supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC);the National Key R&D Program of China,No.2023YFE0209500(to JC);China Postdoctoral Science Foundation,No.2023M732380(to NY);Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC);National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM);Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily inv...
Objective To explore the correlations of transcranial sonography of substantia nigra(SN-TCS)characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease(PD).Methods Data of SN-TCS an...
Introduction: Quality of life in Parkinson disease is not necessary linked to motor symptoms. It’s correlated of overactive bladders and prostatic symptoms. Prognosis factors of urinary quality of life are unknown. O...
This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked a...
Background: Parkinson’s disease (PD) is a complex, multifactorial neurodegenerative disorder with a pathophysiology deriving from the synergy of abnormal aggregation of neuroinflammation, synuclein and dysfunction of...
the National Natural Science Foundation of China(Grant Nos.12072236,11872276,and11802086);the Postdoctoral Research Project of Henan Province,China(Grant No.19030095);the Science and Technology Development Program of Henan Province,China(Grant No.212102210543)。
Seizures are caused by increased neuronal firing activity resulting from reduced inhibitory effect and enhancement of inhibitory modulation to suppress this activity is used as a therapeutic tool.However,recent experi...
the National Natural Science Foundation of China(No.81430023)。
To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disorder associated with significant disability and negative impact on quality of life(QoL),affecting 2%to 3%of the population≥65 years o...
Fondazione Cariverona:“Development and validation of a novel molecular assay forα-synuclein in patients with Parkinson’s disease and otherα-synucleinopathies”#2018.0708 to GZ and Brain Research Verona Foundation to GZ.Dr.Elena Fontana is attending a doctoral fellowship supported by COPAN group.
Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucle...
Background: Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Bladder dysfunction is the common non-motor symptom of PD, most often presenting with ...
OBJECTIVE Nicotinamide phos⁃phoribosyltransferase(NAMPT)is the key enzyme for the synthesis of nicotinamide ade⁃nine dinucleotide(NAD)in the salvaging pathway.NAD is an essential co-enzyme of multiple enzymes involved...