PEPTIDE

作品数：1062被引量：2043H指数：15
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Peptide nanozymes:An emerging direction for functional enzyme mimics
《Bioactive Materials》2024年第12期284-298,共15页Shaobin He Long Ma Qionghua Zheng Zhuoran Wang Wei Chen Zihang Yu Xiyun Yan Kelong Fan 
funded by the Key Project of the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China(U23A20686);the Key Laboratory of Biomacromolecules,Chinese Academy of Sciences(ZGD-2023-03);the Joint Funds for the Innovation of Science and Technology,Fujian Province(2023Y9226);the Introduced High-Level Talent Team Project of Quanzhou City(2023CT008).
The abundance of molecules on early Earth likely enabled a wide range of prebiotic chemistry,with peptides playing a key role in the development of early life forms and the evolution of metabolic pathways.Among peptid...
关键词：PEPTIDE Nanozyme Enzyme mimic Structure-activity relationship Biomedical applications 
Recent research of peptide-based hydrogel in nervous regeneration
《Bioactive Materials》2024年第10期503-523,共21页Chunmei Xie Yueyang Chen Lang Wang Kin Liao Bin Xue Yulong Han Lan Li Qing Jiang 
supported by the National Natural Science Foundation of China(32271408,32271296,12202193);National Basic Research Program of China(2021YFA1201404);Natural Science Foundation of Jiangsu Province(BK20232023);Nanjing Health Technology Development Special Project(JQX23002);Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,the Youth Innovation Team of Shaanxi Universities,China.
Neurological disorders exert significantly affect the quality of life for patients,necessitating effective strategies for nerve regeneration.Both traditional autologous nerve transplantation and emerging therapeutic a...
关键词：SELF-ASSEMBLED DIPEPTIDE Cyclic dipeptide HYDROGELS Nervous regeneration 
Stimuli-responsive peptide assemblies:Design,self-assembly,modulation,and biomedical applications被引量：2
《Bioactive Materials》2024年第5期181-207,共27页Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G.Kumbar 
support from the National Natural Science Foundation of China(No.51873225);the Taishan Scholars Program of Shandong Province(No.tsqn201909104);the High-Grade Talents Plan of Qingdao University.Dr.Kumbar acknowledges the funding support by the National Institutes of Health(#R01NS134604,#R01EB034202,#R01AR078908,#R01EB030060 and,#R56NS122753);the U.S.Army Medical Research Acquisition Activity(USAMRAA),through the CDMRP Peer-Reviewed Medical Research Program(Award No.W81XWH2010321 and PR230581).
Peptide molecules have design flexibility,self-assembly ability,high biocompatibility,good biodegradability,and easy functionalization,which promote their applications as versatile biomaterials for tissue engineering ...
关键词：Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials Biomedical applications 
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration
《Bioactive Materials》2024年第4期181-203,共23页Zhuowen Hao Qinyu Feng Yi Wang Ying Wang Hanke Li Yingkun Hu Tianhong Chen Junwu Wang Renxin Chen Xuan Lv Zhiqiang Yang Jiayao Chen Xiaodong Guo Jingfeng Li 
supported by the National Natural Science Foundation of China(No.82372405,No.81871752);the Fundamental Research Funds for the Central Universities(NO.2042023kf0199);the Key Research and Development Program of Hubei Province(No:2022BCA052);the Key Research and Development Program of Wuhan City(No.2023020402010591);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(No.ZNJC202014).
Supramolecular peptide nanofiber hydrogels are emerging biomaterials for tissue engineering,but it is difficult to fabricate multi-functional systems by simply mixing several short-motif-modified supramolecular peptid...
关键词：Supramolecular peptide nanofiber hydrogels Parathyroid hormone SELF-ASSEMBLY Co-assembly Bone tissue engineering 
Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment被引量：6
《Bioactive Materials》2024年第1期231-246,共16页Fan Zhang Mingchen Lv Siyuan Wang Mengyao Li Yu Wang Congjiao Hu Wei Hu Xuekui Wang Xiaogang Wang Zhiduo Liu Zhen Fan Jianzhong Du Yao Sun 
financially supported by National Key R&D Program of China(2022YFA1103200);National Natural Science Foundation of China(81822012,82061130222,81771043,22075212,21925505,52222306,22075212);Shanghai Academic Leader of Science and Technology Innovation Action Plan(20XD1424000);Innovation Program of Shanghai Municipal Education Commission(2023ZKZD28);the Shanghai Experimental Animal Research Project of Science and Technology Innovation Action Plan(8191101676,201409006400);Shanghai International Scientific Collaboration Fund(21520710100).
