PEPTIDE

作品数：1070被引量：2052H指数：15
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Enhanced glioma-targeting and stability of ~LGICP peptide coupled with stabilized peptide ~DA7R被引量：5
《Acta Pharmaceutica Sinica B》2018年第1期106-115,共10页Mingfei Zhang Weiyue Lu 
supported by National Basic Research Program of China (973 Program, No. 2013CB932500);National Natural Science Foundation of China (Nos. 81773657, 81690263 and 81473149);Shanghai Education Commission Major Project (No. 2017-01-07-00-07-E00052);Shanghai International Science and Technology Cooperation Project (No.16430723800)
Malignant glioma is usually accompanied by vigorous angiogenesis to provide essential nutrients. An effective glioma targeting moiety should include excellent tumor-cell homing ability as well as good neovasculature-t...
关键词：GLIOMA NEOVASCULATURE Target PEPTIDE Stabilization Blood–tumor barrier 
Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration被引量：7
《Regenerative Biomaterials》2017年第1期21-30,共10页Xiaoli Wu Liumin He Wen Li Heng Li Wai-Man Wong Seeram Ramakrishna Wutian Wu 
The authors thank for funding supports from the National Program on Key Basic Research Project(973 Program,2014CB542205);Hong Kong RGC grant(17124514);Foundation for Distinguished Young Talents in Higher Education of Guangdong(Yq2013023);Pearl River Nova Program of Guangzhou(2014J2200001);China Postdoctoral Science Foundation(2013M540684);the Leading Talents of Guangdong Province(87014002);National Natural Science Foundation of China(51103062);The authors wish to acknowledge the support from the Hong Kong Scholars Program(XJ2012024).
Peripheral nerves are fragile and easily damaged,usually resulting in nervous tissue loss,motor and sensory function loss.Advances in neuroscience and engineering have been significantly contributing to bridge the dam...
关键词：Peripheral nerve regeneration self-assembling peptide IKVAV RGD nanofibrous hydrogel 
Self-assembling peptide nanofibrous hydrogel as a promising strategy in nerve repair after traumatic injury in the nervous system被引量：1
《Neural Regeneration Research》2016年第5期717-718,共2页Na Zhang Liumin He Wutian Wu 
supported by National Basic Research Program of China(973 Program,2014CB542205);Hong Kong RGC grant;Hong Kong Health and Medical Research Fund;foundation for Distinguished Young Talents in Higher Education of Guangdong(Yq2013023);the Leading Talents of Guangdong Province(87014002)
Following injury in central nervous system（CNS）,there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.T...
关键词：NSCs Self-assembling peptide nanofibrous hydrogel as a promising strategy in nerve repair after traumatic injury in the nervous system RGD 
CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan被引量：9
《World Journal of Gastroenterology》2015年第5期1518-1530,共13页Ping Li Xu-Dong Tang Zheng-Xu Cai Juan-Juan Qiu Xue-Lian Lin Tong Zhu Lawrence Owusu Hui-Shu Guo 
Supported by National Natural Science Foundation of China,No.81273919;Grants from the Natural Science Foundation of Liaoning Province,No.2012225020 and No.2013023002;the National Basic Research Program of China(973 Program),No.2013CB531703
AIM:To investigate the distribution and expressionof C-type natriuretic peptide(CNP)/natriuretic peptide receptor B(NPR-B) in the rectum of a rodent depression model and the interventional effect of Xiaoyaosan(XYS).ME...
关键词：C-Type NATRIURETIC PEPTIDE NATRIURETIC PEPTIDE rec 
Chemical synthesis of a cyclotide via intramolecular cyclization of peptide O-esters被引量：5
《Science China Chemistry》2012年第1期64-69,共6页ZHENG Ji-Shen CHANG Hao-Nan SHI Jing LIU Lei 
supported by the National Natural Science Foundation of China(20932006,91013007);the National Basic Research Program of China(973 Program)(2011CB965300)
Cyclotides constitute a fascinating family of circular proteins containing ca.30 amino acid residues.They have a unique cyclic cysteine knot topology and exhibit remarkable thermal,chemical and enzymatic stabilities.T...
关键词：CYCLOTIDES chemical synthesis peptide O-ester native chemical ligation MACROLACTAMIZATION 
Binding of EGF1 Domain Peptide in Coagulation Factor Ⅶ with Tissue Factor and Its Implications for the Triggering of Coagulation被引量：3
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2010年第1期42-47,共6页梅恒 胡豫 王华芳 石威 邓君 郭涛 
supported by grants from National Basic Research Program of China(973 Program,No.2007CB935803);National Natural Sciences Foundation of China(No.30825018)
The binding function of EGF1 domain peptide with tissue factor(TF)and its ability of triggering coagulation were explored.The TF expression model in vitro was established by lipopolysaccha-ride induction.The affinity ...
关键词：coagulation factor Ⅶ epidermal growth factor-like domain tissue factor ANTICOAGULATION 
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