PROINFLAMMATORY

作品数：62被引量：326H指数：9
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相关领域：医药卫生更多>>
相关作者：张洁费晓方池岛乔王本祥高晓霞更多>>
相关机构：长春中医学院横滨市立大学第四军医大学复旦大学更多>>
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Immunotherapy for atherosclerosis by targeting proinflammatory T cells
《Cell Research》2024年第7期467-468,共2页Amir Khan Klaus Ley 
Recent advancements in atherosclerosis management have shifted focus beyond lipid-lowering strategies towards addressing residual inflammatory risks associated with major adverse cardiovascular events.In a recent Cell...
关键词：ATHEROSCLEROSIS INFLAMMATION INFLAMMATORY 
Nonlinear proinflammatory effect of short-term PM_(2.5)exposure:A potential role of lipopolysaccharide
《Journal of Environmental Sciences》2024年第2期292-300,共9页Fangxia Shen Mutong Niu Haoxuan Chen Ting Zhang Jing Li Haijie Tong Yan Wu 
supported by the National Natural Science Foundation of China (Nos.42075117 and 41807306)。
The association between PM_(2.5)(particulate matter≤2.5μm)short-term exposure and its health effect is non-linear from the epidemiological studies.And this nonlinearity is suggested to be related with the PM_(2.5)he...
关键词：Fine PM PM_(2.5)pro-inflammatory effects Aerosol health effect ENDOTOXIN Oxidative stress 
Pseudomonas aeruginosa-induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species(ROS)-dependent way
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第11期1027-1036,共10页Haitao YANG Yan WANG Hui FAN Feixue LIU Huimiao FENG Xueqing LI Mingyi CHU Enzhuang PAN Daoyang TENG Huizhen CHEN Jingquan DONG 
supported by the Basic Science (Natural Science)Research Project of Higher Education of Jiangsu Province (No.21KJB230001);the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening (No.HY202101);the Lianyungang City Science and Technology Bureau Science and Technology Plan (Social Development)Project (No.SF2140);the 2022 Medical Research guiding Project of Jiangsu Provincial Health Commission (No.Z2022070);the 2023 Jiangsu Graduate Research Innovation Plan Project (No.SJCX23_1838);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative,exclusively aerobic,conditionally pathogenic bacterium with the characteristics of easy colonization,mutation,and multidrug resista...
关键词：belongs REACTIVE resistance 
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms被引量：3
《Signal Transduction and Targeted Therapy》2023年第8期3862-3876,共15页Na Jia Yunzhen Gao Min Li Yi Liang Yuwen Li Yunzhu Lin Shiqi Huang Qing Lin Xun Sun Qin He Yuqin Yao Ben Zhang Zhirong Zhang Ling Zhang 
This work was supported by the National Science Fund for Excellent Young Scholars(No:82022070);the Regional Innovation and Development Joint Fund(No:U20A20411).
Rheumatoid arthritis(RA)is a common chronic inflammatory disorder that usually affects joints.It was found that roburic acid(RBA),an ingredient from anti-RA herb Gentiana macrophylla Pall.,displayed strong anti-inflam...
关键词：inflammatory metabolism programming 
Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis
《Asian Pacific Journal of Tropical Biomedicine》2023年第8期348-358,共11页Sayed H.Seif el-Din Olfat A.Hammam Shahira M.Ezzat Samira Saleh Marwa M.Safar Walaa H.El-Maadawy Naglaa M.El-Lakkany 
funded by Theodore Bilharz Research Institute (grant number:ID-MS-99/A,Principal investigator:Naglaa M.El-Lakkany).
Objective:To evaluate the effect of hydroxysafflor yellow A(HSYA)on thioacetamide-induced liver fibrosis.Methods:Thioacetamide was administered to rats intraperitoneally in doses of 200 mg/kg twice a week for 12 weeks...
关键词：Hydroxysafflor yellow A THIOACETAMIDE Hepatic stellate cells Inflammatory markers Liver fibrosis p21 α-SMA APOPTOSIS 
Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug- Resistant Bacterial Sepsis
《Research》2023年第2期187-201,共15页Xuancheng Du Mingzhen Zhang Huiting Zhou Weijie Wang Chengmei Zhang Lei Zhang Yuanyuan Qu Weifeng Li Xiangdong Liu Mingwen Zhao Kangsheng Tu Yong-Qiang Li 
This work was supported by the National Natural Science Foundation of China(31500802,82172132,and 82000523);the Natural Science Foundation of Jiangsu Province(BK20190097 and BK20190053);the Program of Qilu Young Scholars of Shandong University;This work was also supported by the Cyrus Tang Foundation,the Taishan Scholars Program for Young Expert of Shandong Province(tsqn201909021);the Youth Cross-Scientific Innovation Group of Shandong University.
Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection.Effective treatment of bacterial sepsis remains a paramount clinical challenge,due to its astonishingl...
关键词：SEPSIS clinical PREVALENCE 
Spliceosomal GTPase Eftud2 regulates microglial activation and polarization被引量：3
《Neural Regeneration Research》2023年第4期856-862,共7页Guo-Chao Yang Yuan Shi Chao-Nan Fan Ying Li Meng-Qi Yuan Jie Pei Yan Wu Hai-Tao Wu 
supported by the National Natural Science Foundation of China,Nos.32171148,31770929,31522029(all to HTW);the National Key Research and Development Program of China,Nos.2021ZD0202500,2021YFA1101801(both to HTW);a grant from Beijing Commission of Science and Technology of China,Nos.Z181100001518001,Z161100000216154(both to HTW)。
Elongation factor Tu GTP binding domain protein 2(Eftud2)is a spliceosomal GTPase that serves as an innate immune modulator restricting virus infection.Microglia are the resident innate immune cells and the key player...
关键词：Alzheimer’s disease anti-inflammatory phenotype BV2 Eftud2 inflammation LIPOPOLYSACCHARIDE MICROGLIA nuclear factor-kappaB proinflammatory phenotype spliceosomal GTPase 
Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit被引量：5
《Cellular & Molecular Immunology》2023年第2期119-130,共12页Peng Xiao Ziwei Hu Jiaheng Lang Tianyuan Pan Randall Tyler Mertens Huilun Zhang Ke Guo Manlu Shen Hongqiang Cheng Xue Zhang Qian Cao Yuehai Ke 
supported by the National Natural Science Foundation of China(82271862 and 81873418 to YK,82171730 to PX,81970484 to QC);the Zhejiang Provincial Ten Thousand Program for Leading Talents of Science and Technology Innovation(2021R52015 to YK);the Natural Science Foundation of Zhejiang Province(LY20H160032 to PX,LQ21H090064 to TP).
Mannose is a naturally occurring sugar widely consumed in the daily diet;however,mechanistic insights into how mannose metabolism affects intestinal inflammation remain lacking.Herein,we reported that mannose suppleme...
关键词：COLITIS MANNOSE MACROPHAGES Intestinal epithelial cells TNF-ALPHA Endoplasmic reticulum stress 
Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis被引量：8
《Acta Pharmaceutica Sinica B》2022年第9期3618-3638,共21页Feixia Wang Zhanghao Li Li Chen Ting Yang Baoyu Liang Zili Zhang Jiangjuan Shao Xuefen Xu Guoping Yin Shijun Wang Hai Ding Feng Zhang Shizhong Zheng 
financially supported by the National Natural Science Foundation of China (81870423, 82173874 and 82073914);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions (19KJA310005, China);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine (2020YLXK022 and 2020YLXK023, China);the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica (JKLPSE202005, China);the Qing Lan Project of Jiangsu Higher Institutions (Young and Middle-Aged Academic Leader, China);the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX20_1493, China)
Senescence of activated hepatic stellate cells(aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression.Senescent cells often accompanied by a multi-faceted senescence-associated secretory phen...
关键词：Hepatic stellate cells SENESCENCE SASP ASCT2 Precursor IL-1α NF-ΚB Atractylenolide III Liver fibrosis 
Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo被引量：2
《Bioactive Materials》2022年第2期420-434,共15页Sarah Al-Maawi Sandra Rother Norbert Halfter Karen M.Fiebig Juliane Moritz Stephanie Moeller Matthias Schnabelrauch Charles James Kirkpatrick Robert Sader Hans-Peter Wiesmann Dieter Scharnweber Vera Hintze Shahram Ghanaati 
financial support from the DFG(Projektnummer 59307082-TRR67,subprojects A3,Z3);financially supported by the DFG(research fellowship,project number 420160411).
Sulfated glycosaminoglycans(sGAG)show interaction with biological mediator proteins.Although collagen-based biomaterials are widely used in clinics,their combination with high-sulfated hyaluronan(sHA3)is unexplored.Th...
关键词：Sulfated hyaluronan Collagen Wound healing Cellular reaction Multinucleated giant cells 
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