CYCLOOXYGENASE-1

作品数：8被引量：62H指数：5
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相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Hepatobiliary & Pancreatic Diseases International》更多>>
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Increased susceptibility of aging gastric mucosa to injury and delayed healing:Clinical implications被引量：9
《World Journal of Gastroenterology》2018年第42期4721-4727,共7页Andrzej S Tarnawski Amrita Ahluwalia 
Merit Review Award from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service,No.I01 BX000626-05A2 to Tarnawski AS
In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thromb...
关键词：AGING gastric MUCOSA INJURY Low dose aspirin Platelets CYCLOOXYGENASE-1 CYCLOOXYGENASE-2 THROMBOXANE A-2 
New flavonoids and methylchromone isolated from the aerial parts of Baeckea frutescens and their inhibitory activities against cyclooxygenases-1 and -2被引量：1
《Chinese Journal of Natural Medicines》2018年第8期615-620,共6页ZHOU Jun-Neng YAN Ming GAO Peng HOU Ji-Qin PHAM Thi-Anh WANG Hao 
supported by the National Natural Science Foundation of China(No.81573309)
In the present study,we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens,which resulted in the isolation of two new flavonoid glycosides,myricetin 3-O-(5'-O-ga...
关键词：Baeckea frutescens Flavonoid Methylchromone CYCLOOXYGENASE-1 CYCLOOXYGENASE-2 
Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1(COX-1) inhibitors被引量：1
《Chinese Chemical Letters》2013年第2期120-122,共3页Xue-Ping Chu Qing-Fa Zhou Shen Zhao Fei-Fei Ge Mian Fu Jia-Peng Chen Tao Lu 
the National Natural Science Foundation of China(No. 21102179);Fundamental Research Funds for the Central Universities(No.JKZ2011011) for the financial support
Received 2 December 2012 Received in revised form 21 December 2012 Accepted 27 December 2012 Available online 4 February 2013
关键词：3-Amino-2-pyroneBiological activityCOX-l-selective inhibitorSynthesis 
The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity
《Journal of Genetics and Genomics》2010年第2期117-123,共7页Sean Phipps Michael J. Turner Daniel L. Simmons 
Cyclooxygenases are encoded by COX-1 and COX-2. They share over sixty percent sequence identity in human and are similar to each other in their crystallographic structures. One major difference in the primary structur...
关键词：COX-1 COX-2 DIMERIZATION GLYCOSYLATION aspirin KM VMAX 
Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats被引量：6
《Cell Research》2009年第11期1269-1278,共10页Bin Wu Lixian Zeng Ying Lin Zhuofu Wen Guihua Chen Ryuichi Iwakiri Kazuma Fujimoto 
Portal hypertension （PHT） gastropathy is a frequent complication of fiver cirrhosis and one of the leading causes of death from cirrhosis. Apoptosis is widely considered to be an active energy-dependent mode of cell...
关键词：tumor necrosis factor-α Fas ligand tumor necrosis factor-related apoptosis-inducing ligand CASPASE-8 caspase-3 
Cyclooxygenases in hepatocellular carcinoma被引量：25
《World Journal of Gastroenterology》2006年第32期5113-5121,共9页Melchiorre Cervello Giuseppe Montalto 
Supported by a grant from the Associazione Italiana per la Ricerca sul Cancro and from the Italian Ministero dell'Universitàedella Ricerca Scientifica (ex 60%, year 2003)
Many epidemiological studies demonstrate that treatment with non-steroidal anti-inflammatory drugs （NSAIDs） reduce the incidence and mortality of certain malignancies, especially gastrointestinal cancer. The cycloox...
关键词：CYCLOOXYGENASE-2 CYCLOOXYGENASE-1 Hepatocellular carcinoma Non-steroidal antiinflammatory drugs Inhibit cyclooxygenase-2 
Expression and enzyme activity determination of human cyclooxygenase-1 and -2 in a baculovirus-insect cell system被引量：5
《Acta Pharmacologica Sinica》2004年第8期1000-1006,共7页Wei-yuZHANG Xin-ningYANG Dao-zhongJIN Xing-zuZHU 
AIM: To develop an in vitro intact cell-based assay for screening selective cyclooxygenase inhibitors. METHODS: Human cyclooxygenase-1 (hCOX-1) and cyclooxygenase-2 (hCOX-2) genes were cloned from human monocyte cell ...
关键词：BACULOVIRUSES prostaglandin-endoperoxide synthase non-steroidal anti-inflammatory agents  prostaglandins drug inhibition 
Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma被引量：15
《Hepatobiliary & Pancreatic Diseases International》2002年第3期429-433,共5页Gao-Song Wu Ju-Hua Wang Zheng-Ren Liu Sheng-Quan Zou the Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 
Objective: To investigate the expression of cyclooxy- genase-1 (COX-1) and cyclooxygenase-2 (COX-2) in extra-hepatic cholangiocarcinoma and the relation- ship between their expression and clinicopathological parameter...
关键词：CYCLOOXYGENASE CHOLANGIOCARCINOMA IMMUNOHISTOCHEMISTRY carcinogenes 
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