EPITOPES

作品数：96被引量：141H指数：7
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Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu 
supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。
Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...
关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES 
Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes
《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu 
the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.
The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...
关键词：ANTIBODIES inhibited MONOCLONAL 
Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus被引量：2
《Journal of Integrative Agriculture》2022年第7期2095-2105,共11页ZHAO Yu-hui WEN Xia LI Qi-bing JIANG Li WANG Guang-wen LIANG Li-bin WANG Xiu-rong CHEN Hua-lan LI Cheng-jun 
supported by the Natural Science Foundation of Heilongjiang Province,China(JQ2019C005);the National Natural Science Foundation of China(31702265 and 32172847)。
Monoclonal antibodies(mAbs) are widely used in virus research and disease diagnosis. The nucleoprotein(NP) of influenza A virus(IAV) plays important roles in multiple stages of the virus life cycle. Therefore, generat...
关键词：influenza A virus NUCLEOPROTEIN monoclonal antibody application 
Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection
《Bio-Design and Manufacturing》2021年第3期490-505,共16页Zainularifeen Abduljaleel Faisal A.Al-Allaf Syed A.Aziz 
The World Health Organization has declared the rapidly spreading coronavirus to be a global pandemic.The FDA is yet to approve a vaccine for human novel coronavirus.Here,we developed a peptide-based vaccine and used h...
关键词：COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy 
Targeting multiple epitopes on the spike protein:a new hope for COVID-19 antibody therapy
《Signal Transduction and Targeted Therapy》2020年第1期778-779,共2页Yeping Sun Bostjan Kobe Jianxun Qi 
supported by the Strategic Priority Research Program of CAS(XDB37030204);the National Key Research and Development Program of China(2016YFD0500305);the Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control(2020XGZX031).
Lihong Liu et al.1 from Columbia University recently reported in Nature the isolation of a collection of 19 SARS-CoV-2-neutralizing monoclonal antibodies(mAbs)from five infected patients with high plasma virus-neutral...
关键词：al ANTIBODIES NEUTRAL 
Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo被引量：1
《Cellular & Molecular Immunology》2017年第5期432-442,共11页Ronit Mazor Devorah Crown Selamawit Addissie Youjin Jang Gilad Kaplan Ira Pastan 
Antibodies against the toxin portion of recombinant immunotoxins （RIT） reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SSIP to produce LMB...
关键词：anti-drug antibodies deimmunization IMMUNOGENICITY mouse epitopes T-cell epitopes 
Novel Immunogenic Epitopes in the NaPi-IIb Protein: Production of Monospecific Antibodies Using Synthetic Peptides Outlined on Isoform Specific Regions of the Type IIb Sodium-Dependent Phosphate Transporter (NaPi-IIb)
《Journal of Cancer Therapy》2016年第2期129-151,共23页Ângela Alice Amadeu Megale Jorge Mário da Costa Ferreira Júnior Letícia Batista Azevedo Rangel Maria Del Pilar Estevez Diz Max Senna Mano Paulo Marcelo Gehm Hoff Priscila Hess Lopes Roberto Jun Arai Wilmar Dias da Silva 
NaPi-IIb is a multiple passage protein membrane which is primarily responsible for phosphate uptake in the kidney and in the small intestine. Beyond its physiological functions, their involvement with carcinogenesis w...
关键词：NaPi2b Peptides ANTIBODIES Ovarian Cancer 
Generation and Characterization of a Panel of Monoclonal Antibodies Against Distinct Epitopes of Human CD146
《生物物理学报》2009年第S1期231-232,共2页Ping Wang1, Xiyun Yan.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China 
CD146 (MUC18, Mel-CAM/MCAM) is a transmembrane protein, originally identified as a biomarker of melanoma, and plays an important role in cancer invasion and metastasis.
关键词：HUMAN CD146 antibody different EPITOPES 
Monoclonal Antibodies Against Human Brain Acetylcholinesterase and Properties of Epitopes Directed by the Antibodies
《Chinese Science Bulletin》1994年第16期1392-1397,共6页朱美财 孙曼霁 辛颜彬 方允中 
Project supported by the National Natural Science Foundation of China.
Acetylcholinesterase (AChE, EC, 3, 1, 1, 7,) is distributed in human nervous system, and also in non-nervous systems such as erythrocytes and serum. It is a kind of secretory as well as membrane-combining protein. The...
关键词：human brain ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY epitope. 
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