SACCHAROMYCES_CEREVISIAE

作品数:305被引量:518H指数:10
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The abnormal splicing regulation network caused by synonymous mutations in FBN1 exon 39 leads to Marfan syndrome
《Genes & Diseases》2025年第3期4-6,共3页Fudan Wu Mingjie Li Xuan Zhou Qianyun Wang Yan’an Wu 
supported by the Fujian Provincial Health Technology Project(China)(No.2023QNA016);the Guidance in Medical and Health Program of Xiamen,China(No.3502Z20209120);Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University(China)(No.PM201809170018).
Mutations in fibrillin-1 gene(FBN1)have been shown to be associated with Marfan syndrome and most FBN1 mutations display missense or nonsense.Recently,reports on synonymous mutation-related diseases have attracted wid...
关键词:Marfan syndrome marfan syndrome splicing regulation abnormal splicing synonymous mutation synonymous mutations FBN saccharomyces cerevisiae 
Recent technology advancements in large-scale DNA assembly
《Quantitative Biology》2025年第1期143-151,共9页Jielin Li Li Cheng Yingxin Ma Yizhi Cai Junbiao Dai 
Elite Young Scientists Program of CAAS;National Natural Science Foundation of China,Grant/Award Numbers:32150025,31725002;Guangdong Provincial Key Laboratory of Synthetic Genomics,Grant/Award Number:2023B1212060054;Shenzhen Outstanding Talents Training Fund;Science and Technology Planning Project of Guangdong Province,Grant/Award Number:2022A0505090009;Bureau of International Cooperation,Chinese Academy of Sciences,Grant/Award Number:172644KYSB20180022;Innovation Program of Chinese Academy of Agricultural Sciences;Shenzhen Science and Technology Program,Grant/Award Number:KQTD20180413181837372;National Key Research and Development Program of China,Grant/Award Number:2022YFF1201800;Shenzhen Key Laboratory of Synthetic Genomics,Grant/Award Number:ZDSYS201802061806209。
The emergence and development of sequencing and DNA synthesis techniques have empowered us with the ability to read and write genomes,thereby enhancing our understanding and manipulation of biological processes.Over t...
关键词:saccharomyces cerevisiaewith synthetic yeast genome sequencing dna synthesis techniques understanding manipulation biological processesover sequencing techniques constructed all chromosomes read write genomesthereby artificially synthesized notablythe 
Synthetic evolution of Saccharomyces cerevisiae for biomanufacturing:Approaches and applications
《mLife》2025年第1期1-16,共16页Zhen Wang Xianni Qi Xinru Ren Yuping Lin Fanli Zeng Qinhong Wang 
supported by the National Key Research and Development Program of China(2021YFC2103300);National Natural Science Foundation of China(32161133019 and 32200067);Major Science and Technology Support Program Project in Hebei Province(24292902Z);Key Research and Development Program Projects of Hebei Province(22322905D);Industry University Research Cooperation Project of Shijiazhuang and University of Hebei province(241490062A);supported by Tianjin Industrial Synthetic Biology Innovation Team.
The yeast Saccharomyces cerevisiae is a well-studied unicellular eukaryote with a significant role in the biomanufacturing of natural products,biofuels,and bulk and value-added chemicals,as well as the principal model...
关键词:biomanufacturing metabolic performance Saccharomyces cerevisiae stress tolerance synthetic evolution 
添加乙酸对Saccharomyces cerevisiae L7增产2,3-丁二醇的机理探究
《黑龙江大学自然科学学报》2025年第1期56-62,共7页姚卫格 刘磊 孙蕊 康杰 葛菁萍 
国家自然科学基金资助项目(32071519);黑龙江省省属高校基本科研业务费项目(2023-KYYWF-1448);黑龙江省生态环境厅生态环境保护科研项目(HST20TR004)。
酿酒酵母(Saccharomyces cerevisiae,S.cerevisiae)是生产应用价值较高且可发酵产生清洁化合物2,3-丁二醇(2,3-butanediol)的重要微生物。添加乙酸可以提高S.cerevisiae发酵产2,3-丁二醇的能力,但其机制尚不清楚。本研究在添加乙酸后对...
关键词:酿酒酵母 2 3-丁二醇 合成机制 乙酸调控 
Mitigating ethyl carbamate production in Chinese rice wine:Role of raspberry extract
《Journal of Integrative Agriculture》2025年第1期353-365,共13页Yuxin Liu Chi Shen Xiaoyu Wang Chaogeng Xiao Zisheng Luo Guochang Sun Wenjing Lu Rungang Tian Lijia Dong Xueyuan Han 
supported by the National Natural Science Foundation of China(32202125);the Science and Technology Plan Project of Shaoxing City,China(2022A12003);the Zhejiang Provincial Natural Science Foundation,China(LY24C200004).
