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PEPTIDE: 作品数：1062被引量：2043H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨松成张学敏张滨魏开华王红霞更多>>; 相关机构：北京大学福建医科大学复旦大学军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications: 《Chemical Research in Chinese Universities》2022年第4期856-865,共10页XU Min ZHOU Baomei DING Yan DU Shanshan SU Mengke LIU Honglin; supported by the National Key Research and Development Program of China(No.2019YFC1605900);the National Natural Science Foundation of China(Nos.21922403,21874034);the Key Research and Development Project of Anhui Province,China(No.202104a07020013);the Fundamental Research Funds for the Central Universities,China(Nos.PA2020GDJQ0030,JZ2021HGTA0171,JZ2021HGQA0243);the Anhui Provincial Natural Science Foundation,China(No.2108085QB84).; Nucleic acids form biological blueprint and polypeptides assist life activities,both of which are indispensable to organisms.Recently,oligonucleotide-peptide complexes(OPCs)have shown great potential in biomedicine,ma...; 关键词：OLIGONUCLEOTIDE PEPTIDE COMPLEX

In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis: 《Chemical Research in Chinese Universities》2021年第4期855-869,共15页YANG Jia ZHENG Rui AN Hongwei WANG Hao; This work was supported by the National Natural Science Foundation of China(Nos.52003270,51725302,11621505);the National Key R&D Program of China(No.2020YFA0210800);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000);the Key Research Program for Frontier Sciences,Chinese Academy of Sciences(No.ZDBS-LY-SLH039).; In vivo imaging is creating great opportunities for disease diagnosis as a research tool. Probes are usually used to observe physiological structures in vivo clearly. Recent progresses of nanoprobes are important for ...; 关键词：In vivo self-assembly NANOPROBE PEPTIDE Disease diagnosis

In situ Activatable Peptide-based Nanoprobes for Tumor Imaging: 《Chemical Research in Chinese Universities》2021年第4期889-899,共11页LIU Zhiyu LIANG Gaolin ZHAN Wenjun; This work was supported by the National Natural Science Foundation of China(Nos.22074016,21725505,81821001).; Owing to its excellent biological properties,peptide has been widely used in the design of nanoprobes capable of enhancing tumor imaging signals.In recent years,a number of peptide-based nanoprobes with strong loading...; 关键词：Tumor imaging Peptide-based nanoprobe In situ activatable Self-assembly

Effect of a Short Peptide with Alternating L-and D-Amino Acid on the Aggregation and Membrane Damage of hIAPP: 《Chemical Research in Chinese Universities》2021年第3期787-794,共8页MENG Feihong WANG Yajie LU Tong WANG Chunyu LI Fei; This work was supported by the National Natural Science Foundation of China(No.21673099).; Alpha-sheet is believed to be a significant structural compo-nent,formed in the fibrillation process of the amyloid pep-tide.However,the knowledge about the role of a-sheet played in the amyloidosis and toxicity is la...; 关键词：Alpha-sheet Amyloid peptide TOXICITY

Chemical Synthesis of Proteins Containing 300 Amino Acids被引量：4: 《Chemical Research in Chinese Universities》2020年第5期733-747,共15页ZHANG Baochang LI Yulei SHI Weiwei WANG Tongyue ZHANG Feng LIU Lei; Supported by the National Key R&D Program of China(No.2017YFA0505200);the National Natural Science Foundation of China(Nos.21532004,91753205,81621002).; Chemical synthesis of proteins containing up to 300 amino acids may cover 30%—50%of all the proteins encountered in biomedical studies and may provide an alternate approach to the usually used recombinant expression ...; 关键词：Chemical protein synthesis Solid-phase synthesis PEPTIDE LIGATION 300 amino acid

Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking被引量：1: 《Chemical Research in Chinese Universities》2020年第5期962-969,共8页YU Wenting XUE Bin ZHU Zhenshu SHEN Ziqin QIN Meng WANG Wei CAO Yi; Supported by the National Natural Science Foundation of China(Nos.1180414&1193400,11674153,81622033,21774057);the Natural Science Foundation of Jiangsu Province,China(No.BK20180320);the Fundamental Research Funds for the Central Universities,China(Nos,020414380080,020414380118);the Basic Research Project of Science and Technology Plan of Shenzhen,China(No.JC YJ20170818110643669).; Injectable hydrogels are ideal biomaterials tor delivering cells,growth tactors and dmgs specifically to localized lesions and subsequent controlled release.Many factors can a fleet the efficacy of injectable hydrogel...; 关键词：Peptide-ion coordination Ligand cooperativity Tnjectable hydrogek Mechanical response

Synthesis of a Heptapeptide and Its Application in the Detection of Mercury（Ⅱ） Ion被引量：1: 《Chemical Research in Chinese Universities》2017年第2期155-159,共5页FENG Huiyun GAO Lei YE Xinhui WANG Lei XUE Zechun KONG Jinming LI Lianzhi; A new heptapeptide, Cys-Pro-Gly-Cys-Pro-Gly-Cys-CONH2（P7）, was prepared via Fmoc solid-phasepepfide synthesis, purified by high performance liquid chromatography（HPLC） and characterized by mass spectro-metry（MS）...; 关键词：PEPTIDE HG^2+ DETECTION GOLD NANOPARTICLE Absorption spectrum

Gene Manipulation Based Selenium-containing Peptide Exhibiting Synergism of SOD and GPx被引量：1: 《Chemical Research in Chinese Universities》2014年第6期947-952,共6页SHEN Na YAN Fei LU Shaowu YANG Wenkui LUO Guimin YAN Ganglin MU Ying; Supported by the National Natural Science Foundation of China（Nos.31170740, 31270907） and the Natural Science Founda- tion of Jilin Province, China（No.20130101159JC）.; In this paper, we constructed a novel bifunctional superoxide dismutase（SOD）/glutathione peroxi- dase（GPx） mimic, a selenium-, copper-containing 35-mer peptide conjugate（Se-Cu-35P） in which a three-amino acid li...; 关键词：Reactive oxygen species Superoxide dismutase Glutathione peroxidase Bifunctional enzyme

Responses of Transmembrane Peptide and Lipid Chains to Hydrophobic Mismatch: 《Chemical Research in Chinese Universities》2012年第4期732-736,共5页YANG Lei LI Jian-tao QI Hai-yan LI Fei; Supported by the National Natural Science Foundation of China(Nos.20973083,20934002); Hydrophobic mismatch between the hydrophobic length of membrane proteins and hydrophobic thickness of membranes is a crucial factor in controlling protein function and assembly.We combined fluorescence with circular d...; 关键词：Hydrophobic mismatch Transmembrane peptide Fluorescence Circular dichroism（CD） Attenuated total reflection infrared（ATR-IR）

Studies on Fragmentation of Peptide by Nano-electrospray Ionization Fourier Transform Ion Cyclotron Resonance Multi-stage Tandem Mass Spectrometry: 《Chemical Research in Chinese Universities》2011年第5期773-776,共4页SHI Ying LIU Ning SONG Feng-rui LIU Zhi-qiang LIU Shu-ying; Supported by the National Natural Science Foundation of China(No.20675079); The sequence analysis of peptides was performed by nano-electrospray ionization Fourier transform ion cyclotron resonance tandem mass spectrometry（Nano-ESI-FT-ICR-MSn） and several peptides were chosen as examples. W...; 关键词：Nano-electrospray ionization Fourier transform ion cyclotron resonance tandem mass spectrometry（Nano-ESI-FT-ICR-MS） Collision induced dissociation（CID） Peptide sequence

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