PROTEASOME

作品数：158被引量：433H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：邹晓民徐萍田蕊李卉王超更多>>
相关机构：北京大学苏州大学北京协和医学院吉林大学第二医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Proteasome phase separation: a novel layer of quality control被引量：2
《Cell Research》2020年第5期374-375,共2页Victoria Cohen-Kaplan Ido Livneh Aaron Ciechanover 
Maintenance of the quality control of the cellular proteome involves several pathways and a variety of transient and interchangeable assemblies.A recently discovered membraneless foci that contain一am ong several comp...
关键词：SEPARATION apparatus CARRY 
High-resolution cryo-EM structure of the proteasome in complex with ADP-AIFx被引量：1
《Cell Research》2017年第3期373-385,共13页Zhanyu Ding Zhenglin Fu Cong Xu Yifan Wang Yanxing Wang Junrui Li Liangliang Kong Jinhuan Chen Na Li Rongguang Zhang Yao Cong 
We thank Drs Ji.nqiu Zhou and Zhaocai Zhou （Institute of Bio- chemistry and Cell Biology, Shanghai） for their generous support. We thank Yingyi Zhang and Mi Cao from the Electron Microscopy facility and Min Xue from Data Base ＆ Computation system at National Centre for Protein Science Shanghai （NCPSS） for their assistance with the EM instrument management and data storage and parallel computing. We are grateful to the NCPSS Protein Expression and Purification facility, Mass Spectrometry facili- ty, and BL19U2 beamline at NCPSS and Shanghai Synchrotron Radiation Facility （SSRF） for instrument support and technical assistance. This work was supported by grants from the CAS Pilot Strategic Science and Technology Projects B （XDB08030201）, the National Natural Science Foundation of China （31270771, 31670754）, the National Basic Research Program of China （2013CB910401）, the STS program of the CAS （KFJ-EW-STS-098）, and the CAS-Shanghai Science Research Center （CAS- S SRC-YH-2015-01）.
The 26S proteasome is an ATP-dependent dynamic 2.5 MDa protease that regulates numerous essential cellular functions through degradation of ubiquitinated substrates. Here we present a near-atomic-resolution cryo-EM ma...
关键词：high-resolution cryo-EM PROTEASOME activated state asymmetric nucleotide occupancy 
The life cycle of the 26S proteasome： from birth, through regulation and function, and onto its death被引量：13
《Cell Research》2016年第8期869-885,共17页Ido Livneh Victoria Cohen-Kaplan Chen Cohen-Rosenzweig Noa Avni Aaron Ciechanover 
Research in the laboratory of AC is supported by grants from the Dr Miriam and Sheldon G Adelson Medical Research Foundation （AMRF）, the Israel Science Foundation （ISF）, the I-CORE. Program of the Planning and Budgeting Committee and the ISF （Grant1775/12）, and the DeutschIsraelische Projektkooperation （DIP）. IL is supported by the Foulkes Fellowship. AC is an Israel Cancer Research Fund （ICRF） USA Professor.
The 26S proteasome is a large, -2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nucl...
关键词：UBIQUITIN PROTEASOME 
Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis被引量：3
《Cell Research》2014年第10期1214-1230,共17页Tao Yu Yonghui Tao Meiqiang Yang Peng Chen Xiaobo Gao Yanbo Zhang Tao Zhang Zi Chen Jian Hou Yan Zhang Kangcheng Ruan Hongyan Wang Ronggui Hu 
We are grateful to Dr W Bian and her team in Cell Biology Core facility of SIBCB for their excellent support in flow cytometry analysis and cell sorting, and Drs L Lin, Y Xia and H Xiao of National Center for Microarrays for their help in microarray analysis. We are particularly grateful to Dr Hsueh-Chi Yen at Institute of Mol Biol, Academia Sinica, and Dr Ivan Dikic of Goethe University for advice, and Drs Dangsheng Li, Lijian Hui and Jiarui Wu of SIBCB, and Dr Shirley Diamond of California Institute of Tech- nology for helpful discussion. We also thank Dr Ya-lan Wu and all other members of the Hu lab for support. This work was supported by the National Natural Science Foundation of China （31270828, 31070678, 81170491, 81072070 and 81470360）, the 100 Talents award from CAS to RH and the Ministry of Science and Technology, China （2010CB912100, 2012CB910800 and 2013CB910900 to RH, and 2011CB915501 to KR）. RH was also supported by a Sanofi-aventis SIBS Young Investigator award and funding from the Cancer Center of Xuhui Central Hospital （CCR2012003）, Shanghai Institute of Neurosciences （SKLN-201206） and the Instrument Developing Project of the Chinese Academy of Sciences （YZ201339）.
