云南高校图书馆联盟文献共享服务平台- PROTEIN

PROTEIN: 作品数：2328被引量：5787H指数：25; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：邢苗李根喜刘晓灵梁毅杨芃原更多>>; 相关机构：中国科学院北京大学第二军医大学复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Insertion of unnatural metal ligand in the heme pocket of nitrophorin through protein semi-synthesis:Toward biomimicking binuclear active sites: 《Chinese Chemical Letters》2023年第12期132-135,共4页Yonglu Chen Yi Zhou Chunmao He; financial support from the National Natural Science Foundation of China(Nos.22077036 and 22277029)is greatly acknowledged.; Herein,we report a semi-synthetic strategy affording a nitrophorin 2(NP2)variant with a N,N'-bis(2-pyridylmethyl)amine(Dpa)ligand as sidechain selectively installed at position 27,which was assembled from a synthetic ...; 关键词：Protein semi-synthesis Protein modification Nitrophorin2 Heteronuclear active site Native chemical ligation

A fluorogenic probe for SNAP-tag protein based on ESPT ratiometric signals被引量：1: 《Chinese Chemical Letters》2023年第5期641-644,共4页Jin Li Qinglong Qiao Yiyan Ruan Ning Xu Wei Zhou Guixin Zhang Jingli Yuan Zhaochao Xu; supported by the National Natural Science Foundation of China(Nos.22225806,22078314 and 22278394);Dalian Institute of Chemical Physics(Nos.DICPI202227 and DICPI202142)。; Protein self-labeling tags achieve selective fusion and labeling of target proteins through genetic coding technology,but require exogenous fluorescent probes with fluorogenicity for protein tag binding to have the pe...; 关键词：Fluorogenic probe RATIOMETRIC ESPT SNAP-TAG Wash-free imaging

Chemical tools for E3 ubiquitin ligase study: 《Chinese Chemical Letters》2023年第4期67-74,共8页Yangwode Jing Chong Zuo Yun-Xiang Du Junxiong Mao Ruichao Ding Jiachen Zhang Lu-Jun Liang Qian Qu; E3 ubiquitin ligases catalyze the final step of ubiquitylation,a crucial post-translational modification involved in almost every process in eukaryotic cells.E3 ubiquitin ligases are key regulators of cellular events,...; 关键词：Chemical tools Protein chemical synthesis UBIQUITYLATION E3 ligase Enzymatic mechanism

Rational design of a turn-on fluorescent probe for visualization of GRP78 protein in tumor models: 《Chinese Chemical Letters》2023年第3期352-355,共4页Ying Wen Ning Jing Fangjun Huo Caixia Yin; National Natural Science Foundation of China(Nos.21705102,21775096,22074084);the Basic Research Program of Shanxi Province(Free Exploration)(No.20210302123430)。; Fluorescence image for accurate tumor label still faces challenges in cancer detection and diagnostics.Emerging evidence is indicating that glucose-regulated protein 78(GRP78), a stress-inducible protein chaperone, is...; 关键词：Glucose-regulated protein 78 Fluorescence probe Living cell imaing Tumor diagnosis

Protein nanoparticles containing Cu(Ⅱ)and DOX for efficient chemodynamic therapy via self-generation of H_(2)O_(2)被引量：2: 《Chinese Chemical Letters》2020年第12期3127-3130,共4页Rui Cao Wen Sun Zheng Zhang Xiaojing Li Jianjun Du Jiangli Fan Xiaojun Peng; the National Natural Science Foundation of China(Nos.21808028,21925802,21878039,21421005);NSFC-Liaoning United Fund(Nos.U1608222,U1908202)。; Chemodynamic therapy(CDT)refers to generating hydroxyl radical(OH)in tumor sites via hydrogen peroxide(H_(2)O_(2))catalyzed by transition metal ions in cancer cells under acidic environment.However,H_(2)O_(2) content ...; 关键词：Chemodyamic therapy DOXORUBICIN Hydrogen peroxide Fenton-like reaction Hydroxyl radical

Highly-efficient photosensitizer based on AIEgen-decorated porphyrin for protein photocleaving: 《Chinese Chemical Letters》2019年第11期1965-1968,共4页Qiang Wang Qingqing Chen Guoyu Jiang Mengting Xia Mengjiao Wang Yongdong Li Xiaoming Ma Jianguo Wang Xinggui Gu; National Natural Science Foundation of China(Nos.21663005,21871060,21804022 and 21702016);the Natural Science Foundation of Jiangxi Province(Nos.2018ACB21009,20181BAB213007);the Science and Technology Project of the Education Department of Jiangxi Province of China(No.GJJ170846);the Special Graduate Student Innovation Fund of Jiangxi Province(No.YCX18B007);Beijing National Laboratory for Molecular Sciences(No.BNLMS201813)for the financial support; An AIEgen decorated porphyrin(TPETPyP)was easily obtained through a one-step reaction.The bulky TPE in TPETPyP greatly impeded the intermolecularπ-πstacking of the porphyrin core,which significantly suppressed aggre...; 关键词：AIEgen PORPHYRIN Singlet oxygen quantum yield Protein photoclevage

Small molecule fluorescent probes of protein vicinal dithiols被引量：1: 《Chinese Chemical Letters》2019年第10期1704-1716,共13页Guodong Hu Huiyi Jia Lanning Zhao Dong-Hyung Cho Jianguo Fang; financial supports from the National Natural Science Foundation of China (Nos. 21572093 & 21778028);the 111 Project; The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical propertie...; 关键词：FLUORESCENT PROBE PROTEIN VICINAL DITHIOLS Arsenical PROBE THIOL redox Reaction-based PROBE

Chemical synthesis and structure determination of venom toxins被引量：1: 《Chinese Chemical Letters》2019年第7期1369-1373,共5页Bobo Dang; Venom toxins are widely spread in nature, adopting diverse structures and functions. They often function by blocking or modulating important membrane protein targets thus can be promising therapeutic candidates and bi...; 关键词：VENOM TOXINS Chemical PROTEIN synthesis STRUCTURE DETERMINATION PROTEIN foldin RACEMIC PROTEIN crystallography

Interchain doubly-bridged α-helical peptides for the development of protein binders: 《Chinese Chemical Letters》2019年第4期924-928,共5页Yaqi Chen Jingjing Liang Tao Li Ping Lin Yibing Zhao Chuanliu Wu; financial support from the National Natural Science Foundation of China (Nos. 21675132 and 21822404);the Program for Changjiang Scholars and Innovative Research Team in University (No. 13036);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No. 21521004); Constrained peptide scaffolds that are tolerant to extensive sequence manipulation and amenable to bioactive peptide design are of great value to the development of novel protein binders and peptide therapeutics. In t...; 关键词：PEPTIDES α-Helices PROTEIN binders Bisthioether crosslinkers MDM2-P53 INTERACTIONS

Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide被引量：1: 《Chinese Chemical Letters》2018年第7期1135-1138,共4页Chenchen Chen Shuai Gao Qian Qu Pengcheng Mi Anjin Tao Yi-Ming Li; supported by the National Natural Science Foundation of China (NSFC No. 21572043);the Fundamental Research Funds for the Central Universities (No. PA2017GDQT0021); Guanylate cyclase C(GC-C) is an important receptor protein expressed by intestinal epithelial cells, and its dysregulation leads to severe intestinal diseases. Linaclotide is a 14-amino acid peptide approved by the FD...; 关键词：Linaclotide Guanylyl cyclase Protein chemical synthesis Fmoc solid phase peptide synthesis Racemic crystallization

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