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Background:Hemodynamic changes have been observed in patients with Graves'disease.The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVi)in patients with thyroid-assoc...
Pyroptosis, also known as cell inflammatory necrosis, is a new way of programmed cell death discovered and confirmed in recent years, which is characterized by dependence on inflammatory caspase and the release of a l...
Background:Hemodynamic changes have been observed in patients with Graves’disease.The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVI)in patients with thyroidassoc...
Objective: To compare the values of exophthalmos measured by computed tomography (CT) and Hertel exophthalmometry (HE) in patients with thyroid-associated ophthalmopathy (TAO). Material and Methods: One hundred and se...
This work was supported by grants from the National Natural Science Foundation of China(grant nos.81770943 and 81873681);the Beijing Municipal Science and Technology Commission(Capital Char-acteristic Clinic Applied Research Project,Z161100000516037).
Purpose:To investigate the role of N6-methyladenosine(m^(6)A)RNA modification in the pathogenesis of Graves'ophthalmopathy(GO).Methods:Surgically excised extraocular muscles from 7 patients with GO and 5 subjects with...
Supported by the National Natural Science Foundation of China (No.81670885);the Science and Technology Program of Guangdong Province, China (No.2013B020400003);the Science and Technology Program of Guangzhou, China (No.15570001)
AIM: To report the effects of intravenous high-dose glucocorticoids(iv GC) and orbital decompression(OD) surgery for treatment of sight-threatening thyroid-associated ophthalmopathy(TAO).METHODS: A retrospective revie...
Background: Graves’ ophthalmopathy (GO) is the most frequent extrathyroidal manifestation of Graves’ disease (GD). The effect of intravenous methylprednisolone on the signs and symptoms of GO has not been evaluated ...
Supported by National Natural Science Foundation of China(No.81170874)
AIM: To evaluate the benefit and harms of high-dose intravenous glucocorticoids(IVGC) as first-line treatment for Graves’ ophthalmopathy(GO).METHODS: A systematic review and Meta-analysis of randomized clinical trial...
Supported by National Natural Science Foundation of China(No.81200719);China Postdoctoral Science Foundation(No.2013M543579; No.2014T71013);Key Specialized Projects in Nanjing(No.SZDZK2016008)
Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TA...
supported by National Natural Sciences Foundation of China(No.81501552,and No.81401388)
The clinical application of orbital magnetic resonance(MR) T2-mapping imaging in detecting the disease activity of Graves' ophthalmopathy(GO), and the predictive values of therapy response to intravenous glucocor...