云南高校图书馆联盟文献共享服务平台- TNB

TNB: 作品数：46被引量：321H指数：10; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：郭彤楼毕研斌龙胜祥赵家通唐劲松更多>>; 相关机构：中国石油化工集团公司中北大学中国石油大学（北京）中国石油化工股份有限公司更多>>; 相关期刊：《湖南师范大学学报（医学版）》《Cellular & Molecular Immunology》《石油物探》《Chinese Journal of Natural Medicines》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省卫生厅资助课题国家高技术研究发展计划更多>>

基于生物信息学和网络药理学的TNBC-PTX耐药机制研究及活性药物预测分析: 《解放军药学学报》2024年第5期415-421,428,共8页吴波蓝晓红王玥坤杨阳易剑峰陈醒; 国家自然科学基金项目,No.82060739;院管课题-基础研究项目,No.2023JCYJYB136。; 目的通过生物信息学和网络药理学方法探讨三阴性乳腺癌紫杉醇(TNBC-PTX)耐药机制及其活性药物筛选。方法利用GEO2R在线分析工具对耐紫杉醇的三阴性乳腺癌相关数据集进行差异分析,获得差异表达基因。随后使用STRING数据库构建蛋白质-蛋...; 关键词：三阴性乳腺癌紫杉醇耐药生物信息学网络药理学

Bone marrow mesenchymal stem cell-induced autophagy ameliorates TNBS-induced experimental colitis by downregulating the NLRP3 inflammasome: 《BIOCELL》2023年第12期2627-2639,共13页JINJIN FU XIAOYUE FENG JUAN WEI XIANG GENG YU GONG FENGDONG LI SHAOHUA ZHUANG JIN HUANG FANGYU WANG; This study aimed to elucidate the potential mechanisms through which bone marrow-derived mesenchymal stem cells(BM-MSCs)may be effective in alleviating experimental colitis induced by treatment with 2,4,6-trinitrobenz...; 关键词：RAW264.7 3-Methyladenine(3-MA) IL1β IL18

取代基对硝基苯热分解机理影响的ReaxFF/lg模拟被引量：2: 《火炸药学报》2023年第5期411-418,I0009,共9页朱双飞朱睿张树海罗春旺冯尚彪刘广瑞; 山西省基础研究计划资助(No.202203021222050,No.202203021212125)。; 使用ReaxFF/lg反应分子动力学模拟,研究了1,3,5-三硝基苯(TNB)、2,4,6-三硝基甲苯(TNT)和2,4,6-三硝基苯胺(TNA)的初始分解反应,通过反应物分解趋势、初始分解路径、重要产物和团簇分析,阐明了甲基和氨基的引入对硝基苯化合物热分解的...; 关键词：物理化学硝基苯取代基热分解机理 ReaxFF/lg TNB TNT TNA

Effect of Baicalin on TNBS-Induced Colonic Inflammatory Injury in Rats被引量：1: 《Health》2023年第9期938-943,共6页Yu Feng Min Guo; Objective: The aim is to observe the protective effect of baicalin on trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis in mice and explore its mechanism. Methods: The mice were divided into 4 groups: ...; 关键词：BAICALIN Trinitrobenzene Sulfonic Acid Experimental Colitis MOUSE

谷氨酰胺合成酶GS通过增强抗凋亡能力降低TNBC细胞对紫杉醇的敏感性被引量：1: 《湖南师范大学学报（医学版）》2023年第3期10-15,共6页朱建余夏弘卓郑卓萌彭小宁邓锡云付淑君; 国家自然科学基金(82103342,82173374); 目的:三阴性乳腺癌(triple-negative breast cancer,TNBC)具有耐药性强的特点,因此,患者会对临床上最常用的化疗药物紫杉醇敏感性降低,从而导致治疗效果不佳。谷氨酰胺合成酶(glutamine synthetase,GS)是合成谷氨酰胺所需的关键代谢酶,...; 关键词：三阴性乳腺癌谷氨酰胺合成酶紫杉醇药物敏感性

四川盆地TNB地区海相气藏构造精细解释与模型评价: 《科学技术创新》2022年第12期185-188,共4页张志超; 构造建模对于提高四川盆地TNB地区海相气藏评价精度具有十分重要的意义。而构造模型主要依靠已钻井资料和地震解释成果。基于此,文章在详细分析研究区构造特征并开展区域精细构造解释基础上,开展了基于井震结合的三维构造建模技术研究,...; 关键词：海相气藏构造特征构造解释构造模型 TNB地区

TNB/1,4⁃DNI共晶炸药的制备与表征被引量：1: 《含能材料》2021年第12期1182-1185,共4页乔申杨宗伟李洪珍于雁武刘玉存王建华; 国家自然科学基金资助(21975233)。; 采用溶剂挥发法制备获得1,3,5⁃三硝基苯/1,4⁃二硝基咪唑(TNB/1,4⁃DNI)共晶炸药,通过单晶X射线衍射表征共晶结构,其晶体属于正交晶系,P2_(1)2_(1)2_(1)空间群,晶胞参数:a=6.4068(5)Å,b=10.4569(8)Å,c=20.7164(17)Å,α=β=γ=90°,ρ=1.77...; 关键词：共晶炸药 1 3 5⁃三硝基苯(TNB) 1 4⁃二硝基咪唑(1 4⁃DNI) 制备结构

Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity被引量：3: 《World Journal of Gastroenterology》2020年第26期3750-3766,共17页Jian-Guo Gao Mo-Sang Yu Meng-Meng Zhang Xue-Wei Gu Yue Ren Xin-Xin Zhou Dong Chen Tian-Lian Yan You-Ming Li Xi Jin; National Natural Science Foundation of China,No.81770574,No.81600414,and No.81600447.; BACKGROUND Conventional Crohn’s disease(CD)treatments are supportive rather than curative and have serious side effects.Adipose-derived mesenchymal stem cells(ADSCs)have been gradually applied to treat various diseas...; 关键词：Crohn’s disease Adipose-derived mesenchymal stem cell Intestinal epithelial cell Wnt pathway T cell Inflammation

Clostridium butyricum alleviates intestinal low-grade inflammation in TNBS-induced irritable bowel syndrome in mice by regulating functional status of lamina propria dendritic cells被引量：25: 《World Journal of Gastroenterology》2019年第36期5469-5482,共14页Qin Zhao Wen-Rong Yang Xiao-Hong Wang Gai-Qin Li Lei-Qi Xu Xiao Cui Yang Liu Xiu-Li Zuo; Supported by the National Natural Science Foundation of China,No.81770538 and No.81570485;Key Research and Development Program of Shandong Province,No.2017CXGC1215; BACKGROUND Irritable bowel syndrome (IBS) is one of the most common functional gastroenterological diseases characterized by abnormal visceral sensitivity and lowgrade inflammation. The role of Clostridium butyricum (...; 关键词：CLOSTRIDIUM butyricum IRRITABLE bowel syndrome LAMINA propria dendritic cells T cell immunoglobulin and MUCIN domain-3 PROINFLAMMATORY cytokines

BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis被引量：11: 《Cellular & Molecular Immunology》2018年第12期1047-1056,共10页Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du; This work was supported by grants from the Ministry of Science and Technology of China(2014CB541903);the National Natural Science Foundation of China(31171348 and 31371414);the Fundamental Research Funds for the Central Universities.; Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DS...; 关键词：TH17 COLITIS IMMUNITY

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