Metastatic castrate-resistant prostate cancer remains a disease hard to cure,and for this reason predictive tools to monitor disease progression and therapy response are an urgent need.In this respect,liquid biopsy on...
Our work referenced here was supported by funding from the Breast Cancer Research Foundation(BCRF16098),and by the Prevent Cancer Foundation(M1601095).
Liquid biopsies represent an attractive,minimally-invasive alternative to surgical sampling or complex imaging of breast cancer and breast cancer metastasis.Here we present a summary of the major biomarker components ...
We would like to thank Dr.Anthony E.Sisk Jr.at UCLA Genitourinary Pathology Unit for histological analysis.This study is funded by National Institutes of Health(Grant No:RO1 DE DE025474,P50CA092131,and P50CA211015),and CIRM Stem Cell Genomics Centers of Excellence Award.
Circulating cell-free DNAs(cfDNAs)are fragmented DNA molecules released into the blood by cells.Previous studies have suggested that mitochondria-originated cfDNA fragments(mt-cfDNAs)in cancer patients are more fragme...
Circulating tumor cells (CTC)have become an important biomarker in patients with advanced prostate cancer.CTC count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic cast...
Supported by Ricerca Sanitaria 2015 LILT and Beneficentia Foundation Stiftung,No.BEN2016/16
Breast cancer(BC) is the most common cancer and the second cause of death in women worldwide. Therapeutic options are increasing, but the response to treatments is not always efficient and the risk of recurrence cover...
Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in pl...
Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor...
supported by the Precision Medicine Research Program of the Chinese Academy of Sciences (Grant No. KJZD-EW-L14);the National Basic Research Program of China (973 Program; Grant Nos. 2012CB518302 and 2013CB911001);the National Natural Science Foundation of China (Grant Nos. 31540033 and 91019024);the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA01040407)
Detection of circulating tumor DNAs(ct DNAs) in cancer patients is an important component of cancer precision medicine ct DNAs. Compared to the traditional physical and biochemical methods, blood-based ct DNA detectio...
Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers ...
supported partly by the National Natural Science Foundation of China(No.81227901);the Natural Science Basic Research Plan in Shaanxi Province of China(No.2015JZ019);the Fundamental Research Funds for the Central Universities,National Cancer Institute of the National Institutes of Health(No.R00CA138914);National Natural Science Foundation(No. 81372216)
Cancer is a common cause of death worldwide.Despite significant advances in cancer treatments,the morbidity and mortality are still enormous.Tumor heterogeneity,especially intratumoral heterogeneity,is a significant r...