This work was supported by the Strategic Priority Research Program of the Chinese Academy of Science(XDA16020400 to P.H.);Ministry of Science and Technology of China(2017YFA0102700 to P.H.);the National Natural Science Foundation of China(32170804 to P.H.and 81200355 to W.Y.);CAS-Youth Innovation Program Association(2016246 to W.Y.);Shanghai Natural Science Foundation(18ZR1446300 to W.Y.).
Long non-coding(lnc)RNA plays important roles in many cellular processes.The function of the vast majority of lncRNAs remains unknown.Here we identified that lncRNA-1700113A16RIK existed in skeletal muscle stem cells(...
supported by the National key research and development program of China(Grant No.2018YFD0500402);the National Natural Science Foundation of China(Grant No.31790412,Grant No.31672431);the National Key Basic Research Program of China(2013CB127302。
Background:Long non-coding RNAs(lncRNAs)are emerging key regulators involved in a variety of biological processes such as cell differentiation and development.The balance between myogenesis and adipogenesis is crucial...
This work was supported by grants from the National Natural Science Foundation of China (81030012, 30890043, 30971434, 30871194, 30821001 to W.Z., and 30700376, 30971085 to Y.L.), the Major National Basic Research Program of China (2010CB912504 to W.Z.), the Program for New Century Excellent Talents in University to Y.L., the Beijing Natural Science Foundation (7112080 to Y.L.).
The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine-threonine protein kinase, belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family, which contains a lipid kinase-like doma...
Supported by the Key Laboratory of Experimental Marine Biology,Academia Sinica,Qingdao,China;the National High Technology Research and Development Program of China(863 Program)(No.2006AA10AA402);the National Basic Research Program of China(973Program)(Nos.2004CB117402,2010CB126304);the National Natural Science Foundation of China(No.30871929)
MyoD, Myf5, and myogenin are myogenic regulatory factors that play important roles during myogenesis. It is thought that MyoD and Myf5 are required for myogenic determination, while myogenin is important for terminal ...
Supported by the National Natural Science Foundation of China (Grant Nos. 30270693 and 30570967);the Ministry of Science and Technology of China (Grant No. 2007CB815800)
Myocyte enhancer factor 2 proteins are members of MADS family of transcription factors, which can control the expression of muscle-specific genes in vertebrates. However, not all Mef2 genes are es-sential for muscle d...