ARTESUNATE

作品数：73被引量：225H指数：8
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相关领域：医药卫生更多>>
相关作者：姚丽谢红靳秋月陈立军王静更多>>
相关机构：武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis被引量：2
《Journal of Pharmaceutical Analysis》2023年第7期817-829,共13页Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang 
support by the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research,China(Grant No.:2020YFE0205100);the National Key Research and Development Program of China(Grant Nos.:2020YFA0908000,2022YFC2303600);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(Grant No.:CW202002);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,China(Grant No.:ZYYCXTD-C-202002);the National Natural Science Foundation of China(Grant Nos.:82141001,82274182,82074098,82173914);the China Academy of Chinese Medical Sciences(CACMS)Innovation Fund,China(Grant Nos.:CI2021A05101,CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant No.:CI2021B014);the Science and Technology Foundation of Shenzhen,China(Grant No.:JCYJ20210324115800001);the Science and Technology Foundation of Shenzhen,China(Shenzhen Clinical Medical Research Center for Geriatric Diseases),the National Key R&D Program of China Key Projects for International Cooperation on Science,Technology and Innovation(Grant No.:2020YFE0205100);the Fundamental Research Funds for the Central Public Welfare Research Institutes,China(Grant Nos.:ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10),Shenzhen Governmental Sustainable Development Fund,China(Grant No.:KCXFZ20201221173612034);Shenzhen key Laboratory of Kidney Diseases,China(Grant No.:ZDSYS201504301616234);Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties,China(Grant No.:SZGSP001).
Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction.Studies on the therapeutic effect and mechanism of immunomodulatory drugs on th...
关键词：ARTESUNATE SEPSIS Single-cell RNA sequencing Immunomodulatory activity 
Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca^(2+)-NFATc1 signaling pathway被引量：21
《Acta Pharmacologica Sinica》2020年第2期229-236,共8页Xiang-zhou Zeng Yue-yang Zhang Qin Yang Song Wang Bin-hua Zou Yan-hui Tan Min Zou Shu-wen Liu Xiao-juan Li 
the National Natural Science Foundation of China(81773740,81073119,and 81611130078);the Natural Science Foundation of Guangdong Province,China(2015A030313287);the Natural Science Foundation of Hainan Province,China(817129).
In chronic infectious diseases caused by gram-negative bacteria,such as osteomyelitis,septic arthritis,and periodontitis,osteoclastic activity is enhanced with elevated inflammation,which disturbs the bone homeostasis...
关键词：ARTESUNATE OSTEOCLAST LPS PP2B-Aα CA^(2+) NFATc1 TLR4 RAW264.7 cells chronic INFECTIOUS diseases 
Anti-malaria drug artesunate protects bronchial epithelium from DNA damage induced by asthma被引量：1
《中国药理学与毒理学杂志》2015年第S1期25-26,共2页TzeKheeCHAN WNFeliciaTAN BevinPENGELWARD WSFredWONG 
The project supported by a NMRC grant NMRC/CBRG/0027/2012from the National Medical Research Council of Singapore,with additional support from the Singapore-MIT Alliance for Research and Technology
OBJECTIVE To investigate the genome protective effects of anti-malaria drug,artesunate in an experimental allergic asthma model.METHODS Mice were sensitized on day 0 and 7 and challenged on day 14 with 100μg house du...
关键词：ARTESUNATE HDM ASTHMA DNA damage cell death COMET 
In vitro and in vivo effect of artesunate against prostate cancer:Targetting STAT3 pathway to combat disease progression
《中国药理学与毒理学杂志》2015年第S1期81-82,共2页NachiyappanALAMELU KwangSeokAHN KodappullySivaramanSIVEEN AlanPremKUMAR GautamSETHI 
OBJECTIVE In prostate cancer(PCa),signal transducer and activator of transcription factor3(STAT3)has been strongly associated with tumor progression,through numerous means.Hence this allows STAT3 to be an important ta...
关键词：ANTITUMOR DU145 JAK SHP-1 
Anti-malarial drug,artesunate,as a novel therapeutic drug target for airway wall remodeling in asthma
《中国药理学与毒理学杂志》2015年第S1期54-55,共2页SherylTAN BenjaminONG ChangCHENG WanxingEugeneHO JohnK.CTAM AlastairG.STEWART TrudiHARRIS Wai-ShiuFredWONG ThaiTRAN 
OBJECTIVE Airway wall remodeling(AWR),which refers to structural changes in the airway,is a key characteristic of asthma.Airway smooth muscle(ASM)cell hypertrophy and hyperplasia contributes to AWR.Glucocorticoids,whi...
关键词：ASTHMA AIRWAY WALL REMODELING PI3K cyclin D1 
Artesunate and its emerging anti-neoplastic effects:beyond its role in attenuating tumor growth in osteosarcomas
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2012年第12期1029-1030,共2页Shailendra KAPOOR 
I read with great interest the recent article "Artesunate inhibits growth and induces apoptosis inhuman osteosarcoma HOS cell
关键词：药理学 性质 药物 实验 
The antiplasmodial effect of the extracts and formulated capsules of Phyllanthus amarus on Plasmodium yoelii infection in mice
《Asian Pacific Journal of Tropical Medicine》2011年第4期283-287,共5页Tolulope O Ajala Cecilia I Igwilo Ibrahim A Oreagba Oluwatoyin A Odeku 
Objective:To investigate the antiplasmodial activity of the extracts of Phyllanthus amarus(P. amarus) on Plasmodium yoelii(P.yoelii)(a resistant malaria parasite strain used in animal stuthes) infection in mice.Method...
关键词：ANTIPLASMODIAL activity PHYLLANTHUS amarus PLASMODIUM yoelli Artesunate/amodiaquine PYRIMETHAMINE 
Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo被引量：15
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2011年第4期247-255,共9页Qiang xu Zhao-xu LI Hui-qin PENG Zheng-wang SUN Rui-lin CHENG Zhao-ming YE Wei-xu 
This paper aims to investigate the effects of artesunate (ART) on growth and apoptosis in human osteosarcoma HOS cell line in vitro and in vivo and to explore the possible underlying mechanisms.Cell viability was meas...
关键词：ARTESUNATE Human osteosarcoma HOS cells APOPTOSIS Cell cycle Nude mice Chemotherapy 
Effects of Artesunate on Tracheal Smooth Muscle from the Guinea-pig
《Journal of Chinese Pharmaceutical Sciences》1997年第4期228-229,共2页Mao－ShengYang Jian－ChuXiao 
Artesunate is a derivative of qinghaosu, with a sesquiterpene structure. The specific action and the clinical uses of artesunate are on the preliminary stage. On the one hand, artesunate has specific action of both an...
关键词：Artesunate ester Tracheal smooth muscle ACETYLCHOLINE HISTAMINE Potassium chloride Cyclic AMP 
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