BACKGROUND Diazoxide is the sole approved drug for congenital hyperinsulinism;however,diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse e...
Natural Science Foundation of Gansu Provincial Science and Technology Department(Basic Research Program),No.23JRRA1385.
BACKGROUND Uterine fibroids are common benign gynecological conditions.Patients who experience excessive menstruation,anemia,and pressure symptoms should be administered medication,and severe cases require a total hys...
The study was funded by National Key Research and Development Program of China(2016YFC1305304);Beijing Children's Hospital Young Investigator Program(No.BCHYIPA-2016-06);Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support(No.ZYLX201821).
Importance: Octreotide is an off-label medicine for congenital hyperinsulinism (CHI), but is currently widely used for treatment of patients with CHI. Thus far, variable efficacy and adverse effects have been reported...
supported by the Technology Development Plan of Linyi City, No. 201113002
Diazoxide, an activator of mitochondrial ATP-sensitive potassium channels, can protect neurons and astrocytes against oxidative stress and apoptosis. In this study, we established a cellular mode of epilepsy by cultur...
Mitochondrial K+-ATP (mito-KATP) channels play an important role in cellular function and survival following ischemic stress. The present results revealed that intervention with diazoxide, a mito-KATP channel opene...
This study was supported by a grant from Specialized Research Fund for Doctoral Program of Higher Education, Ministry of Education of China (No. 20030023028).
Background Cerebral ischemia-reperfusion/hypoxia-reoxygenation insult triggers lots of pathophysiological and biochemical events that separately affect the evolution of cerebral damage. Accordingly, all known effectiv...
Supported by the National Natural Science Foundation of China (No. 30200089 and No. 30500211)
Objectives To analyze and identify differentially expressed phosphoproteins associated with mitochondrial KATP channel opening. Methods: Adult rat ventricular myocytes were isolated, cultured, and identified, and pre...
AIM: To study the effects of indomethacin on the isolated transverse and longitudinal rat gastric fundus strips.METHODS: The strips were suspended in an organ bath containing oxygenated Krebs solution, and contractile...
To assess whether diazoxide could enhance myocardial protection during hypothermic preservation of the rat heart.Methods Langendorff model of isolated rat heart was used.After 30 minutes stabilization,the hearts were ...