PHOSPHATASE

作品数：255被引量：886H指数：14
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相关机构：中国科学院遗传与发育生物学研究所山东大学湖北中医药大学安徽中医学院第一附属医院更多>>
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Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis被引量：1
《Cell Research》2023年第3期245-257,共13页Wencheng Zhu Huiying Chu Yajuan Zhang Tianhang Luo Hua Yu Hongwen Zhu Ye Liu Hong Gao Yun Zhao Quanlin Li Xiongjun Wang Guohui Li Weiwei Yang 
This work was supported by the National Natural Science Foundation of China(92253305,92053203 and 32025013)to W.Y.;the National Key R&D Program of China(2022YFA0806201 and 2019YFA0802000)to W.Y.;CAS Project for Young Scientists in Basic Research(YSBR-014)to W.Y.;Program of Shanghai Academic/Technology Research Leader(20XD1424400)to W.Y.;the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212302)to W.Y.;the Strategic Priority Research Program of Chinese Academy of Sciences(XDB 37000000)to G.L.;the National Natural Science Foundation of China(21933010)to G.L.;the National Natural Science Foundation of China(21907094)to H.C.;the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022265)to Y.Zhang;Shanghai Science and Technology Development Funds(22QA1409900)to Y.Zhang.We gratefully acknowledge the support of the Sanofi Scholarship Program.We also thank all the core facilities of Shanghai Institute of Biochemistry and Cell Biology for technical support.
Emerging evidence demonstrates that some metabolic enzymes that phosphorylate soluble metabolites can also phosphorylate a variety of protein substrates as protein kinases to regulate cell cycle,apoptosis and many oth...
关键词：IΚBΑ COLORECTAL STIMULATION 
The noncanonical role of the protease cathepsin D as a cofilin phosphatase被引量：1
《Cell Research》2021年第7期801-813,共13页Yi-Jun Liu Ting Zhang Sicong Chen Daxiao Cheng Cunjin Wu Xingyue Wang Duo Duan Liya Zhu Huifang Lou Zhefeng Gong Xiao-Dong Wang Margaret S.Ho Shumin Duan 
supported by National Key Research and Development Program of China(2016YFA0501000);National Natural Science Foundation of China(81821091,31501128,31490592,31871039,81971260,81761138044,81527901,81801330,and 91832000);Key Research and Development Program of Zhejiang Province(2020C03009);Science and Technology Planning Project of Guangdong Province(2018B030331001);Key Realm R&D Program of Guangdong Province(2019B030335001);Chinese Ministry of Education Project 111 Program(B13026).
Cathepsin D(cathD)is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments.Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remode...
关键词：CATHEPSIN CANONICAL traditionally 
CaMKIIα-driven,phosphatase-checked postsynaptic plasticity via phase separation被引量：4
《Cell Research》2021年第1期37-51,共15页Qixu Caic Menglong Zeng Xiandeng Wu Haowei Wu Yumeng Zhan Ruijun Tian Mingjie Zhang 
supported by a grant from the Simons Foundation(Award ID:510178);grants from RGC of Hong Kong(16101419,AoE-M09-12 and C6004-17G);a grant from the Minister of Science and Technology of China(2019YFA0508402)to M.Z.M.Z.is a Kerry Holdings Professor of Science,a Croucher Foundation Senior Fellow and a Senior Fellow of IAS at HKUST.
Ca^(2+)/calmodulin-dependent kinase Ila(CaMKIla)is essential for synaptic plasticity and learning by decoding synaptic Ca^(2+)oscillations.Despite decades of extensive research,new mechanisms underlying CaMKIIa's func...
关键词：CAMKII inhibited checked 
An HNF 1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells被引量：16
《Cell Research》2015年第8期930-945,共16页Hui Qian Xing Deng Zhao-Wei Huang Ji Wei Chen-Hong Ding Ren-Xin Feng Xin Zeng Yue-Xiang Chen Jin Ding Lei Qiu Zhen-Lin Hu Xin Zhang Hong-Yang Wang Jun-Ping Zhang Wei-Fen Xie 
Acknowledgment We thank Dr Zhao-Hui Wei （TigerMed Co., Ltd., Shanghai, China） for assistance on statistical analysis. This work was supported by the National Natural Science Foundation of China （81470871 ; Key Program, 81230011; Creative Research Groups, 30921006） and Shanghai Science and Technology Committee for the Key Projects （13JC1407400）.
Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α（HNF1α） is a liver-enriched transcription factor that pla...
