SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling被引量：3
《Acta Pharmacologica Sinica》2024年第1期98-111,共14页Shuang Yang Hou-wei Li Jia-ying Tian Zheng-kai Wang Yi Chen Ting-ting Zhan Chun-yue Ma Min Feng Shifeng Cao Yu Zhao Xue Li Jing Ren Qian Liu Lu-ying Jin Zhi-qi Wang Wen-yu Jiang Yi-xiu Zhao Yan Zhang Xue Liu 
supported by National Natural Science Foundation of China(82170431,81870259,81903608).
Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell(VSMC)dedifferentiation.Myeloid-derived growth factor(MYDGF),secreted from bone marrow-derived...
关键词：carotid artery balloon injury neointimal formation VSMC dedifferentiation MYDGF Sphingosine-1-phosphate receptor 2 
Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury被引量：8
《Acta Pharmaceutica Sinica B》2022年第4期1885-1898,共14页Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun 
supported by the National Natural Science Foundation of China (Nos.81973301, 82003732 and 81773701);the Medical Research Project of Jiangsu Commission of Health (No.ZDA2020006, China);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.18KJA310004);the Major Project of Nanjing Medical University (No.NMUD2018008, China);the Postgraduate Research and Practice Innovation Program of Jiangsu Province (Nos.KYCX19_1121 and KYCX20_1417, China);Priority Academic Program Development of Jiangsu Higer Education Institutions (China)
The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used compu...
关键词：S1P TREM2 MICROGLIA PHAGOCYTOSIS Stroke APOE LRP1B Apoptotic neurons 
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation被引量：2
《Acta Pharmacologica Sinica》2021年第3期460-469,共10页Yu-hang Zhang Shu-xiang Cui Sheng-biao Wan Shu-hua Wu Xian-jun Qu 
supported by the National Natural Science Foundation of China(91629303/81673449/81872884/81973350);the Beijing Natural Science Foundation and Scientific Research Program of Municipal Commission of Education(KZ201710025020/KZ201810025033)。
Sphingosine-1-phosphate(S1P),the backbone of most sphingolipids,activating S1P receptors(S1PRs)and the downstream G protein signaling has been implicated in chemoresistance.In this study we investigated the role of S1...
关键词：colorectal cancer 5-FU resistance sphingosine-1-phosphate(SI P) S1PR2 internalization endoplasmic reticulum calcium([Ca^(2+)]ER) uracil generation JTE-013 
Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice被引量：2
《Acta Pharmacologica Sinica》2020年第11期1487-1496,共10页Soo-Jin Park Dong-Soon Im 
supported by the Basic Science Research Program of the Korean National Research Foundation funded by the Korean Ministry of Education,Science and Technology(NRF-2019R1A2C1005523).
Sphingosine-1-phosphate(S1P)and its receptors have been implicated in functions of Langerhans cells and atopic dermatitis.In thisstudy,we investigated the roles of S1P receptor type 2(S1P2)in a mouse model of atopic d...
关键词：atopic dermatitis sphingosine-1-phosphate sphingosine-1-phosphate receptor type 2(S1P2) S1pr2 gene-deficient mice bone marrow-derived dendritic cell cytokines 
Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates
《Acta Pharmaceutica Sinica B》2020年第6期1134-1142,共9页Qiong Xiao Minwan Hu Si Chen Yifan Tang Zeyu Shi Jing Jin Jinping Hu Ping Xie Dali Yin 
financially supported by the Drug Innovation Major Project(No.2018ZX09711001-005-012,China);National Key R&D Program of China(No.2018YFC1706403);CAMS Innovation Fund for Medical Sciences(No.2016-I2M-2-002,China);Disciplines construction project(No.201920200802,China)
FTY720 and IMMH002,prodrugs for sphingosine-1-phosphate receptor 1(S1P1)agonists,show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats.In this study,FTY720 or IMMH002 analogues(...
关键词：S1P1 agonist PRODRUG Catalytic amination Phosphate formation rate LYMPHOCYTE 
Pharmacokinetics of H002, a novel S1PR_1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry被引量：5
《Acta Pharmaceutica Sinica B》2016年第6期576-583,共8页Jiaqi Mi Manman Zhao Shu Yang Shuang Yang Jing Jin Xiaojian Wang Qiong Xiao Jinping Hu Yan Li 
supported by the National Science and Technology Major Project of China(Nos.2012ZX09301002-001-007 and2012ZX09301002-006);National Natural Science Foundation of China(NSFC,Nos.81202545,81302847 and 81473096)
A rapid and sensitive liquid chromatography–tandem mass spectrometry(LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated...
关键词：S1P receptor S1PR1 modulator Sphingosine-1-phosphate S1P analogue Metabolite LC–MS/MS PHARMACOKINETICS Periphery blood lymphocyte 
An efficient method for preparing the sphingosine-1-phosphate receptor agonist, KRP203-phosphate
《Chinese Chemical Letters》2013年第9期817-820,共4页Xiao-Jian Wang Jian-Guo Qi Gang Li Yu-Lin Tian Da-Li Yin 
financially supported by National Natural Science Foundation of China(No.81102322)
An efficient method for mono-phosphorylation of 2 （KRP203） using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P （KRP203-P） was developed. We applied the present method to the synthesis of KRP20...
关键词：Mono-phosphorylation TMSI KRP203-P 
Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates
《Acta Pharmacologica Sinica》2008年第10期1227-1232,共6页Santosh J SACKET Dong-soon IM 
Aim： To characterize sphingosine methyltransferase in rat tissues. Methods： By using S-adenosyl-L-（methyl-3^H） methionine, enzymatic activity was measured in the rat liver and kidney homogenates. Results： The opt...
关键词：SPHINGOSINE O-METHYLATION METHYLTRANSFERASE sphingosine kinase LIPID SPHINGOLIPID 
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