CACHEXIA

作品数：60被引量：180H指数：8
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相关领域：医药卫生更多>>
相关机构：中国人民解放军空军军医大学第一附属医院天津医科大学更多>>
相关期刊：《Frontiers in Biology》《World Journal of Experimental Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家科技支撑计划更多>>
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Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress
《Genes & Diseases》2025年第2期319-336,共18页Xiaofan Gu Shanshan Lu Shuang Xu Yiwei Li Meng Fan Guangyu Lin Yiyuan Liu Yun Zhao Weili Zhao Xuan Liu Xiaochun Dong Xiongwen Zhang 
supported by the National Natural Science Foundation of China (No.82373317,82374085,82303818,22377087);the Science and Technology Commission of Shanghai Municipality,China (No.20S11902200,16DZ2280100);the Natural Science Foundation of Shanghai Municipality,China (No.23ZR1460500);the China Postdoctoral Science Foundation (No.2023M731106)。
Cancer-associated cachexia(CAC)is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss,which accounts for one-third of cancer-related deaths.No effective therapeutic approach that could ful...
关键词：Cancer-associated cachexia Fat lipolysis Muscle atrophy NF-κB signaling Oxidative stress Z526 
Exploring the therapeutic effect of Xiaoyan d ecoction on lung cancer cachexia skeletal muscle atrophy based on L3-SMI
《Cancer Advances》2024年第15期1-9,共9页Qing-Peng Jin Yun-Chao Zhang Shi-Yu Wang Hao-Jian Zhang Shang-Heng Liu Wen-Hao Liu Na Lu 
National Natural Science Foundation of China(No.81303095);Tianjin Science&Technology Program(No.12ZCDZSY15800).
Background:Lung cancer cachexia has received widespread attention as one of the most common complications in patients with advanced lung cancer.As a multifactorial syndrome,lung cancer cachexia is characterized by a p...
关键词：lung cancer cachexia Xiaoyan decoction skeletal muscle index network pharmacology 
Treatment of choice for malignant gastric outlet obstruction: More than clearing the road
《World Journal of Gastrointestinal Endoscopy》2024年第11期587-594,共8页Li Jiang Xiao-Ping Chen 
In this editorial,we comment on the in-press article in the World Journal of Gas-trointestinal Endoscopy concerning the treatment of malignant gastric outlet obstruction(mGOO).The original theory of treatment involves...
关键词：Malignant gastric outlet obstruction Surgical gastroenterostomy Endoscopic stenting Endoscopic ultrasound-guided gastroenterostomy Stomach-partitioning gastrojejunostomy Anorexia‒cachexia syndrome 
Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predicts Cachexia and Prognosis in Hepatocellular Carcinoma Patients
《Current Medical Science》2024年第5期1018-1025,共8页Xin-xiang LI Bing LIU Yu-fei ZHAO Yang JIANG Ying CUI Xin-gui PENG 
supported by grants from National Natural Science Foundation of China(No.82272064);Jiangsu Provincial Science and Technique Program(No.BK20221461);Zhongda Hospital Affiliated to Southeast University,Jiangsu Province High-level Hospital Paring Assistance Construction(No.zdlyg08).
Objective Cachexia occurs in approximately half of hepatocellular carcinoma(HCC)patients as the disease progresses and is correlated with a poor prognosis.Therefore,early identification of HCC patients at risk of deve...
关键词：CACHEXIA hepatocellular carcinoma functional liver imaging score magnetic resonance imaging 
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia
《Signal Transduction and Targeted Therapy》2024年第10期4667-4682,共16页Xu Chen Qingnan Wu Wei Gong Shaolong Ju Jiawen Fan Xiaohan Gao Xingyang Liu Xiao Lei Siqi Liu Xiangdong Ming Qianyu Wang Ming Fu Yongmei Song Yan Wang Qimin Zhan 
National Key Research and Development Program of China#1 under Y.W.[number 2022YFC3400904];National Natural Science Foundation of China#2 under Q.Z.[number 81988101 and 81830086];National Natural Science Foundation of China#3 under Y.W.[number 82173152];Research Unit of Molecular Cancer Research,Chinese Academy of Medical Sciences,CAMS Innovation Fund for Medical Sciences#4 under Q.Z.[number 2019-I2M-5-081];Science Foundation of Peking University Cancer Hospital#5 under Q.Z.[number 17-01].
Cachexia,which affects 50–80%of cancer patients,is a debilitating syndrome that leads to 20%of cancer-related deaths.A key feature of cachexia is adipose tissue atrophy,but how it contributes to the development of ca...
关键词：CANCER ELEVATED white 
Understanding cachexia and its impact on lung cancer and beyond
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第2期95-105,共11页Meiting Yue Zhen Qin Liang Hu Hongbin Ji 
supported by grants from the Key Research&Develop-ment Program of China(Nos.2022YFA1103900 and 2020YFA0803300 to H.J.);the National Natural Science Foundation of China(Nos.82341002 to H.J.,32293192 to H.J.,82030083 to H.J.,82173340 to L.H.,82273400 to Y.J.,and 32100593 to X.T.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(No.ZDBS-LY-SM006 to H.J.).
Cancer cachexia is a multifactorial syndrome characterized by loss of body weight secondary to skeletal mus-cle atrophy and adipose tissue wasting.It not only has a significant impact on patients’quality of life but ...
关键词：Cancer cachexia Staging systems MEDIATORS Signaling pathways Therapeutic strategies 
Prognostic value of cachexia defined by the Asian Working Group for Cachexia criteria in patients with gastric cancer
《Journal of Nutritional Oncology》2024年第2期63-71,I0001,共10页Hai-Lun Xie Li-Shuang Wei Shu-Yao Wang Chang-Hong Xu Guo-Tian Ruan He-Yang Zhang Han-Ping Shi Jun-Qiang Chen 
supported by the Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001).
Background:The Asian Working Group for Cachexia(AWGC)criteria are newly proposed diagnostic standards specifically designed for Asian populations.This research focused on validating the predictive value of the AWGC cr...
关键词：CACHEXIA AWGC criteria SURVIVAL 90-Day mortality Gastric cancer 
Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus
《Journal of Pharmaceutical Analysis》2024年第3期431-434,共4页Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo 
the National Key Research and Development Program of China(Grant No.:2022YFC3501700);the Key-Area Research and Development Program of Guangdong Province,China(Grant No.:2020B1111110001);the Youth Program of the National Natural Science Foundation of China(Grant No.:82003939).
Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the ce...
关键词：injection DRUGS GLUCOCORTICOID CHEMOTHERAPY 
Cancer cachexia:Focus on cachexia factors and inter-organ communication
《Chinese Medical Journal》2024年第1期44-62,共19页Yongfei Wang Zikai Dong Ziyi An Weilin Jin 
supported by the High-Level Talent Introduction Funds from the First Hospital of Lanzhou University.
Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammato...
关键词：Cancer cachexia Cancer cachexia factors Inter-organ communication Tumor ecosystem Tumor microenvironment 
Impact of weight Loss on the progression of cancer cachexia and the patient prognosis:insights from a retrospective study被引量：1
《Journal of Nutritional Oncology》2023年第4期196-204,共9页Wei Ji Yu-Wei He Xiang-Liang Liu Wei Li 
provided by the Doctor of Excellence Program from The First Hospital of Jilin University(No.JDYY-DEP-2022024)
Background:Cachexia is a metabolic state with weight and muscle mass loss as its basic characteristics.This study aims to reveal the influ-ence of weight loss on the progression of cancer cachexia,and to determine its...
关键词：Cancer CACHEXIA Weight loss Body mass index SURVIVAL 
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