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From sequence to mechanobiology?Promises and challenges for AlphaFold 3被引量：1: 《Mechanobiology in Medicine》2024年第3期1-3,共3页Francesco Zonta Sergio Pantano; supported by Xi'an Jiaotong-Liverpool University(Research Development Fund RDF-23-01-026 to F.Z);FOCEM(MERCOSUR Structural Convergence Fund-COF 03/11)to S.P.; Interactions between macromolecules orchestrate many mechanobiology processes.However,progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures.In recen...; 关键词：AlphaFold Protein folding Biological complexes Structure predictions Drug design

SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor: 《Acta Pharmaceutica Sinica B》2023年第7期3043-3053,共11页Yiqun Li Mingrui Yang Yanan Nan Jiaming Wang Sanjiao Wang Dongxiao Cui Jiajian Guo Pengfei He Wenxin Dai Shuqi Zhou Yue Zhang Wenfu Ma; supported by Startup fund program at Beijing University of Chinese Medicine(BUCM)(90011451310011,China)to Wenfu Ma;the emergency fund against COVID-19 program at BUCM(1000061223476,China)to Wenfu Ma;the innovation team and talents cultivation program of national administration of traditional Chinese medicine(ZYYCXTD-C202006,China)to Wenfu Ma。; Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S...; 关键词：COPI inhibitor SARS-CoV-2 spike Spike sorting motifs Protein folding Protein trafficking Anti-COVID-19 Omicron variants and drug discovery

A small molecule UPR modulator for diabetes identified by high throughput screening被引量：2: 《Acta Pharmaceutica Sinica B》2021年第12期3983-3993,共11页Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen; supported by the Juvenile Diabetes Research Foundation (JDRF) [3-PAR-2016-241-I-X, US]。; Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding ...; 关键词：βcells Unfolded protein response Small molecules Protein folding Endoplasmic reticulum CHAPERONES Cell signaling DIABETES ER stress Liver PANCREAS Metabolic diseases

A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction被引量：10: 《Acta Pharmacologica Sinica》2021年第10期1598-1609,共12页Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang; This work was supported by Health and Medical Research Fund[Grant numbers 05162906 and 05161746];Early Career Scheme[Grant number 24122318];the National Natural Science Foundation of China[Grant numbers 91739103 and 91939302];Hong Kong Research Grants Council[Grant numbers 14112919 and C4024-16W].; Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endot...; 关键词：HOMOCYSTEINE GLP-1 analog EXENDIN-4 AMPK ER stress ER chaperone oxidative stress endothelial dysfunction

Equilibrium folding and unfolding dynamics to reveal detailed free energy landscape of src SH3 protein by magnetic tweezers被引量：2: 《Chinese Physics B》2021年第7期595-599,共5页Huanhuan Su Hao Sun Haiyan Hong Zilong Guo Ping Yu Hu Chen; the National Natural Science Foundation of China(Grant Nos.11874309 and 11474237);the 111 Project(Grant No.B16029)。; Src SH3 protein domain is a typical two-state protein which has been confirmed by research of denaturant-induced unfolding dynamics.Force spectroscopy experiments by optical tweezers and atomic force microscopy have m...; 关键词：protein folding and unfolding magnetic tweezers free energy landscape transition state

A critical role of the thioredoxin domain containing protein 5(TXNDC5) in redox homeostasis and cancer development被引量：5: 《Genes & Diseases》2018年第4期312-322,共11页Hedy A.Chawsheen Qi Ying Hong Jiang Qiou Wei; This work was partially supported by the National Institutes of Health(NCI grant number R01CA222596);Department of Defense(grant number W81XWH-16-1-0203);American Cancer Society(grant number RSG-16-213-01-TBE);Kentucky Lung Cancer Research Program(KLCRP2016).; Correct folding of nascent peptides occurs in the endoplasmic reticulum(ER).It is a complicate process primarily accomplished by the coordination of multiple redox proteins including members of the protein disulfide i...; 关键词：CANCER Cell signal Protein disulfide isomerase Protein folding Receptor modulation

Visualized and precise design of artificial small RNAs for regulating T7 RNA polymerase and enhancing recombinant protein folding in Escherichia coli被引量：1: 《Synthetic and Systems Biotechnology》2016年第4期265-270,共6页Yujia Zhao Jingjing Fan Jinlin Li Jun Li Xiaohong Zhou Chun Li; The author would like to acknowledge the National Science Fund for Distinguished Young Scholars(21425624);the National Natural Science Foundation of China(21476026,21376028).; Small non-coding RNAs(sRNAs)have received much attention in recent years due to their unique biological properties,which can efficiently and specifically tune target gene expressions in bacteria.Inspired by natural sR...; 关键词：Artificial small RNAs Visualized and precise design Prokaryotic T7 expression system Inclusion body

Protein Folding Mediated by an Intramolecular Chaperone: Energy Landscape for Unimolecular Pro-Subtilisin E Maturation: 《Advances in Bioscience and Biotechnology》2015年第2期73-88,共16页Ezhilkani Subbian Danielle M. Williamson Ujwal Shinde; Efficient and precise assembly of polypeptides into native functional states is critical for normal cellular processes. Understanding how a specific structure is encoded in the polypeptide sequence and what drives the...; 关键词：PROPEPTIDE Dependent Folding PROTEASE Activation Subtilases ENERGETICS PROPROTEIN Convertases

How the “Folding Funnel” Depends on Size and Structure of Proteins?A View from the Scoring Function Perspective: 《Tsinghua Science and Technology》2013年第5期462-468,共7页Sheng-You Huang Gordon K. Springer; The support of the UMBC; It has been well accepted that the folding energy landscape may resemble a funnel according to the theory of protein folding. This theory of ＂folding funnel＂ has been extensively studied and thought to play an impor...; 关键词：energy landscape folding funnel protein structure prediction scoring function protein folding

Protein folding, protein homeostasis,and cancer被引量：1: 《Chinese Journal of Cancer》2011年第2期124-137,共14页John H. Van Drie; Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperone...; 关键词：蛋白质折叠蛋白质平衡癌症化疗药物氨基酸序列三维结构蛋白合成细胞

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