critical transitions are usually accompanied by catastrophic disease deterioration,and their prediction is of significant importance...
关键词：Tipping point Network information gain Dynamic network biomarker Disease prediction Network flow entropy Drug target 
Tipping the Scales
《China Weekly》2023年第12期26-29,共4页Yang Zhijie Xie Ying 
Rising prevalence of child and adolescent obesity has doctors warning that diseases like diabetes will become more common.Children need to be more active,and society needs to change its view of what a healthy child lo...
关键词：DOCTOR DISEASES OBESITY 
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation被引量：1
《Signal Transduction and Targeted Therapy》2023年第10期4889-4902,共14页Ting Zhang Huiling Zheng Danjuan Lu Guiwen Guan Deyao Li Jing Zhang Shuhong Liu Jingmin Zhao Ju-Tao Guo Fengmin Lu Xiangmei Chen 
This work is supported by grants from the National Natural Science Foundation of China(82272315);the Natural Science Foundation of Beijing Municipality(7222108);National Key R&D Program of China(2022YFA1303600).
The pregenomic RNA(pgRNA)of hepatitis B virus(HBV)serves not only as a bicistronic message RNA to translate core protein(Cp)and DNA polymerase(Pol),but also as the template for reverse transcriptional replication of v...
关键词：TRANSLATE TEMPLATE TRANSLATION 
Effect of 3D anchorage attachment on the alleviating tipping/extrusion of premolars for en-mass distalization of maxillary molars with clear aligners:A finite element study
《Medicine in Novel Technology and Devices》2023年第2期272-280,共9页Lurong Jia Chunjuan Wang Yao He Chao Wang Antonio Apicella Jinlin Song Yubo Fan 
This work was supported by the National Natural Science Foundation of China(Grant No.12072055,11872135,U20A20390,U22A20314);Natural Science Foundation of Beijing(Grant No.L212063);the Fundamental Research Funds for the Central Universities,the 111 Project(No.B13003);the National Research Program of China(Grant No.2022YFC2504200);Orthodontic research project of youth clinical research fund of Chinese Stomatological Association(Grant No.CSA-O2020-07);Municipal graduate tutor team construction project(dstd201903).
This study aimed to explore the optimal invisible orthodontic force system during the en-mass distalization of two maxillary molars to minimize the side effect of anchorage loss by changing the direction of the applic...
关键词：Clear aligner ORTHODONTICS 3D printing Three-dimensional finite element ATTACHMENTS Reinforced anchorage 
Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation被引量：4
《Signal Transduction and Targeted Therapy》2023年第2期730-743,共14页Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji 
We thank Drs.Tyler Jacks,Ronald A.DePinho,Kwok-kin Wong,and Lijian Hui for the generous gift of various mouse strains.We also thank Ruiqi Wang,Rui Liu,Pei Chen,Chao Zheng,and Jifan Shi for helpful discussion.This work was supported by the National Basic Research Program of China(Nos.2017YFA0505500 to H.J.and L.C.,2020YFA0803300 to H.J.);the National Natural Science Foundation of China(Nos.91731314,82030083,31621003,81872312,82011540007 to H.J.,12131020,31930022,12026608 to L.C.,82273093 to Z.F.,81871875,82173340 to L.H.,81802279 to H.H.,81902326 to X.W.,81402371 to Y.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB19020201 to H.J.,XDB38040400 to L.C.);Basic Frontier Scientific Research Program of Chinese Academy of Science(No.ZDBS-LY-SM006 to H.J.);International Cooperation Project of Chinese Academy of Sciences(No.153D31KYSB20190035 to H.J.);the Science and Technology Commission of Shanghai Municipality(No.21ZR1470300 to L.H.);the Youth Innovation Promotion Association CAS(No.Y919S31371 to X.W.);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(Nos.2021B0909050004,2021B0909060002 to L.C.);Major Key Project of PCL(No.PCL2021A12 to L.C.);JST Moonshot R&D Project(No.JPMJMS2021 to L.C.).
Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates...
关键词：SQUAMOUS HOMEOSTASIS LUNG 
Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage被引量：3
《Journal of Molecular Cell Biology》2021年第11期822-833,共12页Chengming Zhang Hong Zhang Jing Ge Tingyan Mi Xiao Cui Fengjuan Tu Xuelan Gu Tao Zeng Luonan Chen 
partially supported by the National Natural Science Foundation of China(31930022,31771476,12026608,12042104,and 11871456);the Strategic Priority Project of CAS(XDB38040400);the National Key R&D Program of China(2017YFA0505500);JST Moonshot R&D program(JP MJMS2021 to L.C.).
Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin disorders.Generally,skin response process to ultraviolet B(UVB...
关键词：single-sample network tipping point UVB irradiation living skin equivalent model time series data skin lightening 
Pushing past the tipping points in containment trajectories of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemics:A simple arithmetic rationale for crushing the curve instead of merely flattening it
《Infectious Disease Modelling》2020年第1期362-365,共4页Gerry F.Killeen 
This study was supported by an AXA Research Chair award to the author,kindly provided by the AXA Research Fund,and by Irish Aid,Deparment of Foreign Affairs and Trade,Government of Ireland through the Embassy of Ireland in Tanzania(Award number IA-TAN/2020/086).
Countries with ambitious national strategies to crush the curve of their Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)epidemic trajectories include China,Korea,Japan,Taiwan,New Zealand and Australia.Howe...
关键词：Coronavirus COVID SARS2 Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Model Epidemiology Outbreak ZOONOSIS Emerging infection 
Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma被引量：14
《Science Foundation in China》2018年第3期31-31,共1页
With the support by the National Natural Science Foundation of China,the research team directed by Prof.Xia JingLin (夏景林)at the Liver Cancer Institute,Zhongshan Hospital,Fudan University,and Prof.Chen LuoNan at Sha...
关键词：动态网络 癌症 中国科学院 显示 科学基础 生物化学 复旦大学 研究所 
Assessing the utility of the tipping point ratio to monitor HIV treatment programmes in the era of universal access to ART
《Infectious Disease Modelling》2018年第1期85-96,共12页Simon de Montigny Marie-Claude Boily Benoît RMasse Kate M.Mitchell Dobromir T.Dimitrov 
SM,BRM and DTD are supported by the Bill and Melinda Gates Foundation(OPP1110049);MCB,KMM and DTD are supported through the HPTN Modeling Center by subcontract from SDMC:HIV Prevention Trials Network funded by the U.S.National Institutes of Health(NIH UM1 AI068617).
Background:The epidemiological tipping point ratio(TPR)has been suggested as a useful indicator to monitor the scale-up of antiretroviral treatment(ART)programmes and determine when scale-up is sufficient to control t...
关键词：treatment maintained RETENTION 
Tipping the balance:Haemoglobinopathies and the risk ofdiabetes被引量：1
《World Journal of Diabetes》2016年第1期8-13,共6页Henry J Baldwin Aislinn E Green Kayleigh M Spellar Philip J Arthur Hannah G Phillips Jeetesh V Patel 
AIM: To establish a link between the risk of diabetes with haemoglobinopathies by examining available evidence of the effects of iron and blood glucose homeostasis from molecular to epidemiological perspectives.METHOD...
关键词：DIABETES FERRITIN Haemoglobinopathy Ironmetabolism MALARIA 
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