关键词：Hepatocyte nuclear factor 1α liver fibrosis SH2 domain-containing phosphatase-1 microRNA feedback CROSSTALK 
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes被引量：2
《Cell Research》2014年第9期1067-1090,共24页Hong-Mei Wang Yun-Fei Xu Shang-Lei Ning Du-Xiao Yang Yi Li Yu-Jie Du Fan Yang Ya Zhang Nan Liang Wei Yao Ling-Li Zhang Li-Chuan Gu Cheng-Jiang Gao Qi Pang Yu-Xin Chen3 Kun-Hong Xiao Rong Ma Xiao Yu Jin-Peng Sun 
Acknowledgments This work was supported by the National Key Basic Research Program of China （2013CB967700 to X Yu; 2012CB910402 to JP Sun）, the National Natural Science Foundation of China （31000362 to X Yu, 31100580 and 31271505 to JP Sun, and 81171062 to Q Pang）, and the Shandong Natural Science Fund for Distinguished Young Scholars （JQ201320 to X Yu）, the Fundamental Research Funds of Shandong University （2014JC029 to X Yu）, the State Key Laboratory of Cell Biology and the Program for Changjiang Scholars and Innovative Research Team in University （IRT 13028）.
The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HE...
关键词：PHOSPHATASE receptor UBIQUITINATION HER2 PTPN18 EGFR 
Structural basis of PP2A activation by PTPA, an ATP- dependent activation chaperone被引量：3
《Cell Research》2014年第2期190-203,共14页Feng Guo Vitali Stanevich Nathan Wlodarchak Ritupama Sengupta Li Jiang Kenneth A Satyshur Yongna Xing 
Proper activation of protein phosphatase 2A （PP2A） catalytic subunit is central for the complex PP2A regulation and is crucial for broad aspects of cellular function. The crystal structure of PP2A bound to PP2A phos...
关键词：PHOSPHATASE CHAPERONE ACTIVATION PP2A cell proliferation and survival catalytic metal ions 
Phospho-control of TGF-β superfamily signaling被引量：28
《Cell Research》2009年第1期8-20,共13页Katharine H Wrighton Xia Lin Xin-Hua Feng 
Members of the transforming growth factor-β （TGF-β） family control a broad range of cellular responses in metazoan organisms via autocrine, paracrine, and endocrine modes. Thus, aberrant TGF-β signaling can play ...
关键词：SMAD PHOSPHORYLATION PHOSPHATASE TGF-β signaling 
rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells被引量：1
《Cell Research》2007年第11期919-932,共14页Yiyuan Yuan Xiang Gao Ning Guo Hui Zhang Zhiqin Xie Meilei Jin Baoming Li LeiYu Naihe Jing 
We thank Dr Bin Zhang （University of Michigan, USA） for providing the MCFD2 antibodies. This work was supported in part by the Life Science Special Fund of the Chinese Academy of Sciences for Human Genome Research （KJ95T-06 and KSCX1-Y02 to BML, NHJ and MLJ）, the National Natural Science Foundation of China （30225023 and 30430240 to BML and 90208011, 30300174, 30470856, 30421005 and 30623003 to NHJ）, the National Key Basic Research and Development Program of China （2006CB500807 to BML and 2002CB713802, 2005CB522704 and 2006CB943902 to NHJ）, the National High-Tech Research and Development Program of China （2006AA02ZI99 to BML and 2006AA02Z186 to NHJ）, the Shanghai Key Project of Basic Science Research （04DZ14005 to BML and 04DZ14005, 04DZ05608, 06DJI4001 and 06DZ22032 to NHJ）, the Council of the Shanghai Municipal for Science and Technology （05814578 to NHJ）, and the US National Institutes of Health （DA013471 and DA020555 to LY）.
Sac domain-containing proteins belong to a newly identified family of phosphoinositide phosphatases （the PIPPase family）. Despite well-characterized enzymatic activity, the biological functions of this mammalian Sac...
关键词：PIPPase intracellular membrane trafficking neurite outgrowth 
Differential expression of a cDNA clone in human liverversus hepatic cancer-highly homologous to aryl-dialkyl-phosphatase
《Cell Research》1997年第1期79-90,共12页WANG KAN KAN DA FANG WAN XIAO KUN QIU PEI XIN LU JIAN REN GU(National La6oratory for Oncogenes and Related Genes Shanghai Cancer Institute, Shanghai 200032)(Qidong Cancer Institute, Jiangsu 226200) 
We applied the technique of mRNA differential display to normal liver tissue and hepatoma cell line Hep3B. One of the isolated cDNA clones was expressed in human normal liver tissue but not in the human hepatocarcinom...
关键词：HEPATOCARCINOMA mRNA DD aryl-dialkyl-phosphatase 
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