ANTI-APOPTOTIC

作品数：33被引量：92H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：严勇亮徐耀春俞飚李嫣王任小更多>>
相关机构：皖南医学院弋矶山医院哈尔滨医科大学新疆农业大学第四军医大学西京医院更多>>
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Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
《World Journal of Stem Cells》2024年第5期551-559,共9页Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf Wassim Abou-Kheir Dana Zeineddine Ola Hadadeh 
Supported by the National Council for Scientific Research in Lebanon,CNRS-L.
BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos.ESCs exhibit a unique combination of self-renewal potency,...
关键词：Mouse embryonic stem cells SELF-RENEWAL Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1 
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
《Signal Transduction and Targeted Therapy》2023年第6期3055-3069,共15页Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu 
supported by the National Natural Science Foundation of China(81730061 to J.W.,82072834 to X.C.,32100697 to L.Z.and 32200117 to P.P.);China Postdoctoral Science Foundation(2020M683177 to P.P.,2020T130046ZX to P.P.);Open Research Fund Program of the State Key Laboratory of Virology of China(2021KF003 to P.P.);Open Research Fund Program of Guangdong Provincial Key Laboratory of Virology(2022KF003 to P.P.);R&D Program of Guangzhou Laboratory(SRPG22-006 to Q.Z.)。
Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity...
关键词：APO PREVENTION promoted 
Anti-apoptotic efficacy of Qingnao Yizhi formula(清脑益智方)in hypoxia/reoxygenation primary cortical neurons through the promotion of synaptic plasticity by modulating the NogoA-Nogo receptor/Rho-Rho kinase signaling pathway被引量：5
《Journal of Traditional Chinese Medicine》2021年第1期59-67,共9页QIN Xiude LIU Yu WU Haibin WU Yanqing WANG Shuo ZHU Jinqiang 
Supported by the National Natural Science Foundation of China(Study on the Mechanism of NogoA-NgR/Rho-ROCK in Regulating the Synaptic Remodeling of VD,No.81202653);the China Postdoctoral Fund of Sciences(Study on the Mechanism of Qingnao Yizhi Formula Based on the PI3K-Akt-mTOR Signal Transduction Pathway in the Treatment of Vascular Dementia,No.20110490080);Science and Innovation Commission of Shenzhen(Mechanism Study of Hydroxysafflor Yellow A Regulating Mitochondrial Autophagy through ROS Mediated PINK1/parkin Pathway in the Treatment of Acute Cerebral Infarction,JCYJ20180302173504891);Science and Innovation Commission of Shenzhen(lncRNA Malat1 Mediates SDF1/CXCR4 Axis in Cerebral Angiogenesis after Acute Cerebral Infarction and the Intervention Mechanism of Hydroxysafflor Yellow A,JCYJ 20190812161807600)。
OBJECTIVE:To evaluate the anti-apoptotic efficacy of Qingnao Yizhi formula(清脑益智方,QNYZ)in cultured cerebral cortical neuronal cells(CNCs)and the regulation of the NogoA-Nogo receptor(NgR)/Rho-Rho kinase(ROCK)signa...
关键词：Apoptosis hypoxia nogo receptors rho-associated kinases signal transduction neuronal plasticity Qingnao Yizhi formula 
Methanolic extract of Clausena excavata promotes wound healing via antiinflammatory and anti-apoptotic activities
《Asian Pacific Journal of Tropical Biomedicine》2020年第5期232-238,共7页Shaymaa Fadhel Abbas Albaayit Abdullah Rasedee Noorlidah Abdullah Yusuf Abba 
financially supported by the University of Malaya PPP Grant no.PG059-2013A.
Objective: To investigate the anti-inflammatory properties of methanolic extract of Clausena excavata in lipopolysaccharide(LPS)-activated macrophages(J774 A.1) and the effect on skin wound in a rat model through dete...
关键词：CLAUSENA excavata leaves ANTI-INFLAMMATORY cytokines Cytotoxicity APOPTOTIC genes 
Tumour suppressor microRNAs contribute to drug resistance in malignant pleural mesothelioma by targeting anti-apoptotic pathways被引量：2
《Cancer Drug Resistance》2019年第4期1193-1206,共14页Marissa Williams Yuen Yee Cheng Monica Phimmachanh Patrick Winata Nico van Zandwijk Glen Reid 
This work was supported by a Cancer Institute New South Wales Program Grant(van Zandwijk N and Reid G)and a Sydney Catalyst PhD fellowship(Williams M).
