EXCITABILITY

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Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal
《Neuroscience Bulletin》2023年第5期731-744,共14页Xiao-Wei Li Yi Ren Dong-Qing Shi Lei Qi Fang Xu Yanyang Xiao Pak-Ming Lau Guo-Qiang Bi 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。
Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...
关键词：ACETYLCHOLINE Neuronal network REVERBERATION Synaptic current EXCITABILITY 
Inhibition of intracellular proton-sensitive Ca^(2+)-permeable TRPV3 channels protects against ischemic brain injury被引量：5
《Acta Pharmaceutica Sinica B》2022年第5期2330-2347,共18页Xiaoling Chen Jingliang Zhang KeWei Wang 
supported by grants awarded to KeWei Wang from National Natural Science Foundation of China (81903734 and81973299);the Ministry of Science and Technology of China(2018ZX09711001-004-006)。
Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-D-aspartate(NMDA) receptors have failed ...
关键词：TRPV3 Ca^(2+)influx ACIDOSIS Cerebral ischemia/reperfusion injury EXCITOTOXICITY Neural excitability Forsythoside B tMACO OGD TRP 
Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices被引量：3
《Acta Pharmacologica Sinica》2017年第9期1248-1256,共9页Hui PENG Xi-ling BIAN Fu-cui MA Ke-Wei WANG 
The prefrontal cortex （PFC） critical for higher cognition is implicated in neuropsychiatric diseases, such as Alzheimer＇s disease, depression and schizophrenia. The voltage-activated Kv7/KCNQ/M-channel or M-current...
关键词：Kv7 KCNQ M-CURRENT prefrontal cortex pyramidal neurons EXCITABILITY MEPSC RETIGABINE XE991 neuropsychiatric diseases 
Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region in rats被引量：1
《Neural Regeneration Research》2014年第11期1138-1144,共7页Yang Wang Zhouyan Feng Jing Wang Xiaojing Zheng 
supported by Major State Basic Research Development Program of China(973 Program),No.2011CB504400
The hippocampal region of the brain is important for encoding environment inputs and memory formation. However, the underlying mechanisms are unclear. To investigate the behavior of indi-vidual neurons in response to ...
关键词：nerve regeneration somatosensory stimulation tail clamping hippocampal CA1 region local field potential unit spike population spike EXCITABILITY 973 Program neural regeneration 
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons： a modeling study被引量：1
《Acta Pharmacologica Sinica》2014年第6期738-751,共14页Shang-lin ZHOU Hong-yuan CHU Guo-zhang JIN Jian-min CUI Xue-chu ZHEN 
Acknowledgements This work was financially supported by grants from the National Natural Science Foundation of China （81130023, 31373382, and 31271143） and the National Basic Research Plan （973） of the Ministry of Science and Technology of China （2011CB5C4403）. We are also grateful for support from the Priority Academic Program Development of Jiangsu Higher Education Institutes （PAPD）.
Aim： 3-Methyl-6-chloro-7,8-hydroxy-1-（3-methylphenyl）-2,3,4,5-tetrahydro-1H-3-benzazepine （SKF83959） have been shown to affect several types of voltage-dependent channels in hippocampal pyramidal neurons. The ai...
关键词：SKF83959 HIPPOCAMPUS pyramidal neuron neuronal modeling EXCITABILITY Na＋ channel EPSP temporal summation 
Progress in neural plasticity被引量：22
《Science China(Life Sciences)》2010年第3期322-329,共8页POO Mu-Ming 
supported by the National Basic Research Program of China (Grant No 2006CB806600);the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No KSCX2-YW-R-29)
One of the properties of the nervous system is the use-dependent plasticity of neural circuits.The structure and function of neural circuits are susceptible to changes induced by prior neuronal activity,as reflected b...
关键词：long-term PLASTICITY SYNAPTIC transmission intrinsic EXCITABILITY DENDRITIC integration neuron-glia signaling neurologi-cal disease 
δ-opioid Receptor Induced Inhibition of Sodium Channel Function
《Journal of Acupuncture and Tuina Science》2008年第5期276-278,共3页康学智 顾全保 丁光宏 晁东满 王英伟 G Balboni LH Lazarus 夏萤 
the Science Foundation of Shanghai Municipal Commission of Science and Technology(05DZ19745,06DZ19732,064319053,07DZ19722,07DZ19733);the National Basic Research Program of China(973 Program,2005CB523306);Shanghai Leading Academic Discipline Project(B112 and T0302);NIH-HD3485
Objective： To study the precise role of DOR in the regulation of sodium channels at present. Methods： With Xenopus oocytes co-expressing sodium channel subtype 2 （Nav1.2） and DOR. Results： 1） Nav1.2 expression i...
关键词：δ-opioid Receptors Na^＋ Channels Na^＋ Currents UFP-512 Xenopus Oocytes EXCITABILITY 
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