the National Natural Science Foundation of China(No.81430023)。
To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disorder associated with significant disability and negative impact on quality of life(QoL),affecting 2%to 3%of the population≥65 years o...
the National Natural Science Foundation of China(No.81730050).
Background:Reports evaluating the efficacy of transcranial sonography(TCS)for the differential diagnosis of Parkinson disease(PD)and other movement disorders in China are scarce.Therefore,this study aimed to assess th...
National Key R&D Program of China(No.2017YFC0909100);National Natural Science Foundation of China(Nos.91649114;81801259);Jiangsu Provincial Key R&D Program(No.BE2018658);Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022);Jiangsu Provincial social development projects(No.BE2017653);Suzhou Clinical Research Center of Neurological Disease(No.Szzx201503);Pre-research project for doctors of the Second Affiliated Hospital of Soochow University(No.SDFEYBS1910)。
Background: Many Parkinson disease (PD) patients complain about chronic fatigue and sleep disturbances during the night. The objective of this study is to determine the relationship between fatigue and sleep disturban...
supported by grants from the Key R&D Program of Guangdong Province,China(No.2018B030339001);the National Natural Science Foundation of China(No.81671275)。
To the Editor:Freezing of gait(FOG)is a common disabling movement disorder in Parkinson disease(PD),affecting approximately 50%to 80%of PD patients in their late state.FOG can cause the patients to fall easily,serious...
This work was supported by grants from the National Key Laboratory of Infectious Disease Prevention and Control Independent Research Open Project(No.2018SKLID307);Science and Technology Fund Project of Guizhou Health and Health Commission(No.gzwjkj2019-1-065);Science and Technology Plan Project of Guiyang(No.[2017]30-30);the Department of Science and Technology of Guizhou Province(No.[2017]5718).
Parkinson disease(PD)is the second-most common neurodegenerative disorder.Its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra an...
This work was supported by grants from the National Key R&D Program of China(No.2017YFC0909100);the National Natural Science Foundation of China(No.81801120);the Initial Scientific Research Fund at the Second Affiliated Hospital of Soochow University(No.SDFEYBS1702);Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022);Jiangsu Provincial social development projects(No.BE2018658 and BE2017653);Suzhou Clinical Research Center of Neurological Disease(No.Szzx201503).
To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disease,and is characterized by both motor and non-motor symptoms.The leucine-rich repeat kinase 2(LRRK2)gene,characterized by different m...
Background:Differential diagnosis of idiopathic Parkinson disease (IPD) and multiple system atrophy-Parkinson type (MSA-P) is challenging since they share clinical features with parkinsonism and autonomic dysfunction....
This work was supported by grants from the National Natural Science Foundation of China (No. 81371407 and No. 81430022).
Objective:The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD).Data Sources:Papers in English published in PubMed,Cochra...
This work was supported by grants from the National Natural Science Foundation of China (No. 91649114),Jiangsu Provincial Special Program of Medical Science (No. BL2014042), the Plans for Graduate Research and Innovation in Colleges and Universities of Jiangsu Province (No. KYZZ15_0334), and Suzhou Clinical Research Center of Neurological Disease (No. Szzx201503). This was also partly supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Jiangsu Provincial Medical Key Discipline Project.
Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in pati...
Background: Subthalarnic nucleus deep brain stimulation (STN DBS) is effective against advanced Parkinson's disease (PD), allowing dramatic improvement of Parkinsonism, in addition to a significant reduction in ...