云南高校图书馆联盟文献共享服务平台- 双链

双链: 作品数：1528被引量：3650H指数：21; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：王永明王帅唐春然张立君郭骁才更多>>; 相关机构：中国科学院浙江大学阿尔尼拉姆医药品有限公司复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>

Spontaneous DNA damage propels tumorigenicity: 《Cell Research》2017年第6期720-721,共2页Ilio Vitale Guido Kroemer; High levels of endogenously gen- erated DNA damage drive oncogen- esis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additiona...; 关键词：DNA损伤损伤机制双链断裂性基因侵袭性恶性细胞

An evolving function of DNA-containing exosomes in chemotherapy-induced immune response被引量：6: 《Cell Research》2017年第6期722-723,共2页Paul Kurywchak Raghu Kalluri; Chemotherapy is a predominant strategy to treat cancer and is of- ten associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et aL recently expl...; 关键词：DNA传感器免疫反应化疗进化双链DNA 免疫细胞副作用大肠癌

Mex3B： a coreceptor to present dsRNA to TLR3被引量：1: 《Cell Research》2016年第4期391-392,共2页Shu Zhu, Geng Wang, Xuqiu Lei Richard A Flavell; Toll-Like Receptors （TLRs） play critical roles in the early innate im- mune response to invading pathogens by sensing microorganisms; a num- ber of accessory molecules have been shown to assist microbial recognition...; 关键词：DSRNA Toll样受体微生物入侵双链RNA 通过检测水解处理病原体 TLR

H1 provides the missing link: 《Cell Research》2016年第1期5-6,共2页Michael SY Huen Junjie Chen; Adding to the Histone Code at DNA double-strand breaks, Mailand and colleagues now uncover non- degradative ubiquitin marks on linker histone HI as key signaling intermediates in the DNA damage signal transduction cas...; 关键词：DNA双链断裂组蛋白密码信号转导通路 DNA损伤信号分子泛素

DNA damage and repair regulate neuronal gene expression: 《Cell Research》2015年第9期993-994,共2页Yijing Su; Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity tr...; 关键词：基因表达神经元修复损伤 CELL 双链断裂可塑性记忆

Double-stranded DNA in exosomes： a novel biomarker in cancer detection被引量：108: 《Cell Research》2014年第6期766-769,共4页Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden; Exosomes, small membrane vesicles （30-100 nm） of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally transferred to recipient cells [1]. Exosomes bear a specific ...; 关键词：生物标记物双链DNA 癌症检测 microRNA SSDNA 单链DNA 细胞类型生物分子

diRNA-Ago2-RAD51 complexes at double-strand break sites被引量：3: 《Cell Research》2014年第5期511-512,共2页Soichiro Yamanaka Haruhiko Siomi; The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully elucidated. Now, Gao et al. reveal that diRNA-Ago2 complexes recruit RAD51 to the break sites.; 关键词：双链断裂 DNA损伤网站 DNA修复应答信号 GAO 复合物

Efficient genome editing in plants using a CRISPR/Cas system被引量：228: 《Cell Research》2013年第10期1229-1232,共4页Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu; Dear Editor, In the past few years, the development of sequence- specific DNA nucleases has progressed rapidly and such nucleases have shown their power in generating efficient targeted mutagenesis and other genome e...; 关键词：CAS系统基因组编辑植物 DNA双链断裂 DNA结合结构域非编码RNA DNA核酸

Targeted mutagenesis in rice using CRISPR-Cas system被引量：115: 《Cell Research》2013年第10期1233-1236,共4页Jin Miao Dongshu Guo Jinzhe Zhang Qingpei Huang Genji Qin Xin Zhang Jianmin Wan Hongya Gu Li-Jia Qu; Genome editing of model organisms is essential for gene function analysis and is thus critical for human health and agricultural production. The current technolo- gies used for genome editing include ZFN （zinc-finger...; 关键词：CAS系统定向诱变模式生物基因组水稻 DNA双链断裂非同源末端连接基因功能分析重复序列

RNA-guided genome editing a la carte被引量：3: 《Cell Research》2013年第6期733-734,共2页Philippe Horvath Rodolphe Barrangou; Two recent papers in Science il lustrate how the prokaryotic CRIS PRCas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated mo...; 关键词：小分子RNA 人类基因组编辑点非同源末端连接核酸内切酶 DNA裂解双链DNA 位点特异性

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