supported by the Fujian Provincial Health Technology Project(China)(No.2023QNA016);the Guidance in Medical and Health Program of Xiamen,China(No.3502Z20209120);Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University(China)(No.PM201809170018).
Mutations in fibrillin-1 gene(FBN1)have been shown to be associated with Marfan syndrome and most FBN1 mutations display missense or nonsense.Recently,reports on synonymous mutation-related diseases have attracted wid...
Elite Young Scientists Program of CAAS;National Natural Science Foundation of China,Grant/Award Numbers:32150025,31725002;Guangdong Provincial Key Laboratory of Synthetic Genomics,Grant/Award Number:2023B1212060054;Shenzhen Outstanding Talents Training Fund;Science and Technology Planning Project of Guangdong Province,Grant/Award Number:2022A0505090009;Bureau of International Cooperation,Chinese Academy of Sciences,Grant/Award Number:172644KYSB20180022;Innovation Program of Chinese Academy of Agricultural Sciences;Shenzhen Science and Technology Program,Grant/Award Number:KQTD20180413181837372;National Key Research and Development Program of China,Grant/Award Number:2022YFF1201800;Shenzhen Key Laboratory of Synthetic Genomics,Grant/Award Number:ZDSYS201802061806209。
The emergence and development of sequencing and DNA synthesis techniques have empowered us with the ability to read and write genomes,thereby enhancing our understanding and manipulation of biological processes.Over t...
supported by the National Key Research and Development Program of China(2021YFC2103300);National Natural Science Foundation of China(32161133019 and 32200067);Major Science and Technology Support Program Project in Hebei Province(24292902Z);Key Research and Development Program Projects of Hebei Province(22322905D);Industry University Research Cooperation Project of Shijiazhuang and University of Hebei province(241490062A);supported by Tianjin Industrial Synthetic Biology Innovation Team.
The yeast Saccharomyces cerevisiae is a well-studied unicellular eukaryote with a significant role in the biomanufacturing of natural products,biofuels,and bulk and value-added chemicals,as well as the principal model...
supported by the National Natural Science Foundation of China(32202125);the Science and Technology Plan Project of Shaoxing City,China(2022A12003);the Zhejiang Provincial Natural Science Foundation,China(LY24C200004).
This study investigated the use of raspberry extract(RBE) for mitigating ethyl carbamate(EC) accumulation in Chinese rice wine(Huangjiu), a traditional fermented beverage. It focused on the addition of RBE to the ferm...
supported financially by National Key Research and Development Program(No.2022YFE0108500);National Natural Science Foundation of China(No.21978168)to X.-Q.Z;JFQ appreciates the grant from Sichuan Natural Science Foundation(No.2023NSFSC0132).
Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast strains.Therefore,the cellulosic ethanol industry requires yeast strains that can tolerate acetic ...
supported by National Key Research and Development Program of China(2020YFA0908000);Prof.Zhubo Dai was supported by Youth Innovation Promotion Association of CAS(2015138);Haihe Laboratory Disruptive Innovation Talent Program(22HHSWSS00026);supported by the Key Project at Central Government Level:The ability establishment of sustainable use for valuable Chinese medicine resources(2060302)。
Background:Heterologous synthesis presents a promising new approach for accessing the active ingredients of traditional Chinese medicine(TCM),contributing to the conservation of natural medicinal resources.Compound Da...
supported by the grant from the National Key Research and Development Program of China(2021YFC2100300);2023 Double World-class Project Key Program“Intelligent Biomanufacturing”.
CoproporphyrinⅢ(CPⅢ),a natural porphyrin derivative,has extensive applications in the biomedical and material industries.S.cerevisiae has previously been engineered to highly accumulate the CPⅢprecursor 5-aminolevu...
supported by the National Key R&D Program of China(2023YFA0913900);the Shenzhen Medical Research Fund(A2303026);the Shenzhen Science and Technology Program(KJZD20230923114415032).
Saccharomyces cerevisiae,a widely utilized model organism,has seen continuous updates to its genome-scale metabolic model(GEM)to enhance the prediction performance for metabolic engineering and systems biology.This st...
support from the National Natural Science Foundation of China(32270087);the Natural Science Foundation of Fujian Province of China(2020J05011);Guangdong Basic and Applied Basic Research Foundation(2021A1515110340);Xiamen University(0660X2510200);Daan Gene(20223160A0063),and ZhenSheng Biotech.
Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical synthesis.In this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the indu...