This study investigated the use of raspberry extract(RBE) for mitigating ethyl carbamate(EC) accumulation in Chinese rice wine(Huangjiu), a traditional fermented beverage. It focused on the addition of RBE to the ferm...
关键词:Chinese rice wine ethyl carbamate raspberry extract Saccharomyces cerevisiae arginine metabolism 
Overexpression of arginase gene CAR1 renders yeast Saccharomyces cerevisiae acetic acid tolerance
《Synthetic and Systems Biotechnology》2024年第4期723-732,共10页Liang Xiong Ya-Ting Wang Ming-Hai Zhou Hiroshi Takagi Jiufu Qin Xin-Qing Zhao 
supported financially by National Key Research and Development Program(No.2022YFE0108500);National Natural Science Foundation of China(No.21978168)to X.-Q.Z;JFQ appreciates the grant from Sichuan Natural Science Foundation(No.2023NSFSC0132).
Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast strains.Therefore,the cellulosic ethanol industry requires yeast strains that can tolerate acetic ...
关键词:Saccharomyces cerevisiae ARGINASE CAR1 Acetic acid tolerance Amino acid metabolism Ethanol production 
Compound Danshen Yeast 1.0
《Science of Traditional Chinese Medicine》2024年第4期303-311,共9页Rongsheng Li Jie Wang Yuanyuan Han Zhubo Dai 
supported by National Key Research and Development Program of China(2020YFA0908000);Prof.Zhubo Dai was supported by Youth Innovation Promotion Association of CAS(2015138);Haihe Laboratory Disruptive Innovation Talent Program(22HHSWSS00026);supported by the Key Project at Central Government Level:The ability establishment of sustainable use for valuable Chinese medicine resources(2060302)。
Background:Heterologous synthesis presents a promising new approach for accessing the active ingredients of traditional Chinese medicine(TCM),contributing to the conservation of natural medicinal resources.Compound Da...
关键词:Heterologous biosynthesis Compound Danshen preparation Synthetic biology Saccharomyces cerevisiae Compound Danshen Yeast 1.0 
Synergistic increase in coproporphyrinⅢbiosynthesis by mitochondrial compartmentalization in engineered Saccharomyces cerevisiae
《Synthetic and Systems Biotechnology》2024年第4期834-841,共8页Qidi Guo Jiaqi Xu Jiacun Li Shuyan Tang Yuhui Cheng Bei Gao Liang-Bin Xiong Jie Xiong Feng-Qing Wang Dong-Zhi Wei 
supported by the grant from the National Key Research and Development Program of China(2021YFC2100300);2023 Double World-class Project Key Program“Intelligent Biomanufacturing”.
CoproporphyrinⅢ(CPⅢ),a natural porphyrin derivative,has extensive applications in the biomedical and material industries.S.cerevisiae has previously been engineered to highly accumulate the CPⅢprecursor 5-aminolevu...
关键词:CoproporphyrinⅢ Saccharomyces cerevisiae Mitochondrial compartmentalization ANTI-OXIDATION 
Auxotrophy-based curation improves the consensus genome-scale metabolic model of yeast
《Synthetic and Systems Biotechnology》2024年第4期861-870,共10页Siyu Han Ke Wu Yonghong Wang Feiran Li Yu Chen 
supported by the National Key R&D Program of China(2023YFA0913900);the Shenzhen Medical Research Fund(A2303026);the Shenzhen Science and Technology Program(KJZD20230923114415032).
Saccharomyces cerevisiae,a widely utilized model organism,has seen continuous updates to its genome-scale metabolic model(GEM)to enhance the prediction performance for metabolic engineering and systems biology.This st...
关键词:Saccharomyces cerevisiae Genome-scale metabolic model Auxotrophy Flux balance analysis 
Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction被引量:1
《BioDesign Research》2024年第1期20-27,共8页Jian Fan Yang Zhang Wenhao Li Zhizhen Li Danli Zhang Qiwen Mo Mingfeng Cao Jifeng Yuan 
support from the National Natural Science Foundation of China(32270087);the Natural Science Foundation of Fujian Province of China(2020J05011);Guangdong Basic and Applied Basic Research Foundation(2021A1515110340);Xiamen University(0660X2510200);Daan Gene(20223160A0063),and ZhenSheng Biotech.
Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical synthesis.In this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the indu...
关键词:OPTIMIZATION dimension siona multi CAROTENOID CEREVISIAE OVERPRODUCTION SACCHAROMYCES 
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