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SIGNAL_TRANSDUCTION: 作品数：482被引量：3037H指数：28; 导出分析报告; 相关作者：张春翌沈万华袁莉张光毅陈伟更多>>; 相关机构：徐州医学院中国农业大学华中科技大学上海中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2: 《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li; supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals; Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...; 关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

Oxidative stress, nutritional antioxidants and beyond被引量：15: 《Science China(Life Sciences)》2020年第6期866-874,共9页Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin; the National Key Research and Development Program (2016YFD0501204, 2018YFD0500405);the Youth Innovation Promotion Association CAS (2016326);the Science and Technology Projects of Hunan Province (2016SK3022, 2017RS3058);Key Project of Research and Development Plan of Hunan Province (2016NK2170);Science and Technology Projects of Changsha City (kq1801059);Youth Innovation Team Project of ISA, CAS (2017QNCXTD_ZCS);the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-219);the Earmarked Fund for China Agriculture Research System (CARS-35)。; Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated fr...; 关键词：reactive oxygen species oxidative stress mitochondrial dysfunction signal transduction nutritional antioxidant POLYPHENOLS

Plant abiotic stress response and nutrient use efficiency被引量：137: 《Science China(Life Sciences)》2020年第5期635-674,共40页Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu; Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit th...; 关键词：abiotic stress sensing nutrient use efficiency heavy metal Ca2+signaling ROS signal transduction PHOSPHORYLATION transcription factor TRANSPORTER

Recent advances in molecular basis for strigolactone action被引量：13: 《Science China(Life Sciences)》2018年第3期277-284,共8页Ruifeng Yao Jiayang Li Daoxin Xie; supported by the National Key R&D Program of China(2016YFA0500501,2016YFD0101800);the National Natural Science Foundation of China(31630085,91635301);the grant from the China Association for Science and Technology; Strigolactones （SLs） are a very special class of plant hormones, which act as endogenous signals to regulate shoot branching in plants, and also serve as rhizosphere signals to regulate interactions of host plants w...; 关键词：plant hormone STRIGOLACTONE shoot branching PERCEPTION RECEPTOR signal transduction REPRESSOR transcription factor

Diverse roles of SERK family genes in plant growth, development and defense response.被引量：8: 《Science China(Life Sciences)》2016年第9期889-896,共8页Min Fan Minmin Wang Ming-Yi Bai; supported by the National Natural Science Foundation of China(31470376);the"Qilu Scholarship"from Shandong University(11200083963009);"1000-talents Plan"from China for young researchers(11200084963002); Plant receptor-like protein kinases(RLKs) are transmembrane proteins with an extracellular domain and an intracellular kinase domain, which enable plant perceiving diverse extracellular stimuli to trigger the intracel...; 关键词：RLK SERK signal transduction

Ex vivo expansion of hematopoietic stem cells被引量：1: 《Science China(Life Sciences)》2015年第9期839-853,共15页XIE JingJing ZHANG ChengCheng; supported by the National Institutes of Health(1R01CA172268);the Leukemia & Lymphoma Society(1024-14 and TRP-6024-14);the March of Dimes Foundation(1-FY14-201);the Cancer Prevention and Research Institute of Texas(RP140402);the Taishan Scholar Program; Ex vivo expansion of hematopoietic stem cells(HSCs) would benefit clinical applications in several aspects, to improve patient survival, utilize cord blood stem cells for adult applications, and selectively propagate ...; 关键词：ex vivo expansion hematopoietic stem cells NICHE signal transduction cord blood TRANSPLANTATION SCID-repopulating cell genome ed

miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation被引量：11: 《Science China(Life Sciences)》2014年第10期989-997,共9页XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi ZOU YunZeng SUN AiJun QIAN JuYing GE JunBo; supported by the National Natural Science Foundation of China(81100145,81370003,81300082,81370322);the China Postdoctoral Science Foundation funded project(2013M531124,2014T70391);the Cardiovascular Research Fund supported by Chinese Association of Physicians(DFCMDA201259,DFCMDA201255);the Key Specialty Construction of Medical Program in Shanghai(ZK2012A24); microRNA-210(miR-210)has generally been reported to be associated with cell survival under hypoxia.However,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidativ...; 关键词：microRNAs stem cells oxidative stress signal transduction

Biased ligand bonds to make right calls—laboratory of signal transduction reveals molecular mechanism for functional selectivity of GPCR: 《Science China(Life Sciences)》2014年第9期957-958,共2页WANG Jue; In a recent study, Professor Rui-Ping Xiao and her research group at Institute of Molecular Medicine of Peking Univer- sity has provided an essential experimental evidence to support the new paradigm of functional sel...; 关键词：G蛋白偶联受体信号转导功能选择分子机制配体实验证据分子医学生物化学

p75NTR signal transduction suppressed by BFAR and p75NTR interactions被引量：1: 《Science China(Life Sciences)》2012年第4期367-374,共8页LI HongMei SHI HuiLi HUO KeKe; supported by the National High Technology Research and Development Program of China (Grant No. 2006AA02A310);National Science and Technology Key Program of China (Grant Nos. 2008ZX10003-006 and 2009ZX09301011);National Basic Research Program of China (Grant No. 2010CB912609) which were awarded to Huo KeKe; p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death...; 关键词：P75NTR BFAR membrane yeast two-hybrid protein-protein interaction APOPTOSIS

Roles of chromatin assembly factor 1 in the epigenetic control of chromatin plasticity被引量：6: 《Science China(Life Sciences)》2012年第1期15-19,共5页HUANG Hai JIAO RenJie; supported by the National Natural Science Foundation of China (Grant No. 31071087);National Basic Research Program of China (Grant No. 2009CB918702); Genetic information embedded in DNA sequence and the epigenetic information marked by modifications on DNA and his- tones are essential for the life of eukaryotes. Cells have evolved mechanisms of DNA duplication and ...; 关键词：CAF-1 epigenetic information chromatin plasticity signal transduction histone chaperone

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