Global change in protein turnover （protein degradome） constitutes a central part of cellular responses to intrin- sic or extrinsic stimuli. However, profiling protein degradome remains technically challenging. Recen...
关键词：BORTEZOMIB combination therapy PROTEOSTASIS protein degradome proteasome homeostasis N-end role ubiquitin 
Proteasome-independent p53 degradation
《Cell Research》2013年第5期597-598,共2页Mais M Nuaaman Samuel Benchimol 
The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in CellResearch identifies a proteasomeindepende...
关键词：P53蛋白 降解途径 蛋白酶体 抑制蛋白 细胞内 元器件 DEF 肿瘤 
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation被引量：10
《Cell Research》2013年第5期620-634,共15页Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng 
p53 protein turnover through the ubiquitination pathway is a vital mechanism in the regulation of its transcriptional activity; however, little is known about p53 turnover through proteasome-independent pathway（s）. ...
关键词：Def P53 A 133p53/A 113p53 ubquitination CALPAIN digestive organ development NUCLEOLUS 
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies被引量：5
《Cell Research》2012年第8期1227-1245,共19页Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock 
Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a large-scale loss-...
关键词：KRAS synthetic lethal oncogene addiction PROTEASOME TOPOISOMERASE 
Proteostasis regulation at the endoplasmic reticulum： a new perturbation site for targeted cancer therapy被引量：1
《Cell Research》2011年第6期867-883,共17页Yanfen Liu Yihong Ye 
To deal with the constant challenge of protein misfolding in the endoplasmic reticulum （ER）, eukaryotic cells have evolved an ER protein quality control （ERQC） mechanism that is integrated with an adaptive stress ...
关键词：retrotranslocation/ERAD/dislocation ER stress/UPR PROTEASOME BH3-only protein IRE1 PERK ubiquitin p97/Cdc48 targeted cancer therapy bortezomib/Velcade 
Physiological levels of ATP negatively regulate proteasome function被引量：4
《Cell Research》2010年第12期1372-1385,共14页Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu 
Acknowledgments This work was supported by the National High Technol- ogy Research and Development Program of China （Project 2006AA02Z4B5）, the National Natural Science Foundation of China （Project 2010）, and a Key Project （9251018201002） of Guangdong Province Natural Science Foundation （to JL）. It was also supported in part by Grants HL072166, HL085629, and HL068936 of the NIH and an Established Investigator Award （0740025N） of the American Heart Association （to XW）.
Intracellular protein degradation by the ubiquitin-proteasome system is ATP dependent, and the optimal ATP concentration to activate proteasome function in vitro is -100 μM. IntraceUular ATP levels are generally in t...
关键词：ATP PROTEASOME REGULATION APOPTOSIS 
Regulating the stability of TGFβ receptors and Smads被引量：39
《Cell Research》2009年第1期21-35,共15页Peter Lonn Anita Moren Erna Raja Markus Dahl Aristidis Moustakas 
Transforming growth factor β （TGFβ） controls cellular behavior in embryonic and adult tissues. TGFβ binding to serine/threonine kinase receptors on the plasma membrane activates Smad molecules and additional sign...
关键词：LYSOSOME phosphorylation PROTEASOME Smad SUMO TGFΒ UBIQUITIN 
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