Aim:Aberrant microRNA expression is a common event in cancer drug resistance,however its involvement in malignant pleural mesothelioma(MPM)drug resistance is largely unexplored.We aimed to investigate the contribution...
关键词：Malignant pleural mesothelioma miR-15a miR-16 MIR-34A BCL2 apoptosis 
Hyodeoxycholic acid protects the neurovascular unit against oxygen-glucose deprivation and reoxygenation-induced injury in vitro被引量：16
《Neural Regeneration Research》2019年第11期1941-1949,共9页Chang-Xiang Li Xue-Qian Wang Fa-Feng Cheng Xin Yan Juan Luo Qing-Guo Wang 
supported by the National Natural Science Foundation of China,No.81430102(to QGW)
Calculus bovis is commonly used for the treatment of stroke in traditional Chinese medicine. Hyodeoxycholic acid(HDCA) is a bioactive compound extracted from calculus bovis. When combined with cholic acid, baicalin an...
关键词：hyodeoxycholic acid oxygen glucose deprivation and REOXYGENATION blood-brain barrier permeability anti-oxidative anti-inflammatory ANTI-APOPTOTIC BRAIN-DERIVED NEUROTROPHIC FACTOR glial cell line-derived NEUROTROPHIC FACTOR ischemic stroke in vitro NEUROVASCULAR unit 
HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer
《Acta Biochimica et Biophysica Sinica》2019年第10期1064-1070,共7页Huan Fang Guangshi Du Qiuju Wu Rong Liu Ceshi Chen Jing Feng 
supported by the grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16010405 to C.C.);the National Natural Science Foundation of China(Nos.81672624 to J.F.,81830087,1602221,and 31771516 to C.C.,and 81772847 to R.L.).
Triple-negative breast cancer(TNBC)is the most aggressive subtype of breast cancer w ith poor clinical outcom es and w itho ut effective targeted therapies.Numerous studies have suggested that HDAC inhibitors(TSA/SAHA...
关键词：HDAC inhibitors POX AMPK AUTOPHAGY apoptosis TRIPLE-NEGATIVE breast cancer 
Protective effects of methane-rich saline on mice with allergic asthma by inhibiting inflammatory response, oxidative stress and apoptosis被引量：3
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2019年第10期828-837,共10页Ning ZHANG Hong-tao LU Rong-jia ZHANG Xue-jun SUN 
Project supported by the National Natural Science Foundation of China(No.81371316)
Background:Asthma is a common cause of breathing difficulty in children and adults,and is characterized by chronic airway inflammation that is poorly controlled by available treatments.This results in severe disabilit...
关键词：Asthma Methane-rich saline ANTIOXIDATION ANTI-INFLAMMATION ANTI-APOPTOTIC 
Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism被引量：11
《Neural Regeneration Research》2019年第4期597-604,共8页Yuyang Zhang Seongjin Yu Julian P.Tuazon Jea-Young Lee Sydney Corey Lauren Kvederis Chase Kingsbury Yuji Kaneko Cesar V.Borlongan 
Cesar V.Borlongan was funded by NIH R01NS071956,NIH R01 NS090962,NIH R21NS089851,NIH R21 NS094087;VA Merit Review I01 BX001407
Transplantation of human bone marrow mesenchymal stem cells(hMSCs) stands as a potent stroke therapy, but its exact mechanism remains unknown. This study investigated the anti-apoptotic mechanisms by which hMSCs exert...
关键词：apoptosis Bcl-2 antibody human MESENCHYMAL stem cells ISCHEMIA NEUROPROTECTION oxygen glucose DEPRIVATION 
Quranic Verse No. 8 of Surat Al-Jumu’ah Leads Us to Describe Cancer and Determine its True Cause (Part-II)被引量：1
《CellBio》2018年第2期13-22,共10页Mahmoud Saad Mohamed El-Khodary 
Cancer is cell fleeing from death by blocking the intrinsic and extrinsic programs of cell death. The six elements that shut down those programs are: muc-1, muc-4, muc-16, Bcl-2, MMPs and decoy R3. The nuclear factor-...
关键词：CANCER CAUSE MUC-1 Muc-4 Muc-16 Metalloprotenase Enzymes (MMPs) Bcl-2 Decoy-R3 NF-KB ANTI-APOPTOTIC Genes 
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