PARKINSON_DISEASE

作品数:123被引量:198H指数:7
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相关作者:余舒扬陈滢陈晓春王涛张巧俊更多>>
相关机构:首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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相关基金:国家自然科学基金北京市自然科学基金国家重点基础研究发展计划陕西省自然科学基金更多>>
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Efficacy and safety of light therapy for Parkinson disease被引量:2
《Chinese Medical Journal》2022年第7期878-880,共3页Yanghong Li Xiaoxia Zhou Xinyin Wu Beisha Tang 
the National Natural Science Foundation of China(No.81430023)。
To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disorder associated with significant disability and negative impact on quality of life(QoL),affecting 2%to 3%of the population≥65 years o...
关键词:IMPAIRMENT RIGIDITY typically 
Transcranial sonography in differential diagnosis of Parkinson disease and other movement disorders被引量:5
《Chinese Medical Journal》2021年第14期1726-1731,共6页Li-Shu Wang Teng-Fei Yu Bin Chai Wen He 
the National Natural Science Foundation of China(No.81730050).
Background:Reports evaluating the efficacy of transcranial sonography(TCS)for the differential diagnosis of Parkinson disease(PD)and other movement disorders in China are scarce.Therefore,this study aimed to assess th...
关键词:Transcranial sonography Movement disorders Parkinson disease 
Fatigue correlates with sleep disturbances in Parkinson disease被引量:3
《Chinese Medical Journal》2021年第6期668-674,共7页Xiang-Yang Cao Jin-Ru Zhang Yun Shen Cheng-Jie Mao Yu-Bing Shen Yu-Lan Cao Han-Ying Gu Fen Wang Chun-Feng Liu 
National Key R&D Program of China(No.2017YFC0909100);National Natural Science Foundation of China(Nos.91649114;81801259);Jiangsu Provincial Key R&D Program(No.BE2018658);Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022);Jiangsu Provincial social development projects(No.BE2017653);Suzhou Clinical Research Center of Neurological Disease(No.Szzx201503);Pre-research project for doctors of the Second Affiliated Hospital of Soochow University(No.SDFEYBS1910)。
Background: Many Parkinson disease (PD) patients complain about chronic fatigue and sleep disturbances during the night. The objective of this study is to determine the relationship between fatigue and sleep disturban...
关键词:FATIGUE Parkinson disease POLYSOMNOGRAPHY Sleep behavior disorder 
Voxel-based analysis of brain microstructural diffusion indices changes in Parkinson disease with freezing of gait被引量:1
《Chinese Medical Journal》2021年第2期249-251,共3页Jing-Wu Chen Fa-Ze Mai Yong-Zhe Yang Wan-Qun Yang Li-Juan Wang Kun Nie Biao Huang 
supported by grants from the Key R&D Program of Guangdong Province,China(No.2018B030339001);the National Natural Science Foundation of China(No.81671275)。
To the Editor:Freezing of gait(FOG)is a common disabling movement disorder in Parkinson disease(PD),affecting approximately 50%to 80%of PD patients in their late state.FOG can cause the patients to fall easily,serious...
关键词:IMPAIRED indices DIFFUSION 
Positron emission computed tomography/single photon emission computed tomography in Parkinson disease被引量:5
《Chinese Medical Journal》2020年第12期1448-1455,共8页Nian-Ting Yao Qian Zheng Zi-Qian Xu Jian-Hong Yin Lin-Guang Lu Qi Zuo Su Yang Chun-Lin Zhang Ling Jiao 
This work was supported by grants from the National Key Laboratory of Infectious Disease Prevention and Control Independent Research Open Project(No.2018SKLID307);Science and Technology Fund Project of Guizhou Health and Health Commission(No.gzwjkj2019-1-065);Science and Technology Plan Project of Guiyang(No.[2017]30-30);the Department of Science and Technology of Guizhou Province(No.[2017]5718).
