The authors are grateful for financial support from the Beijing Natural Science Foundation(No.JQ18024);the National Natural Science Foundation of China(Nos.21822701,91953111,21672012);the Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910001001);State Key Laboratory of Natural and Biomimetic Drugs.
An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prep...
Cancer is cell fleeing from death by blocking the intrinsic and extrinsic programs of cell death. The six elements that shut down those programs are: muc-1, muc-4, muc-16, Bcl-2, MMPs and decoy R3. The nuclear factor-...