SPHINGOSINE

作品数：80被引量：236H指数：8
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相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Sphingolipid metabolism and drug resistance in ovarian cancer被引量：3
《Cancer Drug Resistance》2018年第3期181-197,共17页Kelly M.Kreitzburg Robert C.A.Mvan Waardenburg Karina J.Yoon 
Waardenburg RCAM is supported by DoD OCRP pilot grant W81XWH-15-1-0198;This work was supported by Faculty Development Grant from University of Alabama at Birmingham,Comprehensive Cancer Center(P30 CA013148).
Despite progress in understanding molecular aberrations that contribute to the development and progression of ovarian cancer,virtually all patients succumb to drug resistant disease at relapse.Emerging data implicate ...
关键词：Ovarian cancer DRUG-RESISTANCE CERAMIDE sphingosine-1-phosphate sphingolipid metabolism 
Targeting sphingosine-1-phosphate signaling for cancer therapy被引量：7
《Science China(Life Sciences)》2017年第6期585-600,共16页Zuoquan Xie Hong Liu Meiyu Geng 
financial support from the National Natural Science Foundation of China(91229204);the Major Project of the Chinese National Programs for Fundamental Research and Development(2015CB910304)
Sphingosine-1-phosphate(S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival,cell proliferation, cell migration, angiogenesis and many other cellular processes. S1 P ...
关键词：sphingosine-1-phosphate sphingosine ceramide cancer inflammation immunity 
Sphingolipids in cardiovascular and cerebrovascular systems:Pathological implications and potential therapeutic targets
《World Journal of Cardiology》2013年第4期75-86,共12页Masahito Kawabori Rachid Kacimi Joel S Karliner Midori A Yenari 
Supported by Grants from the National Institutes of Health (NS40516,to Yenari MA);the Veteran's Merit Award(Yenari MA);the Uehara Foundation(2013 Research Fellowship,to Kawabori M);the National Heart,Lung,and Blood Institute/NHLBI(1P01 HL 68738 and R01 HL 090606 to Karliner JS);Grants to Yenari MA and Karliner JS were administered by the Northern California Institute for Research and Education;supported by resources of the Veterans Affairs Medical Center, San Francisco,California
The sphingolipid metabolites ceramide,sphingosine,and sphingosine-1-phosphate(S1P) and its enzyme sphingosine kinase(SphK) play an important role in the regulation of cell proliferation,survival,inflammation,and cell ...
关键词：SPHINGOLIPIDS Sphingosine-1-phosphate SPHINGOSINE KINASE CERAMIDE KINASE 
Roles of sphingosine 1-phosphate on tumorigenesis被引量：5
《World Journal of Biological Chemistry》2011年第2期25-34,共10页Hsinyu Lee 
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities.It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosi...
关键词：SPHINGOSINE 1-phosphate SPHINGOSINE KINASE CERAMIDE ANGIOGENESIS Autophagy TUMORIGENESIS 
Role of sphingosine kinase localization in sphingolipid signaling
《World Journal of Biological Chemistry》2010年第12期362-368,共7页Binks W Wattenberg 
Supported by The James Graham Brown Cancer Center and NIH, No. CA111987
The sphingosine kinases, SK1 and SK2, produce the potent signaling lipid sphingosine-1-phosphate (S1P). These enzymes have garnered increasing interest for their roles in tumorigenesis, inflammation, vascular diseases...
关键词：SPHINGOLIPID LIPID signaling CERAMIDE Sphingosine-1-phosphate SPHINGOSINE 
A New Ceramide from the Soft Coral Cladiella humesi Verseveldt被引量：4
《Chinese Chemical Letters》2000年第9期783-784,共2页Ming Yan WANG Yi LUO Jing Yu SU Department of Chemistry, Zhongshan University, Guangzhou 5 10275 
This work was supported by the National Science Foundation of China !(960012).
A new ceramide, humesamide, was isolated from the soft coral Cladiella humesi Verseveldt, which was collected from Linshui County of Hainan Province. Its structure was established by spectroscopic analysis and chemica...
关键词：Cladiella humesi soft coral CERAMIDE SPHINGOSINE 
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