O-METHYLATION

作品数：16被引量：15H指数：2
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NOP56 promotes hepatocellular carcinoma progression through 2'-O-methylation
《Genes & Diseases》2025年第2期33-36,共4页Shuxin Yang Juan Liu Shengxin Luo Wentao Wang Jingxiang Xu 
funded by the High-level Talent Research Funds of Gannan Medical University (No.QD202122).
Hepatocellular carcinoma(HCC)is a common malignant tumor and one of the leading causes of cancer-related deaths,with the fourth-highest incidence rate and the second-highest mortality rate in China.1 Currently,HCC is ...
关键词：MORTALITY CHEMOTHERAPY surgery 
SNORD3B-2 promotes endometrial carcinoma progression by 2'-O-methylation modification of PLK1 and regulating RAB17 alternative splice
《Genes & Diseases》2025年第2期90-93,共4页Xi Chen Yuping Du Bumin Xie Qianhui Li Yumeng Ji Yang Han Xiujie Sheng Shuo Chen Yang Zhao 
supported by the National Natural Science Foundation of China (No.82072854 to Yang Zhao,82272985 to Shuo Chen);the Project for Key Medicine Discipline Construction of Guangzhou Municipality,Guangdong,China (No.2021-2023-17);the Science and Technology Projects in Guangzhou,Guangdong,China (No.202201020093 to Yang Zhao).
Endometrial cancer(EC)is one of the most common gynecological malignant tumors.Further investigation of the potential molecular mechanism of EC is important.Small nucleolar RNA(snoRNA)is a type of non-coding RNA,with ...
关键词：PLK1 PI3K ENDOMETRIAL 
Complicated target recognition by archaeal box C/D guide RNAs被引量：2
《Science China(Life Sciences)》2024年第4期631-644,共14页Jiayin Wang Songlin Wu Keqiong Ye 
supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDB0570000,XDB37010201);the Basic Research Program Based on Major Scientific Infrastructures of Chinese Academy of Sciences(JZHKYPT-2021-05);the National Natural Science Foundation of China(91940302,91540201,31430024,31325007);the National Key Research and Development Program of China(2017YFA0504600)。
Box C/D RNAs guide the site-specific formation of 2′-O-methylated nucleotides(Nm)of RNAs in eukaryotes and archaea.Although C/D RNAs have been profiled in several archaea,their targets have not been experimentally de...
关键词：C/D RNA 2′-O-methylation ARCHAEA guide RNA RNA modification 
A twist in the tale:global insights into archaeal box C/D RNA-guided 2′-O-methylation
《Science China(Life Sciences)》2024年第4期849-850,共2页Bin Li Jianhua Yang 
supported by the National Key Research and Development Program of China(2019YFA0802202,2022YFA1303300);the National Natural Science Foundation of China(32225011,31971228,31370791,91440110,32370588);Youth Science and Technology Innovation Talent of Guangdong TeZhi Plan(2019TQ05Y181)。
The 2′-O-methylation of RNA stands as a dynamic and multifaceted modification,wielding significant influence over the regulation of RNA function,stability,and interactions within the cellular context(Sun et al.,2023)...
关键词：TWIST INSIGHT 
Nm-Mut-seq:a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation被引量：1
《Cell Research》2023年第9期727-730,共4页Li Chen Li-Sheng Zhang Chang Ye Huiqing Zhou Bei Liu Boyang Gao Zixin Deng Changming Zhao Chuan He Bryan C.Dickinson 
This work was supported by the National Human Genome Research Institute(RM1 HG008935 to C.H.and B.C.D.);the National Institute of Mental Health(R01 MH122142 to B.C.D.)of the National Institutes of Health(NIH);the University of Chicago Medicine Comprehensive Cancer Center(P30 CA14599)and the international postdoctoral exchange fellowship program(20190048)(L.C.);The evolved RT biochemistry work was partially supported by the National Key R&D Program of China(2018YFA0903200 to C.Z.).C.H.is an investigator at Howard Hughes Medical Institute.We thank Dr.Qing Dai for his help and suggestions on library construction.
Dear Editor,2'-O-methylation(Nm)(Fig.1a)is a prevalent post-transcriptional RNA modification present in many cellular RNAs and plays critical roles in modulating both physical properties and functions of eukaryotic RN...
关键词：mapping methods BASE 
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method被引量：4
《Science China(Life Sciences)》2023年第4期800-818,共19页Ping Zhang Junhong Huang Wujian Zheng Lifan Chen Shurong Liu Anrui Liu Jiayi Ye Jie Zhou Zhirong Chen Qiaojuan Huang Shun Liu Keren Zhou Lianghu Qu Bin Li Jianhua Yang 
supported by the National Key R&D Program of China(2019YFA0802202);the National Natural Science Foundation of China(91940304,31971228,31900903,31970604,32100467,32225011);the Youth Science and Technology Innovation Talent of Guangdong Te Zhi Plan(2019TQ05Y181)。
2′-O-methylation(Nm)is one of the most abundant RNA epigenetic modifications and plays a vital role in the post-transcriptional regulation of gene expression.Current Nm mapping approaches are normally limited to high...
关键词：2′-O-methylation MgR exoribonuclease periodate oxidation epitranscriptome TRANSCRIPTOME 
SnoRNP is essential for thermospermine-mediated development in Arabidopsis thaliana被引量：2
《Science China(Life Sciences)》2023年第1期2-11,共10页Xilong Li Zongyun Yan Meiling Zhang Jiayin Wang Peiyong Xin Shujing Cheng Liquan Kou Xiaoting Zhang Songlin Wu Jinfang Chu Chengqi Yi Keqiong Ye Bing Wang Jiayang Li 
supported by the National Natural Science Foundation of China(31788103,32122012,32100221,91940302,31430024);the Strategic Priority Research Program of Chinese Academy of Sciences(XDA24040202);the Chinese Academy of Sciences Youth Innovation Promotion Association(2019099);the CAS Key Technology Talent Program(2017)。
Polyamines have been discovered for hundreds of years and once considered as a class of phytohormones.Polyamines play critical roles in a range of developmental processes.However,the molecular mechanisms of polyamine ...
关键词：polyamines thermospermine SNORNP pseudouridylation 2’-O-methylation Arabidopsis thaliana 
Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins被引量：2
《Synthetic and Systems Biotechnology》2022年第3期880-886,共7页Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi Hou-Wen Lin Yongjun Zhou 
support from the National Natural Science Foundation of China(Nos.32070070,31929001,and 31800031);the Innovative Research Team of High-Level Local Universities in Shanghai。
Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.The backbones of piericidins are derived fromβ,...
关键词：POLYKETIDE Pyridine Polyketide synthase(PKS) Natural product biosynthesis 
Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application被引量：2
《Blood Science》2021年第4期122-131,共10页Li-Min Lin Qi Pan Yu-Meng Sun Wen-Tao Wang 
National Natural Science Foundation of China(82000168 and 31870818)。
Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis,prognosis,and treatment of leukemia.Research has found that small nuclear RNA(snoRNA)plays an essential role in leukemia.These sma...
关键词：2'-O-methylation Biomarkers Drug resistance LEUKEMIA SNORNA Targeted therapy 
Epitranscriptomics of cancer被引量：2
《World Journal of Clinical Oncology》2018年第3期42-55,共14页Marina Tusup Thomas Kundig Steve Pascolo 
Supported by University of Zurich:"URPP:Translational Cancer research";the"MERIT"project supported by the FP7 European Union’s Research;Innovation Funding program
The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opp...
关键词：RNA modifications N6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine PSEUDOURIDINE INOSINE 
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