The immune microenvironment plays a vital role in bone defect repair.To create an immune microenvironment that promotes osteogenesis,researchers are exploring ways to enhance the differentiation of M2-type macrophages...
关键词：PEPTIDE Nanofiber hydrogel Immune microenvironment Bone tissue regeneration 
Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration被引量：2
《Bioactive Materials》2023年第12期85-97,共13页Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong Gu Yumin Yang 
the National Natural Science Foundation of China(No.32230057,32271389,31900987);Jiangsu Natural Science Foundation(No.BK20200974);Heilongjiang Natural Science Foundation(No.YQ2019H022);Shuangchuang Program of Jiangsu Province(No.JSSCBS20211603);Nantong Municipal Commission of Health and Family Planning(No.MB2021011);Nantong Science and Technology Plan Project(No.MSZ2022196);Nantong Science and Technology Plan Project(No.JC2019146);Nantong University Clinical Medicine Project(No.2019JZ004).
Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple cel...
关键词：Bionic peptide scaffolds Peripheral nerve regeneration MACROPHAGES Conditional media Immune microenvironment 
A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery被引量：1
《Bioactive Materials》2023年第7期783-795,共13页Sunfan Li Fangzhou Li Dong Wan Zuqin Chen Jie Pan Xing-Jie Liang 
This work was supported by the National Key Research and Development Program of China(grant Nos.2021YFA1201000 and 2018YFE0117800);the National Natural Science Foundation of China(NSFC)key project(grant No.32030060);the NSFC International Collaboration Key Project(grant No.51861135103);the National Natural Science Foundation of China(grant No.22078246,22178270 and 82102204);The authors also appreciate the support by“the Beijing-Tianjin-Hebei Basic Research Cooperation Project”(19JCZDJC64100);the China Postdoctoral Science Foundation funded project(grant No.2020M680478).
Chemotherapy remains the mainstay of cancer treatment,benefiting millions of patients each year,but the side effects of chemotherapy drugs severely limit their clinical use.Doxorubicin(DOX)can cause various side effec...
关键词：DOXORUBICIN Delivery PEPTIDE Missiles CHEMOTHERAPY 
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal被引量：5
《Bioactive Materials》2023年第4期47-59,共13页Yanan Sun Bochen Lyu Chang Yang Bing He Hua Zhang Xueqing Wang Qiang Zhang Wenbing Dai 
This work was supported by the National Key R&D Program of China(2017YFA0205600);Natural Science Foundation of Hebei Province(H2022206171)。
Mild photothermal therapy combined with immune checkpoint blockade has received increasing attention for the treatment of advanced or metastatic cancers due to its good therapeutic efficacy.However,it remains a challe...
关键词：Transformable nanomedicine Self-assembled peptide Immune checkpoint blockade Photothermal therapy Photoimmunotherapy 
Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration被引量：9
《Bioactive Materials》2023年第2期418-433,共16页Yue Xu Yuan You Luyao Yi Xiaoyi Wu Yaning Zhao Jian Yu He Liu Ya Shen Jingmei Guo Cui Huang 
supported by the National Natural Science Foundation of China(No.82001106,81970918,81901043).
Dental caries is one of the most prevalent human diseases resulting from tooth demineralization caused by acid production of bacteria plaque.It remains challenges for current practice to specifically identify,interven...
关键词：Biofilms Dental caries Micelles PEPTIDE Stimuli responsive polymers Tooth remineralization 
Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy被引量：1
《Bioactive Materials》2023年第2期519-527,共9页Leman Buzoglu Kurnaz Yuanyuan Luo Xiaoming Yang Amjed Alabresm Ryan Leighton Rani Kumar JiHyeon Hwang Alan W.Decho Prakash Nagarkatti Mitzi Nagarkatti Chuanbing Tang 
Facial amphiphilicity is an extraordinary chemical structure feature of a variety of antimicrobial peptides and polymers.Vast efforts have been dedicated to small molecular,macromolecular and dendrimer-like systems to...
关键词：ANTIMICROBIAL Facial amphiphilicity Chemical structure PEPTIDE 
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