Ocular tuberculosis(OTB)is a chronic eye infection caused by Mycobacterium tuberculosis.Some cases of myelitis are associated with Epstein-Barr virus(EBV),with 1-5%of EBV infections leading to neurologic complications...
We appreciate Prince Sattam bin Abdulaziz University for funding this project(PSAU/2023/R/1444).
Mycobacterium tuberculosis(Mtb)is responsible for the spread of tuberculosis(TB).The current study employed virtual screening of 2569 natural compounds against the DNA-directed RNA polymerase(RNAP)of Mtb to identify t...
Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health proble...
the Animal Biosafety Level 3 Laboratory(ABSL-III)of the Wuhan University School of Medicine(NO.18021B);the Second Military Medical University of Shanghai(No.18002)for their help with the M.tb infection experiment;This project was supported by grants from the National Grand Program on Key Infectious Disease of China(2017ZX10201301-006 and 2012ZX10003002-015);the National Key R&D Program of China(2018YFA0507603);the National Natural Science Foundation of China(91740120,22077097 and 21721005);the National Outstanding Youth Foundation of China(81025008);Hubei Province’s Outstanding Medical Academic Leader Program(523-276003);Hubei Province Key R&D Program(2020BCB020);Research and Innovation Team Project of Hubei Provincial Health Commission(WJ2021C002);the Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University(TFJC 2018002);the Fundamental Research Funds for the Central Universities.
Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of intracellular pathogens. However, the role andmechanism of the important lncRNAs in Mycobacterium tuberculosis (M.tb) infection remain largely ...
Introduction: Mycobacteria pulmonary diseases are chronic illnesses with various impacts on patients’ health status, and wellbeing. These diseases currently represent a global health issue due to increasing burdens a...
Key R&D and Promotion Projects of Henan Province,grant number 192102310156,the National Natural Science Foundation of China,Grant No.81601740;the Applied Basic Research Program of Science&Technology Department of Sichuan Province,Grant No.2018JY0108;the National Undergraduate Training Program for Innovation and Entrepreneurship(X2017013,X2019070,202010475006).
The rapid emergence of multidrug-resistant and extensively drug-resistant Tuberculosis retrieved intense interest in phage-based therapy.This old approach,which was abandoned in the west in the 1940s but is generating...
BACKGROUND Medical therapy for strictures is limited and first-line treatment consists of endoscopic balloon dilatation,strictureplasty or surgical resection.Mycobacterium tuberculosis,Helicobacter pylori and Streptoc...
Background: Tuberculosis (TB) is an infectious disease and it is a public health concern due to the endemic nature of the disease. Nigeria’s health systems still rely heavily on out-dated tuberculosi...
Inhibition of Mycobacterium tuberculosis(Mtb)cell wall assembly is an established strategy for anti-TB chemotherapy.Arabinosyltransferase EmbB,which catalyzes the transfer of arabinose from the donor decaprenyl-phosph...
A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as wel...