Parkinson disease(PD)is the second-most common neurodegenerative disorder.Its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra an...
关键词:Parkinson disease Positron emission computed tomography Single photon emission computed tomography Dopamine transporter ^18F-fluorodeoxyglucose 
Substantia nigra hyperechogenicity in Parkinson disease patients with leucine-rich repeat kinase 2 variants in the Chinese Han population
《Chinese Medical Journal》2020年第12期1483-1484,共2页Kai Li Chen-Chen Gu Jin-Ru Zhang Hong Jin Yi-Lun Ge Jing Chen Ya-Ping Yang Fen Wang Cheng-Jie Mao Ying-Chun Zhang Chun-Feng Liu 
This work was supported by grants from the National Key R&D Program of China(No.2017YFC0909100);the National Natural Science Foundation of China(No.81801120);the Initial Scientific Research Fund at the Second Affiliated Hospital of Soochow University(No.SDFEYBS1702);Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022);Jiangsu Provincial social development projects(No.BE2018658 and BE2017653);Suzhou Clinical Research Center of Neurological Disease(No.Szzx201503).
To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disease,and is characterized by both motor and non-motor symptoms.The leucine-rich repeat kinase 2(LRRK2)gene,characterized by different m...
关键词:PATIENTS CLINICAL MUTATION 
Quantitative autonomic function test in differentiation of multiple system atrophy from idiopathic Parkinson disease被引量:1
《Chinese Medical Journal》2019年第16期1919-1924,共6页Ji-Yun Park Dongseok Yang Hei-Jun Yang Hyun Ah Kim Saeromi Kim Deokhyun Heo Jeong-Ho Park Eek-Sung Lee Tae-Kyeong Lee 
Background:Differential diagnosis of idiopathic Parkinson disease (IPD) and multiple system atrophy-Parkinson type (MSA-P) is challenging since they share clinical features with parkinsonism and autonomic dysfunction....
关键词:PARKINSON disease Multiple system ATROPHY AUTONOMIC DYSFUNCTION Cardiovascular AUTONOMIC indexes 
Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease被引量:4
《Chinese Medical Journal》2017年第15期1856-1866,共11页Juan-Juan Du Sheng-Di Chen 
This work was supported by grants from the National Natural Science Foundation of China (No. 81371407 and No. 81430022).
Objective:The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD).Data Sources:Papers in English published in PubMed,Cochra...
关键词:DYSKINESIAS Motor Fluctuations Nondopaminergic Options Parkinson Disease 
Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease被引量:3
《Chinese Medical Journal》2017年第9期1085-1092,共8页Si-Yue Li Ya-Li Wang Wen-Wen Liu Dong-Jun Lyu Fen Wang Cheng-Jie Mao Ya-Ping Yang U-Fang Hu Chun-Feng Liu 
This work was supported by grants from the National Natural Science Foundation of China (No. 91649114),Jiangsu Provincial Special Program of Medical Science (No. BL2014042), the Plans for Graduate Research and Innovation in Colleges and Universities of Jiangsu Province (No. KYZZ15_0334), and Suzhou Clinical Research Center of Neurological Disease (No. Szzx201503). This was also partly supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Jiangsu Provincial Medical Key Discipline Project.
Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in pati...
关键词:Circadian Rhythm LEVODOPA Oxidopamine Parkinson Disease 
Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A 5-year Follow-up Study in China被引量:13
《Chinese Medical Journal》2015年第18期2433-2438,共6页Lu-Lu Jiang Jin-Long Liu Xiao-Li Fu Wen-Biao Xian Jing Gu Yan-Mei Liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen 
Background: Subthalarnic nucleus deep brain stimulation (STN DBS) is effective against advanced Parkinson's disease (PD), allowing dramatic improvement of Parkinsonism, in addition to a significant reduction in ...
关键词:Deep Brain Stimulation Follow-Up Studies Parkinson Disease Subthalamic Nucleus Treatment Outcome 
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