TETRAHYDROPALMATINE

作品数：14被引量：52H指数：4
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相关领域：医药卫生更多>>
相关作者：胡江元金国章孟红旭姚明江尚尔鑫更多>>
相关机构：中国科学院中国中医科学院西苑医院南京中医药大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《Science China Chemistry》《Journal of Biomedical Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Network Pharmacology and Experimental Validation to Explore Mechanism of Tetrahydropalmatine on Acute Myocardial Ischemia被引量：1
《Chinese Journal of Integrative Medicine》2023年第12期1087-1098,共12页LIN Po-li CAO Jun-ling REN Ping CHEN Jia-li CAO Bo-ya HE Ping ZHENG Chang-hui LI Qi-wen WANG Wei ZHANG Jian 
Supported by the National Natural Science Foundation of China (No.82004095);the Fundamental Research Funds for the Central Universities (No.2021-JYB-XJSJJ031)。
Objective:To explore the potential molecular mechanism of tetrahydropalmatine(THP)on acute myocardial ischemia(AMI).Methods:First,the target genes of THP and AMI were collected from SymMap Database,Traditional Chinese...
关键词：TETRAHYDROPALMATINE acute myocardial infarction INFLAMMATION energy metabolism HORMONE 
Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells
《Acta Pharmacologica Sinica》2022年第4期889-896,共8页Yuan-bing Huang Ze-gang Ma Chao Zheng Xiao-kuang K.Ma Devin HTaylor Ming Gao Ronald J.Lukas Jie Wu 
Nicotine, a major component of tobacco, is highly addictive and acts on nicotinic acetylcholine receptors (nAChRs) to stimulate reward-associated circuits in the brain. It is well known that nAChRs play critical roles...
关键词：acetylcholine receptors α4β2-nicotinic receptor levo-tetrahydropalmatine SH-EP1 cells patch-clamp recording nicotine addiction 
Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells被引量：1
《Chinese Medical Journal》2022年第5期628-630,共3页Yuanyuan Xuan Shiyun Chen Xin Ding Lexun Wang Shengwen Li Guizhi Yang Tian Lan 
National Natural Science Foundation of China (No. 81870420)。
To the Editor: Liver fibrosis was characterized by the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition. The pathogenesis of liver fibrosis involved many aspects. Studies have found that...
关键词：HEPATIC reticulum protective 
L-Tetrahydropalamatine Inhibits Tumor Necrosis Factor-α-Induced Monocyte-Endothelial Cell Adhesion through Downregulation of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Involving Suppression of Nuclear Factor-κ B Signaling Pat被引量：3
《Chinese Journal of Integrative Medicine》2015年第5期361-368,共8页杨彬睿 于楠 邓艳辉 许贝文 杨斌 刘光宇 丛伟红 李铭源 
Supported by the grants from the Science and Technology Development Fund,Macao SAR(No.078/2005/A2);the Science and Technology Plan of Beijing(No.Z141100002214011)
Objective： TO investigate whether I-tetrahydropalmatine （I-THP）, an alkaloid mainly present in Corydalis family, could ameliorate early vascular inflammatory responses in atheroscleroUc processes. Methods： Fluores...
关键词：I-tetrahydropalmatine ATHEROSCLEROSIS cell adhesion molecules tumor necrosis factor-α nuclearfactor- κ B 
Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice被引量：2
《Neuroscience Bulletin》2012年第3期222-232,共11页Yan-Jiong Chen Yan-Ling Liu Qing Zhong Yan-Fang Yu Hong-Liang Su Haroldo A.Toque Yong-Hui Dang Feng Chen Ming Xu Teng Chen 
supported by grants from the Ministry of Science and Technology of China (2009 DFA 31080);the National Natural Science Foundation of China (30973365)
Objective The purpose of this study was to investigate the effect of methamphetamine （MA） on spatial learning and memory and the role of tetrahydropalmatine （THP） in MA-induced changes in these phenomena in mice. ...
关键词：methamphetamine tetrahydropalmatine Morris water maze ERK prefrontal cortex hippocampus drug addiction 
Medication of/-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users： a pilot study被引量：17
《Acta Pharmacologica Sinica》2008年第7期781-788,共8页Zheng YANG Yong-cong SHAO Shi-jiang LI Jian-lin QI Mei-jie ZHANG Wei HAO Guo-zhang JIN 
Aim： Drug addiction is a chronic brain disease with constant relapse requiring long-term treatment. New pharmacological strategies focus on the development of an effective antirelapse drug. This study examines the ef...
关键词：heroin addiction levo-tetrahydropalmatine abstinence rate RELAPSE 
Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of （-）-enantiomer and the racemate
《第二军医大学学报》2006年第3期275-275,共1页
Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of （-）-enantiomer and the racemate被引量：3
《第二军医大学学报》2005年第10期1156-1156,共1页Hong Z Fan G Chai Y Yin X Wu Y 
关键词：药物代谢动力学 外消旋酸盐 对映体 药物分析 
Effects of I-tetrahydropalmatine on locomotor sensitization to oxycodone in mice被引量：9
《Acta Pharmacologica Sinica》2005年第5期533-538,共6页Yan-liLIU Jian-huiLIANG Ling-diYAN Rui-binSU Chun-fuWU Ze-huiGONG 
Aim:Recent studies have shown that 1-tetrahydropalmatine(l-THP),an active component of Corydolis yanhusuo,can inhibit the development of the condi- tional place preference induced by opioid receptor agonists,but the e...
关键词：L-TETRAHYDROPALMATINE OXYCODONE locomotor sensitization 
Arcuate nucleus of hypothalamus involved in analgesic action of l-THP被引量：2
《Acta Pharmacologica Sinica》2000年第5期57-62,共6页胡江元 金国章 
Supported by the National Natural Science Foundation of China, № 39770853 and 39670829.
AIM: To study the role of the arcuate nucleus of hy-pothalamus in analgesic action of l-tetrahydropalmatine (l-THP). METHODS: The horseradish peroxidase (HRP) retrograde tracing, HRP retrograde tracing combined with i...
关键词：TETRAHYDROPALMATINE horseradish perox-idase arcuate nucleus PAG corpus striatum nucleus accumbens analgesia NALOXONE ENDORPHINS 
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