SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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  • 期刊=Neural Regeneration Researchx
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Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma被引量：1
《Neural Regeneration Research》2023年第4期840-848,共9页Devaraj Basavarajappa Vivek Gupta Nitin Chitranshi Roshana Vander Wall Rashi Rajput Kanishka Pushpitha Samridhi Sharma Mehdi Mirzaei Alexander Klistorner Stuart L.Graham 
This investigator-initiated study grant(to SLG)was funded by Novartis,Australia;the funding support from the National Health and Medical Research Council(NHMRC)of Australia,Perpetual Hilcrest,Ophthalmic Research Institute of Australia(ORIA);Macquarie University,NSW,Australia。
Sphingosine-1-phosphate receptor(S1PR)signaling regulates diverse pathophysiological processes in the central nervous system.The role of S1PR signaling in neurodegenerative conditions is still largely unidentified.Sip...
关键词：GLAUCOMA intraocular pressure NEURODEGENERATION NEUROPROTECTION optic nerve injury retinal ganglion cells siponimod sphingosine-1-phosphate 
Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2023年第4期869-874,共6页Xiao-Yu Zhu Ting-Ting Ma Yang Li Ming-Qi Zhang Liang Zhao Jia Liang Lian-Qiu Min 
supported by grants from the National Natural Science Foundation of China,No.81971231(to JL);Liaoning Revitalization Talents Program,No.XLYC1907178(to JL)。
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms.Fingolimod(FTY-720)i...
关键词：astrocyte blood-brain barrier CLAUDIN-5 FTY-720 INTERLEUKIN-17A ischemic stroke neural protection neurovascular unit OCCLUDIN sphingosine-1-phosphate receptor 1 
The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis被引量：2
《Neural Regeneration Research》2019年第11期1950-1960,共11页Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth 
supported by the Novartis Institutes of Biomedical Research,Basel,Switzerland(to SGM)
Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stag...
关键词：multiple SCLEROSIS FOCAL experimental autoimmune ENCEPHALOMYELITIS CORTICAL grey MATTER white MATTER BAF312 neuroaxonal damage neuroprotection 
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