PEPTIDE

作品数：1070被引量：2052H指数：15
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Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy
《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang 
supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).
Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...
关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery 
A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy
《Chinese Chemical Letters》2025年第1期397-402,共6页Cheng-Zhe Gao Hao-Ran Jia Tian-Yu Wang Xiao-Yu Zhu Xiaofeng Han Fu-Gen Wu 
supported by the Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education(No.GKE-KF202305);the Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,and the Natural Science Foundation of Jiangsu Province(No.BK20211510)。
Vascular disrupting agents(VDAs)can destroy tumor vasculature and lead to tumor ischemia and hypoxia,resulting in tumor necrosis.However,VDAs are easy to induce the upregulation of genes that are associated with cance...
关键词：Tumor-homing peptide LIPOSOME Vascular disrupting agents CHEMOTHERAPY Hypoxia-activated 
Peptide-based strategies for overcoming multidrug-resistance in cancer therapy
《Chinese Chemical Letters》2025年第1期110-118,共9页Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan 
supported by the Science and Technology Innovation Program of Hunan Province(No.2022RC1168);National Natural Science Foundation of China(Nos.82322073,82173846,82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302);China Postdoctoral Science Foundation(No.2021M702215);Oriental Scholars of Shanghai Universities(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine(No.CACM-(2021-QNRC2-A08));Shanghai Rising-Star Program(No.22QA1409100);Shanghai Sailing Program(No.22YF1445000);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program(Nos.ZY(2021-2023)-0208,ZY(2021-2023)-0401);High level Key Discipline of National Administration of Traditional Chinese Medicine(No.71);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology。
Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for...
关键词：Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics IMMUNOTHERAPY Medicinal chemistry 
Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery
《Chinese Chemical Letters》2024年第12期245-248,共4页Weiyu Chen Zenghui Li Chenguang Zhao Lisha Zha Junfeng Shi Dan Yuan 
supported by the National Natural Science Foundation of China(No.21975068);Natural Science Foundation of Hunan(No.2022JJ10008);Science and Technology and Development Foundation of Shenzhen(No.JCYJ20210324122403010);Natural Science Foundation of Changsha(No.kq2202152)。
Achieving selectivity in cell penetrating peptide(CPP)design is crucial to mitigate systemic toxicity and enable precise targeting based on distinct cellular phenotypes.Herein,we designed an amphiphilic peptide,L17Yp,...
关键词：Enzymatic action DEPHOSPHORYLATION Conformation shift Cell-penetrating peptide Selective delivery 
An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy:Real-time tumor-tracking and chemical-enhanced photodynamic therapy
《Chinese Chemical Letters》2024年第12期254-259,共6页Jia-Qi Feng Xiang Tian Rui-Ge Cao Yong-Xiu Li Wen-Long Liu Rong Huang Si-Yong Qin Ai-Qing Zhang Yin-Jia Cheng 
financially supported by Natural Science Foundation of China(Nos.52173295,52273313,22377152,52202357);the Fundamental Research Funds for the Central Universities,South-Central Minzu University(Nos.CZQ23036,CZY22005);the Knowledge Innovation Program of Wuhan-Basic Research(No.2023020201010150)。
The combination of diagnostic and therapeutic agents in the form of theranostic platforms to enhance tumor therapeutic efficacy is receiving increasing attention in recent years.However,simultaneous encapsulation,embe...
关键词：Photodynamic-chemotherapy Co-assembly AIE photosensitizer Peptide drug THERANOSTICS 
Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages
《Chinese Chemical Letters》2024年第11期299-303,共5页Cheng-Yan Wu Yi-Nan Gao Zi-Han Zhang Rui Liu Quan Tang Zhong-Lin Lu 
the financial support by the National Natural Science Foundation of China(Nos.91227109 and 21778012 to Z.-L.Lu.,No.21801020 to R.Liu);Bohai University。
Constructing more stable self-assembled organic nanotubes has been one of the focuses of scientists in recent decades.Hexakis(m-phenylene ethynylene)(m-PE)benzene macrocycles can form stable tubular self-assemblies in...
关键词：Macrocyclic compounds Supramolecular assembly Ion transportation Synthetic ion channels Molecular nanotubes 
A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy被引量：1
《Chinese Chemical Letters》2024年第10期353-359,共7页Han Han Bi-Te Chen Jia-Rong Ding Jin-Ming Si Tian-Jiao Zhou Yi Wang Lei Xing Hu-Lin Jiang 
financially supported by the National Natural Science Foundation of China(Nos.82020108029,82073398);the National Key Research and Development Program of China(No.2022YFE0198400);supported by Double FirstRate construction plan of China Pharmaceutical University(No.CPU2022QZ18)。
Activated pancreatic stellate cells(PSCs)are the main source of collagen layer deposition and the key target in pancreatic fibrosis.However,no effective treatment specific to pancreatic fibrosis clinically,owing to th...
关键词：Pancreatic fibrosis Pancreatic stellate cells LIPOSOME PDGFRβ pPB peptide 
Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines
《Chinese Chemical Letters》2024年第6期316-319,共4页Jianhui Yin Wenjing Huang Changyong Guo Chao Liu Fei Gao Honggang Hu 
the financial support from the National Natural Science Foundation of China(No.22107062);the National Natural Science Foundation of Shanghai(No.21ZR1422600)。
Tryptophan(Trp)carries a unique heteroaromatic indole side chain and plays a critical role in peptide or protein modification.Herein,we have reported a metal-free photoinduced N-H alkylation strategy using N-aryl glyc...
关键词：TRYPTOPHAN PEPTIDE MODIFICATION Glycine PHOTOINDUCED 
TCP-1,a novel peptide to diagnose early colon cancer
《Chinese Chemical Letters》2024年第3期226-233,共8页Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-027);National Natural Science Foundation of China(Nos.T2192972,81402997);Key Project of Beijing Natural Science Foundation(No.7181007);National High-tech Research and Development Plan(863 Plan,No.2014AA020803);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study(No.Z141102004414062)。
A nine cyclic peptide(TCP-1)showed excellent specificity for colon cancer.TCP-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagno...
关键词：Colon cancer TCP-1 PEPTIDE Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD) 
Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy
《Chinese Chemical Letters》2024年第1期237-242,共6页Yunqi Liu Junliang Zhou Zhankui Sun 
Unnatural amino acids(UAAs)have broad applications in pharmaceutical sciences and biological studies.Current synthetic methods for UAAs mainly rely on asymmetric catalysis and often require several steps.There is a la...
关键词：Unnatural amino acids Peptide modifications DESULFURIZATION CYSTEINE Radical addition 
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