PARKINSONS_DISEASE

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Dopaminergic Dysfunction and Glucose Metabolism Characteristics in Parkin-Induced Early-Onset Parkinson’s Disease Compared to Genetically Undetermined Early-Onset Parkinson’s Disease被引量：1
《Phenomics》2023年第1期22-33,共12页Feng-Tao Liu Jia-Ying Lu Yi-Min Sun Ling Li Yu-Jie Yang Jue Zhao Jing-Jie Ge Ping Wu Jie-Hui Jiang Jian-Jun Wu Chuan-Tao Zuo Jian Wang 
the grants from Ministry of Science and Technology of China(No.2016YFC1306504);Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01);ZJLab,and National Nature Science Foundation of China(Nos.91949118,81771372);Chuan-Tao Zuo received the research funding from the National Natural Science Foundation of China(Nos.82021002,81971641,81671239,and 81361120393);Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01);Science and Technology Commission of Shanghai Municipality(Nos.19441903500 and 17JC1401600);Shanghai Aging and Maternal and Child Health Research Special Project(No.2020YJZX0111);Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2020CR1038B);Science and Technology Innovation 2030 Major Project(No.2022ZD0211600);Feng-Tao Liu received the grant of the National Nature Science Foundation of China(Nos.82171252,81701250).
While early-onset Parkinson’s disease(EOPD)caused by mutations in the parkin gene(PRKN)tends to have a relatively benign course compared to genetically undetermined(GU)-EOPD,the exact underlying mechanisms remain elu...
关键词：Early-onset Parkinson’s disease PARKIN Dopamine transporter ^(18)F-fluorodeoxyglucose Supplementary motor area 
Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders被引量：1
《Cell Research》2022年第6期585-588,共4页Yun Fan Qinyue Zhao Wencheng Xia Youqi Tao Wenbo Yu Mingjia Chen Yiqi Liu Jue Zhao Yan Shen Yunpeng Sun Chenfang Si Shenqing Zhang Yaoyang Zhang Wensheng Li Cong Liu Jian Wang Dan Li 
supported by the National Natural Science Foundation of China(82188101,32171236,31872716,82171421,91949118,81771372 and U1932204);the Major State Basic Research Development Program of China(2019YFE0120600);the National Health Commission of China(Pro20211231084249000238);the Science and Technology Commission of Shanghai Municipality(20XD1425000,2019SHZDZX02 and 21S31902200);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Zhangjiang Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology,the CAS project for Young Scientists in Basic research(YSBR-009);the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-005);the Science Innovation 2030-Brain Science and Brain-Inspired Intelligence Technology Major Project(2021ZD0201104)from the Ministry of Science and Technology of China.
Dear Editor,Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies including Parkinson’s disease(PD),Parkinson’s disease dementia(PDD),dementia with Lewy b...
关键词：AMYLOID diseases FIBRILLATION 
Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype被引量：8
《Neuroscience Bulletin》2021年第9期1271-1288,共18页Hao Li Shihao Wu Xia Ma Xiao Li Tianlin Cheng Zhifang Chen Jing Wu Longbao Lv Ling Li Liqi Xu Wenchao Wang Yingzhou Hu Haisong Jiang Yong Yin Zilong Qiu Xintian Hu 
This work was supported by the National Key R&D Program of China(2018YFA0801403);the Key-Area Research and Development Program of Guangdong Province(2019B030335001);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060200);the National Program for Key Basic Research Projects(973 Program:2015CB755605);the National Natural Science Foundation of China(81471312,81771387,81460352,81500983,31700897,31700910,31800901,31625013,and 91732302);the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province(2017FB109,2018FB052,2018FB053,2019FA007,and 202001AT070130);Chinese Academy of Sciences"Light of West China"Program,Shanghai Brain-Intelligence Project from Science and Technology Commission of Shanghai Municipality(16JC1420501);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Open Large Infrastructure Research of Chinese Academy of Sciences,and China Postdoctoral Science Foundation(2018M631105).
Whether direct manipulation of Parkinson’s disease(PD)risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue.Here,we used an adeno-associated virus serotype 9(AAV9)-deliver...
关键词：Parkinson’s disease MONKEY Adeno-associated virus-delivered CRISPR/Cas9 PINK1 DJ-1 Parkinsonian phenotype 
The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease被引量：26
《Translational Neurodegeneration》2016年第1期95-106,共12页Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao 
This work was supported by the National Key Basic Research Program of China[grant numbers G1999054008,2006cb500706,2011CB504104];the National Natural Science Foundation of China[grant number 81430022];the Shanghai Science and Technology Fund[grant number 10411954500].
Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and p...
关键词：Parkinson’s disease Treatment guideline optimal therapeutic options China 
Mitochondrial dysfunction in Parkinson’s disease被引量：1
《Translational Neurodegeneration》2016年第1期118-125,共8页Qingsong Hu Guanghui Wang 
This work was supported by the National Basic Research Program of China(2012CB947602);the National Natural Sciences Foundation of China(No.31300887);Natural Science Foundation of Jiangsu Province(BK20130299);Suzhou Clinical Research Center of Neurological Disease(Szzx201503);Jiangsu Provincial Special Program of Medical Science(BL2014042).
Parkinson’s disease(PD)is the second most common neurodegenerative disease,which is characterized by loss of dopaminergic(DA)neurons in the substantia nigra pars compacta and the formation of Lewy bodies and Lewy neu...
关键词：Parkinson’s disease NEURODEGENERATION Mitochondrial deficiency MPTP Mitochondrial complex I inhibitor MITOPHAGY 
Regulations in the United States for cell transplantation clinical trials in neurological diseases被引量：1
《Translational Neuroscience and Clinics》2015年第2期114-124,共11页He Zhu Yuanqing Tan Qi Gu Weifang Han Zhongwen Li Jason S. Meyer Baoyang Hu 
supported by the National Basic Research Program (973 Program) of China (No. 2012CBA01307);National Natural Science Fund funded by the National Natural Science Foundation of China (No. 31171430)
Objective: This study aimed to use a systematic approach to evaluate the current utilization, safety, and effectiveness of cell therapies for neurological diseases in human. And review the present regulations, conside...
关键词：fetal neural stem cells Parkinson’s disease TRANSPLANTATION differentiation dopamine neuron 
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target被引量：34
《Translational Neurodegeneration》2015年第1期151-159,共9页Qinqin Wang Yingjun Liu Jiawei Zhou 
by grants from the National Key Basic Research Program of China(2011CB504102);Natural Science Foundation of China(31430036,31123002,31321091).
Parkinson’s disease(PD),the second most common age-associated neurodegenerative disorder,is characterized by the loss of dopaminergic(DA)neurons and the presence ofα-synuclein-containing aggregates in the substantia...
关键词：Parkinson’s disease NEURODEGENERATION Glial cells NEUROINFLAMMATION 
Clinicogenetics of Parkinson’s disease:a drawing but not completed picture被引量：1
《Neuroimmunology and Neuroinflammation》2014年第1期115-126,共12页Chao-Dong Wang Piu Chan 
This study was supported by grants from National Natural Science Foundation of China(No.81371320);the Project for Young and Middle-Aged Talents of Fujian Health Care System,No.2013-ZQN-JC-29 to Dr.Chao-Dong Wang,and the Ministry of Science and Technology of China(2012AA02A514);the National Basic Research Development Program of China(2011CB504101)to Dr.Piu Chan.
Parkinson’s disease(PD)is a prevalent neurodegenerative disorder mainly affecting the population over the age of 60 years.The past decade has seen rapidly emerging data supporting a major importance of genetic factor...
关键词：ASSOCIATION biomarkers genetic variants Parkinson’s disease 
ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression被引量：8
《Protein & Cell》2013年第9期711-721,共11页Yuangang Zhu Chunyan Wang Mei Yu Jie Cui Liang Liu Zhiheng Xu 
the Chinese Academy of Sciences(XDA01010105);the National Natural Science Foundation of China(Grant Nos.30725007,31271156 and 31270826);National Basic Research Program(973 Program)(No.2012CB517904).
Mutations in LR RK2(Leucine rich repeat kinase 2)are a major cause of Parkinson’s disease(PD).We and others reported recently that expression of the pathogenic gain-of-function mutant form of LRRK2,LRRK2 G2019S,induc...
关键词：LRRK2 Parkinson’s disease MITOPHAGY ULK1 JNK DLP1 
Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats:Implication for immunosuppressive therapy in Parkinson’s disease被引量：5
《Neuroscience Bulletin》2008年第3期133-142,共10页高俊鹏 孙珊 李文伟 陈依萍 蔡定芳 
Objective Neuroinflammation with microglial activation has been implicated to have a strong association with the progressive dopaminergic neuronal loss in Parkinson＇s disease （PD）. The present study was undertaken ...
关键词：Parkinson＇s disease TRIPTOLIDE MICROGLIA neurons 
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