Prostate cancer is one of the most common cancers among males worldwide and a common cause of cancer related mortality in males. Bone metastasis from prostate cancer is common in advanced stage disease leading to majo...
sponsored by National Natural Science Foundation of China (82303396,82022051,82072972 and 81672883);Science and Technology Commission of Shanghai (22YF1408400);Shanghai Pilot Program for Basic Research (TQ20240208);Natural Science Foundation of Chongqing (CSTB2024NSCQ-JQX0009 and CSTB2024NSCQ-MSX0594);The Postdoctoral Foundation of China (2023T160122);Anti-cancer Association in Shanghai,Joint Foundation from Fudan University Shanghai Cancer Center (YJQN202102);Science&Techenology Department of Sichuan Province (2023NSFSC0705);the Fund of major military joint research project (2019LH 02);Shanghai municipal hospital emerging frontier joint research project (SHDC12024112)。
While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients,effective treatments are still lacking.Here,we identified homeobox C10(HOXC10)as a lynchpin in pan-KRAS-mutant lun...
BACKGROUND Osseous hemangiomas,especially those located in the manubrium,are rare benign tumors.In a review of the literature,only three case reports of sternal hemangioma were found.A precise diagnosis is difficult b...
supported by the National Cancer Institute(NCI)of the National Institutes of Health(NIH)(R03CA181893 and R01CA174926 to JLF,T32CA00923,P30CA023074);METAvivor(Translational Research Award,JLF);the Phoenix Chapter of ARCS Foundation(JNC);and the Louise Foucar Marshall Foundation Dissertation Fellowship(JNC).
Aim:Estrogen receptorα-positive(ER+)subtypes of breast cancer have the greatest predilection for forming osteolytic bone metastases(BMETs).Because tumor-derived factors mediate osteolysis,a possible role for tumoral...
Background: Elderly patients with primary intracranial osteolytic and externally growing atypical meningiomas are rare and easy to be misdiagnosed. Recently, a patient with an atypical meningioma was treated in our de...
Erdheim-Chester disease(ECD) is an uncommon, nonfamilial, non-Langerhans cell histiocytosis, which involves skeletal system and soft tissue usually in middle aged and elderly patients. The characteristic radiologic fe...
Supported by Grants from the Spanish Ministry of Economíay Competitividad-Instituto de Salud CarlosⅢ,No.PI12/02591;European Funds for Regional Development;the Spanish Health Thematic Networks of Cooperative Research in Cancer,No.RTICC RD12/0036/0058;Cellular Therapy,No.TerCelRD12/0019/0001,group 8;the Network of Centers for Regenera-tive Medicine and Cellular Therapy from Castilla y León;the Spanish Society of Hematology and Hemotherapy(to Garcia-Gomez A)
Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-presse...
Objectives: To report an epidemiology study and prognosis for metastatic bone tumor. Methodology: It was a descriptive, transversal study on records of patients hospitalized in Rheumatology and Oncology-Radiotherapy d...
supported by a grant from the National Natural Science Foundation of China(No.30772206)
The formation of osteolytic bone lesions is a key process for osteolytic cancer to metastasize to the bone and is under the control of a set of transcription factors. Recently, the inhibitor of differentiation 1 (Id1...
A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magne...